NCT05715697

Renal Denervation in Patients With Chronic Heart Failure With Preserved Ejection Fraction

The First Affiliated Hospital of Xinjiang Medical University

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Xinjiang Medical University · Academic / Other
• Sex: All
• Age: 21 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aims to explore the potential of RDN as a therapy for HFpEF in a Prospective, Multicenter, Randomized, Blinded, Sham-controlled Study.

Detailed description

Heart failure is one of the most important diseases worldwide, with a 5-year mortality of up to 75% in symptomatic patients. While substantial progress has been made in the treatment of patients with reduced left ventricular ejection fraction (HFrEF), mortality for patients with heart failure and preserved ejection fraction (HFpEF) remains unchanged, despite a comparable prevalence and mortality of the disease as for heart failure with reduced ejection fraction. Heart failure with preserved ejection fraction has a high mortality, which is contrasted by a total absence of therapy options besides symptomatic diuretic treatment. This study aims to explore the potential of RDN as a therapy for HFpEF in a Prospective, Multicenter, Randomized, Blinded, Sham-controlled Study.

Conditions

• Heart Failure With Preserved Ejection Fraction
• Renal Denervation

Interventions

Type	Name	Description
PROCEDURE	Sham procedure and maintenance of heart failure medications	Sham intervention, maintenance of heart failure medications
PROCEDURE	Renal denervation and maintenance of heart failure medications	Renal denervation and maintenance of heart failure medications

Timeline

• Start date: 2023-09-01
• Primary completion: 2024-09-01
• Completion: 2026-09-01
• First posted: 2023-02-08
• Last updated: 2024-02-01

Locations

1 site across 1 country: China