Trials / Unknown
UnknownNCT06273280
Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction.
Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction: a Prospective, Multicentre, International Randomized Study
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 345 (estimated)
- Sponsor
- Ziekenhuis Oost-Limburg · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this clinical trial is to evaluate guideline-directed medical therapy (GDMT) up-titration in patients with heart failure with reduced ejection fraction.The main question it aims to answer is the improvement in prescription rate and dose uptitration of quadruple GDMT in patients with HFrEF, assessed by a weighed composite score. Participants will be randomized towards control (standard of care, SOC) or intervention group. Researchers will compare SOC with protocol-based up-titration to see if the protocolized optimization improves prescription rate of GDMT.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | SOC | Physician-guided GDMT up-titration |
| PROCEDURE | Protocolized up-titration | Renal-based protocolized GDMT up-titration |
Timeline
- Start date
- 2024-02-14
- Primary completion
- 2025-12-01
- Completion
- 2026-03-01
- First posted
- 2024-02-22
- Last updated
- 2024-02-28
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT06273280. Inclusion in this directory is not an endorsement.