| Withdrawn | Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis NCT02988297 | Revalesio Corporation | Phase 2 |
| Not Yet Recruiting | iBCI Optimization for Veterans With Paralysis NCT05470478 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis NCT07224269 | University of Iowa | EARLY_Phase 1 |
| Not Yet Recruiting | A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patients NCT06513546 | PLL TX AUSTRALIA PTY LTD | Phase 1 / Phase 2 |
| Not Yet Recruiting | Digital Speech Markers for Monitoring ALS in Spanish Speakers NCT07341334 | Nova Southeastern University | — |
| Not Yet Recruiting | Research of Traditional Chinese Medicine Oral Preparation of C. Cicadae in the Treatment of ALS Patients With NCT07467746 | The Third Xiangya Hospital of Central South University | Phase 2 |
| Recruiting | Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI) NCT07357428 | Paradromics | N/A |
| Recruiting | Diagnostic Accuracy of SleepImage Technology for Detecting Respiratory Failure in Patients With Amyotrophic La NCT07502677 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Recruiting | Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease NCT07478172 | University of Missouri-Columbia | N/A |
| Not Yet Recruiting | Personalized Antisense Oligonucleotide Therapy for A Single Patient With CHCHD10 ALS (nL18576) NCT07423494 | n-Lorem Foundation | Phase 1 / Phase 2 |
| Not Yet Recruiting | Efficacy and Safety of Tazbentetol in ALS Participants NCT07325591 | Spinogenix | Phase 2 / Phase 3 |
| Not Yet Recruiting | Metagenomic Characterization of the Intestinal Microbiota in ALS Patients and Association With Clinical Phenot NCT06771414 | Assistance Publique - Hôpitaux de Paris | — |
| Active Not Recruiting | Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS) NCT07204977 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 |
| Recruiting | Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS NCT07322003 | Prilenia | Phase 3 |
| Recruiting | A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Pa NCT07290062 | Insmed Gene Therapy LLC | Phase 1 |
| Recruiting | A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismuta NCT07259980 | Biogen | — |
| Recruiting | Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS NCT07287397 | Vector Y Therapeutics | Phase 1 / Phase 2 |
| Recruiting | A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS) NCT07341984 | Charlotte Vogt | N/A |
| Recruiting | A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyo NCT07223723 | Biogen | Phase 4 |
| Suspended | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for ALS NCT05003921 | The Foundation for Orthopaedics and Regenerative Medicine | Phase 1 |
| Not Yet Recruiting | Tideglusib for the Treatment of Amyotrophic Lateral Sclerosis NCT05105958 | University of Zurich | Phase 2 |
| Recruiting | Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Latera NCT07414212 | Biogipuzkoa Health Research Institute | Phase 1 / Phase 2 |
| Recruiting | Assessing Perceptual Effects of Interactive Tasks NCT06828523 | Penn State University | N/A |
| Recruiting | VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communicatio NCT07224256 | Neuralink Corp | N/A |
| Recruiting | Needs of ALS Patients With C9orf72 Mutation and Their Caregivers NCT07302321 | Istituto Auxologico Italiano | — |
| Not Yet Recruiting | Polish Version Dyspnea in Amyotrophic Lateral Sclerosis NCT07178574 | Jakub Antczak | — |
| Recruiting | Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Amisodin in Healthy Adult Subjects With Amyotr NCT07221240 | PRG Science & Technology Co., Ltd. | Phase 1 |
| Recruiting | Identifying Biomarkers in ALS Patients Using Neuronal Derived Extracellular Vesicles NCT07334743 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Enrolling By Invitation | Electrophysiology and Ultrasound of Respiratory Muscles and Respective Nerves to Predict Respiratory Insuffici NCT06841341 | Jagiellonian University | — |
| Unknown | Validation of the "ExSpiron©" in Patients With ALS NCT04089696 | University Medical Center Groningen | N/A |
| Recruiting | Modeling Amyotrophic Lateral Sclerosis With Fibroblasts NCT06450691 | Assistance Publique - Hôpitaux de Paris | N/A |
| Not Yet Recruiting | Safety of Intrathecal Riluzole in Patients With Amyotrophic Lateral Sclerosis NCT07093268 | Brain Trust Bio | Phase 1 |
