| Recruiting | AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF) | Phase 2 | 2025-02-06 |
| Recruiting | Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fract Heart Failure, Heart Failure With Reduced Ejection Fraction | Phase 3 | 2024-12-19 |
| Recruiting | A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Ca Pediatric, Symptomatic Obstructive Hypertrophic Cardiomyopathy | Phase 2 / Phase 3 | 2024-05-29 |
| Active Not Recruiting | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy | Phase 3 | 2023-08-30 |
| Completed | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Obstructive Hypertrophic Cardiomyopathy (oHCM) | Phase 3 | 2023-06-20 |
| Completed | Study to Evaluate the Effect of Aficamten Administration on QT/QTc Interval Healthy Participants | Phase 1 | 2023-05-15 |
| Completed | A Single and Multiple Ascending Dose Study of CK-4021586 in Healthy Adult Participants Healthy Participants | Phase 1 | 2023-05-09 |
| Terminated | A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants Healthy Participants | Phase 1 | 2022-12-06 |
| Terminated | A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) Amyotrophic Lateral Sclerosis | Phase 3 | 2022-08-04 |
| Completed | Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM) | Phase 3 | 2022-02-01 |
| Terminated | A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS Amyotrophic Lateral Sclerosis | Phase 3 | 2021-08-16 |
| Enrolling By Invitation | Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM Symptomatic Hypertrophic Cardiomyopathy (HCM) | Phase 2 / Phase 3 | 2021-05-06 |
| Withdrawn | Omecamtiv Mecarbil Post-trial Access Study Chronic Heart Failure With Reduced Ejection Fraction | Phase 3 | 2020-12-18 |
| Completed | Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CK-3773274 Hypertrophic Cardiomyopathy (HCM) | Phase 2 | 2020-01-10 |
| Completed | Study to Assess the Effect of Omecamtiv Mecarbil (OM) on QT/QTc Intervals in Healthy Adults QT Intervals Changes, QTc Intervals Changes | Phase 1 | 2019-11-14 |
| Completed | Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure Heart Failure With Reduced Ejection Fraction | Phase 3 | 2019-04-09 |
| Completed | A Single and Multiple Ascending Dose Study of CK-3773274 in Healthy Adult Subjects Symptomatic Obstructive Hypertrophic Cardiomyopathy, Healthy Subjects | Phase 1 | 2018-12-04 |
| Completed | A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Scler Amyotrophic Lateral Sclerosis | Phase 2 | 2017-07-24 |
| Completed | Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fr Heart Failure | Phase 3 | 2017-01-06 |
| Completed | A Study for Patients Who Completed VITALITY-ALS (CY 4031) Amyotrophic Lateral Sclerosis (ALS) | Phase 3 | 2016-10-17 |
| Completed | Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection F Heart Failure With Reduced Ejection Fraction | Phase 2 | 2016-04-14 |
| Completed | A Study of CK-2127107 in Patients With Spinal Muscular Atrophy Spinal Muscular Atrophy | Phase 2 | 2016-01-14 |
| Completed | Pharmacokinetics and Safety Study of Omecamtiv Mecarbil in Healthy Japanese Adults Healthy Volunteer | Phase 1 | 2015-11-13 |
| Completed | Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year Amyotrophic Lateral Sclerosis | Phase 3 | 2015-09-03 |
| Completed | COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure Modified Release Oral Formulation, Left Ventricular Systolic Dysfunction, Chronic Heart Failure | Phase 2 | 2013-02-26 |
| Completed | Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency Heart Failure | Phase 1 | 2012-11-01 |
| Completed | Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis | Phase 2 | 2012-10-01 |
| Completed | Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis ( Amyotrophic Lateral Sclerosis | Phase 2 | 2011-11-01 |
| Completed | A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis | Phase 2 | 2011-06-01 |
| Completed | Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Le Heart Failure | Phase 2 | 2011-04-01 |
| Terminated | Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis Myasthenia Gravis | Phase 2 | 2010-12-01 |
| Withdrawn | Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure Patients Heart Failure | Phase 2 | 2010-07-01 |
| Completed | A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication Intermittent Claudication, Peripheral Artery Disease | Phase 2 | 2010-05-01 |
| Completed | A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis | Phase 2 | 2010-03-01 |
| Completed | Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart Failure Heart Failure | Phase 2 | 2009-04-01 |
| Terminated | Phase II Study of the Effect of CK-1827452 Injection on Myocardial Efficiency Heart Failure | Phase 2 | 2008-09-01 |
| Completed | PK and Tolerability of IV and Oral CK-1827452 in Patients With Ischemic Cardiomyopathy and Angina Heart Failure, Myocardial Ischemia, Angina Pectoris | Phase 2 | 2008-04-01 |
| Terminated | A Study of Ispinesib in Metastatic Breast Cancer Breast Neoplasms | Phase 1 | 2007-12-01 |
| Completed | A Study of CK-1827452 Infusion in Stable Heart Failure Heart Failure | Phase 2 | 2007-04-01 |
| Completed | A Study of SB-743921 in Non-Hodgkin Lymphoma and Hodgkin Lymphoma Non-Hodgkin's Lymphoma, Hodgkin's Disease | Phase 1 / Phase 2 | 2006-04-01 |
| Completed | A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers Heart Failure | Phase 1 | 2005-08-01 |