NCT04063579

Cardiac Magnetic Resonance Assessment for Heart Failure With Preserved Ejection Fraction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 172 (actual)
• Sponsor: The University of Hong Kong · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This is a prospective study that aims to define the utility of cardiac magnetic resonance feature tracking (CMR-FT) as a non-invasive quantification tool to assess diastolic functionality in patients with Heart Failure with preserved ejection fraction.

Detailed description

Despite the increasing prevalence and poor prognosis of HFpEF worldwide, it is facing diagnostic challenges due to its non-specific clinical manifestations. Currently, echocardiography serves as the main diagnostic tool, but alternatives are limited to less preferred invasive procedures in most clinical situations. It is therefore proposed to investigate HFpEF using cardiovascular magnetic resonance imaging (CMR), as an alternative non-invasive diagnostic tool which carries lower risk than invasive procedures. The study aims to: (1) access the utility of CMR-FT as a new indicator to diagnose diastolic dysfunction by differentiating HFpEF patients from non-HFpEF patient and normal volunteers. (2) Compare accuracy of CMR-FT to CMR tagging and phase contrast imaging.

Conditions

• Heart Failure With Preserved Ejection Fraction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP), cardiac catheterization	Imaging, blood tests, LV pressure measurement
DIAGNOSTIC_TEST	Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP)	Imaging and Blood tests

Timeline

• Start date: 2018-06-01
• Primary completion: 2021-09-29
• Completion: 2021-12-31
• First posted: 2019-08-21
• Last updated: 2023-05-10

Locations

1 site across 1 country: Hong Kong