| Terminated | A Study of STRO4 in Patients Amyotrophic Lateral Sclerosis (ALS) NCT06910384 | New England Cell Therapeutics, Inc. | Phase 2 |
| Recruiting | Video-Based Proprioceptive Exercise Program in ALS NCT07292545 | Tarsus University | N/A |
| Recruiting | Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth NCT07491484 | TidalHealth, Inc. | — |
| Not Yet Recruiting | MRG-001 in Patients With Amyotrophic Lateral Sclerosis NCT06315608 | MedRegen LLC | Phase 2 |
| Not Yet Recruiting | Evaluation of the Early Use of the Pressure Relaxer in the Respiratory Impairment of Patients With Amyotrophic NCT05297487 | Centre Hospitalier Universitaire de la Réunion | N/A |
| Not Yet Recruiting | hUC-MSC-sEV-001 Nasal Drops for Neurodegenerative Diseases NCT06607900 | Xuanwu Hospital, Beijing | Phase 1 |
| Not Yet Recruiting | Efficacy and Safety of MSC-NTF (NurOwn) in Participants With Early Symptomatic ALS and Moderate Disease Presen NCT06973629 | Brainstorm-Cell Therapeutics | Phase 3 |
| Recruiting | A Study of Ranolazine in ALS NCT06527222 | Swathy Chandrashekhar, MBBS | Phase 2 |
| Recruiting | High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project NCT06881979 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Recruiting | LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS NCT07312240 | Istituto Auxologico Italiano | N/A |
| Recruiting | Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS) NCT07193953 | Sunnybrook Health Sciences Centre | Phase 1 |
| Recruiting | Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis NCT06656702 | Johns Hopkins University | EARLY_Phase 1 |
| Recruiting | Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS NCT06126315 | Mario Negri Institute for Pharmacological Research | Phase 2 / Phase 3 |
| Recruiting | EIM Via the Myolex mScan as an ALS Biomarker NCT06491732 | Beth Israel Deaconess Medical Center | — |
| Recruiting | Research on Wireless Brain Implant System for General Control of External Devices NCT06829212 | Shanghai StairMed Technology Co., Ltd. | N/A |
| Enrolling By Invitation | An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative D NCT06875739 | Fondazione Don Carlo Gnocchi Onlus | — |
| Recruiting | Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation NCT06551649 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula I NCT06609213 | Andrea Charvet | N/A |
| Recruiting | RAPA-501 Therapy for ALS NCT04220190 | Rapa Therapeutics LLC | Phase 2 / Phase 3 |
| Recruiting | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects Wit NCT06556394 | Ractigen Therapeutics. | Phase 1 |
| Recruiting | TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis NCT06726577 | Talengen Institute of Life Sciences, Shenzhen, P.R. China. | Phase 1 / Phase 2 |
| Recruiting | Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALS NCT06598202 | Xuanwu Hospital, Beijing | Phase 1 / Phase 2 |
| Not Yet Recruiting | Tofacitinib in Patients With Amyotrophic Lateral Sclerosis NCT06689982 | Beijing Tiantan Hospital | EARLY_Phase 1 |
| Completed | Personalized Antisense Oligonucleotide Therapy for A Single Participant With TARDBP ALS NCT07095712 | n-Lorem Foundation | Phase 1 / Phase 2 |
| Recruiting | Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - NCT06820008 | University of Dublin, Trinity College | — |
| Terminated | RolloverTreatment With Triumeq for People With ALS Following the Lighthouse II Trial NCT06658977 | Macquarie University, Australia | Phase 3 |
| Completed | A Study Exploring the PK/PD Relationship of QRL-101 in Adults With ALS NCT06714396 | QurAlis Corporation | Phase 1 |
| Recruiting | A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS NCT06249867 | Oliver Blanchard | Phase 2 |
| Recruiting | Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications NCT06266403 | Penn State University | N/A |
| Recruiting | Polish Version Fatigue Severity Scale NCT06668649 | Jakub Antczak | — |
| Unknown | EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis NCT06169696 | Synaptrix Labs Inc. | N/A |
| Active Not Recruiting | ALS Phase II Study of NX210c NCT06365216 | Axoltis Pharma | Phase 2 |
| Active Not Recruiting | A Safety and Efficacy Study of ARGX-119 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) NCT06441682 | argenx | Phase 2 |
| Enrolling By Invitation | Personalized Antisense Oligonucleotide for Participants With CHCHD10 ALS NCT07095686 | n-Lorem Foundation | Phase 1 / Phase 2 |
