Trials / Unknown
UnknownNCT03235700
Hyperemic Efficacy of IV Adenosine in HFrEF
Hyperemic Efficacy of Intravenous Infusion of Adenosine in Heart Failure With Reduced Ejection Fraction
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 125 (estimated)
- Sponsor
- Sejong General Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Little is known about the hyperemic efficacy of IV adenosine as well as safety in patients with heart failure with reduced ejection fraction (HFrEF) because they were excluded from the major FFR studies. We will evaluate the feasibility and hyperemic efficacy of IV adenosine in patients with HFrEF in comparison with IC nicorandil for invasive physiological assessment using a coronary pressure wire.
Detailed description
Little is known about the hyperemic efficacy of IV adenosine as well as safety in patients with heart failure with reduced ejection fraction (HFrEF) because they were excluded from the major FFR studies. We will evaluate the feasibility and hyperemic efficacy of IV adenosine in patients with HFrEF in comparison with IC nicorandil for invasive physiological assessment using a coronary pressure wire. Patients with an angiographically intermediate lesion (40-70% diameter stenosis) in a major epicardial coronary artery and with left ventricle ejection fraction ≤40% will be prospectively enrolled. FFR under the various hyperemic stimulation using IV adenosine 140 \& 180, IC adenosine, and IC nicorandil will be measured sequentially.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Maximal hyperemia with adenosine followed by nicorandil | IV adenosine 140 - IV adenosine 180 - IC adenosine (LCA 200/RCA 100) - IC nicorandil 2 |
| OTHER | Maximal hyperemia with nicorandil followed by adenosine | IC nicorandil 2 - IV adenosine 140 - IV adenosine 180 - IC adenosine (LCA 200/RCA 100) |
Timeline
- Start date
- 2017-03-01
- Primary completion
- 2020-02-28
- Completion
- 2020-02-28
- First posted
- 2017-08-01
- Last updated
- 2017-08-01
Locations
1 site across 1 country: South Korea
Source: ClinicalTrials.gov record NCT03235700. Inclusion in this directory is not an endorsement.