Trials / Unknown
UnknownNCT06316661
CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF
MAgnetic Resonance Non-contrast Assessment of Cardiac Microvascular Dysfunction in Patients With Heart Failure With PrEserveD Ejection Fraction (MAPPED)
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (estimated)
- Sponsor
- Istituto Auxologico Italiano · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Heart failure with preserved ejection fraction (HFpEF) causes hospitalizations, premature mortality and high health care costs. This is also due to poor understanding of HFpEF pathogenesis and, thus, lack of specific therapies. Prompted by the recent demonstration that HFpEF clusters different clinical phenotypes, the investigators propose that these phenogroups are driven by distinct myocardial abnormalities. Cardiac Magnetic Resonance (CMR) can help filling this gap in knowledge: on top of providing gold standard measurements for myocardial volume and cellular mass, recent technical advantages mean that this test can assess and quantify left ventricular extracellular volume, fibrosis and microvascular function accurately and non-invasively. In HFpEF patients, the investigators aim at assessing 1) the coronary microvascular function impairment; 2) the myocardial fibrotic burden; - seeking to understand the disease in order to improve care and cardiovascular outcomes for these patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | stress perfusion cardiac magnetic resonance | stress perfusion cardiac magnetic resonance according to guidelines, with quantitative evaluation for microvascular dysfunction assessment |
| DIAGNOSTIC_TEST | cardiopulmonary exercise test | bike exercise with ECG and non invasive respiratory gas exchange monitoring |
Timeline
- Start date
- 2019-03-01
- Primary completion
- 2024-12-30
- Completion
- 2024-12-30
- First posted
- 2024-03-18
- Last updated
- 2024-03-18
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06316661. Inclusion in this directory is not an endorsement.