| Recruiting | French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis NCT06147843 | University Hospital, Limoges | N/A |
| Recruiting | Multicenter ALS Imaging Study NCT06735014 | University of Minnesota | — |
| Active Not Recruiting | Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study NCT06119087 | University of Pennsylvania | N/A |
| Recruiting | Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746 | Casa di Cura San Raffaele Cassino | — |
| Enrolling By Invitation | Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disor NCT06605612 | LMU Klinikum | — |
| Not Yet Recruiting | Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis NCT06541873 | IRCCS San Raffaele | — |
| Not Yet Recruiting | Effect of Salbutamol on Walking Capacity in Ambulatory ALS Patients NCT05860244 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Active Not Recruiting | Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adu NCT06100276 | UniQure Biopharma B.V. | Phase 1 / Phase 2 |
| Recruiting | PREVENT ALL ALS Study NCT06581861 | St. Joseph's Hospital and Medical Center, Phoenix | — |
| Recruiting | ASSESS ALL ALS Study NCT06578195 | St. Joseph's Hospital and Medical Center, Phoenix | — |
| Recruiting | Digital Assessment of Speech and Fine Motor Control in ALS NCT06315673 | Milton S. Hershey Medical Center | — |
| Not Yet Recruiting | Clinical Trial - Analyzing Participation Experiences Of Amyotrophic Lateral Sclerosis Patients NCT05423678 | Power Life Sciences Inc. | — |
| Active Not Recruiting | Personalized Antisense Oligonucleotide for a Single Participant With CHCHD10 ALS NCT06977451 | n-Lorem Foundation | Phase 1 / Phase 2 |
| Recruiting | FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases NCT06539169 | xCures | — |
| Recruiting | Ultra-high-caloric, Fatty Diet in ALS NCT06280079 | University of Ulm | N/A |
| Unknown | Use of 1 Minute Sit to Stand Test for Physical Capacity and Effort Related Desaturation in Amyotrophic Lateral NCT05151211 | Istanbul University - Cerrahpasa | — |
| Recruiting | Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect NCT06396260 | Aalborg University Hospital | N/A |
| Recruiting | Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long NCT06426030 | Masaryk University | — |
| Recruiting | Reinnervation and Neuromuscular Transmission in ALS NCT06219759 | University of Aarhus | — |
| Recruiting | Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2 NCT05983211 | Sunnybrook Health Sciences Centre | N/A |
| Not Yet Recruiting | Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment o NCT06391645 | Beijing Tiantan Hospital | Phase 2 / Phase 3 |
| Active Not Recruiting | Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS NCT06392126 | n-Lorem Foundation | Phase 1 / Phase 2 |
| Active Not Recruiting | Safety and Efficacy of Intravenous Administration of SHED-CM for ALS NCT06889857 | Hitonowa Medical | EARLY_Phase 1 |
| Recruiting | Alleviating Persistent Dyspnea in Amyotrophic Lateral Sclerosis Patients Treated With Non-Invasive Ventilation NCT06021938 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Spinal Cord Associative Plasticity for ALS NCT06172621 | VA Office of Research and Development | N/A |
| Unknown | Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cel NCT02478450 | Q Therapeutics, Inc. | Phase 1 / Phase 2 |
| Completed | Contralateral R1 in Amyotrophic Lateral Sclerosis NCT06206629 | Hospices Civils de Lyon | — |
| Unknown | DIAGALS: Relation Between Tar DNA Binding Protein(TDP)-43 et Nrf-2 in ALS: a Track to Improve Diagnosis and Pr NCT06230562 | University Hospital, Tours | N/A |
| Recruiting | Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS) NCT06344260 | Casa Sollievo della Sofferenza IRCCS | Phase 2 |
| Terminated | A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS) NCT06215755 | Verge Genomics | Phase 1 |
| Recruiting | Precise Robotically IMplanted Brain-Computer InterfacE NCT06429735 | Neuralink Corp | N/A |
| Withdrawn | Study of AROSOD-1 in Adult Participants With Amyotrophic Lateral Sclerosis (ALS) NCT05949294 | Arrowhead Pharmaceuticals | Phase 1 |
| Recruiting | potentiALS - Quality of Life Among Patients With Amyotrophic Lateral Sclerosis NCT06441448 | University of Leipzig | — |
| Withdrawn | Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS NCT05830214 | University of Alberta | — |
