Trials / Completed
CompletedNCT03228030
Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 24 (actual)
- Sponsor
- Hamilton Health Sciences Corporation · Academic / Other
- Sex
- All
- Age
- 60 Years
- Healthy volunteers
- Not accepted
Summary
Heart failure (HF) is a major cardiovascular disease with increasing prevalence. Thiamine deficiency is common in HF patients. Previous small studies have shown that thiamine supplementation can improve left ventricular systolic function in HF, but larger clinical studies are lacking. Given the ease of supplementation and the potential benefits in HF, we aim to conduct a pilot randomized controlled trial (RCT) using high dose thiamine supplementation in HF patients. The main goal of this pilot study is to determine the feasibility of recruitment for an RCT of thiamine supplementation.
Conditions
- Heart Failure
- Heart Failure With Reduced Ejection Fraction
- Thiamine Deficiency
- Congestive Heart Failure
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | Thiamine | Capsules |
| DIETARY_SUPPLEMENT | Placebo | Identical capsules |
Timeline
- Start date
- 2018-04-02
- Primary completion
- 2021-04-30
- Completion
- 2021-04-30
- First posted
- 2017-07-24
- Last updated
- 2021-08-31
Locations
1 site across 1 country: Canada
Source: ClinicalTrials.gov record NCT03228030. Inclusion in this directory is not an endorsement.