| Completed | Retrospective Study on the Safety and Therapeutic/Improvement Effects of Intravenous Administration of SHED-CM NCT06608719 | Hitonowa Medical | — |
| Recruiting | Proteinopathies Expression in Skin of Neurodegenerative Disorders NCT06528964 | Universidad Autonoma de San Luis Potosí | — |
| Unknown | Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral Sclerosis NCT06181526 | Beijing Tiantan Hospital | Phase 1 |
| Recruiting | Emotion Processing Among Patients With ALS NCT06566651 | University of Aarhus | — |
| Active Not Recruiting | Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral Scleros NCT05974579 | Université de Sherbrooke | Phase 1 |
| Recruiting | Development of Targeted RNA-Seq for Amyotrophic Lateral Sclerosis Diagnosis NCT06083584 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZYIL1 in Patients With Amyotrophic L NCT05981040 | Zydus Lifesciences Limited | Phase 2 |
| Completed | Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis NCT05979688 | University of Alabama at Birmingham | N/A |
| Recruiting | Advances in Telephone-based Cognitive Screening Procedures NCT06337578 | Istituto Auxologico Italiano | — |
| Recruiting | Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia NCT05724173 | Leigh R. Hochberg, MD, PhD. | N/A |
| Recruiting | Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02) NCT06094205 | Leigh R. Hochberg, MD, PhD. | N/A |
| Unknown | A Mindful Community for People With ALS and Their Primary Caregivers NCT05595850 | Harvard University | N/A |
| Active Not Recruiting | Ambulatory Versus Inpatient Initiation of Home Mechanical Ventilation NCT05829330 | Anne Kathrine Staehr-Rye | N/A |
| Active Not Recruiting | An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patie NCT06454682 | RJK Biopharma Ltd | EARLY_Phase 1 |
| Recruiting | Breathing with Amyotrophic Lateral Sclerosis NCT05819931 | University Hospital, Toulouse | N/A |
| Not Yet Recruiting | Investigation of Cannabinoid 2-receptor Expression in the Brain and Spine of ALS-patients Compared to Healthy NCT05880563 | Markus Weber | Phase 1 |
| Completed | Exploring Accessible Beauty for Individuals With Upper Extremity Deficits NCT05945784 | Casa Colina Hospital and Centers for Healthcare | — |
| Active Not Recruiting | ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach NCT05928416 | ZIWIG | — |
| Unknown | Amyotrophic Lateral Sclerosis Non-invasive Ventilation Exchange NCT05837507 | University Hospital, Montpellier | N/A |
| Completed | Study of SPG302 in Healthy Volunteers and ALS Participants NCT05882695 | Spinogenix | Phase 1 |
| Unknown | Neurobiological and Immunological Mechanisms of Dyspnea in ALS (BIOPNEA) NCT04332198 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Recruiting | Anticipated Patient and Caregiver Burden NCT05632757 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Early Feasibility Study of the MyoRegulator® for Treatment of ALS NCT06165172 | PathMaker Neurosystems Inc. | N/A |
| Unknown | Amyotrophic Lateral Sclerosis Registry NCT05892822 | yilong Wang | — |
| Unknown | A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS NCT05959850 | The Florey Institute of Neuroscience and Mental Health | Phase 2 |
| Completed | Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral Sclerosis NCT05889572 | MaaT Pharma | Phase 1 |
| Completed | HEALEY ALS Platform Trial - Regimen G DNL343 NCT05842941 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Recruiting | Contribution of Diaphragmatic Ultrasound for Monitoring Diaphragmatic Function in Patients With Amyotrophic La NCT05352958 | Centre Hospitalier Universitaire Dijon | — |
| Recruiting | Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP NCT05562960 | National Taiwan University Hospital | N/A |
| Recruiting | Holter of Movement in Patients With Amyotrophic Lateral Sclerosis. NCT06228001 | Centre Hospitalier Universitaire de Liege | — |
| Recruiting | Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families NCT05744310 | Haukeland University Hospital | N/A |
| Completed | Perception of Unpleasant Sensations During Study Procedures in ALS Patients NCT06325865 | Istituto Auxologico Italiano | — |
| Recruiting | Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis NCT06318598 | Istituto Auxologico Italiano | — |
| Recruiting | Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases NCT06318585 | Istituto Auxologico Italiano | — |
| Active Not Recruiting | Regulatory T Cells for Amyotrophic Lateral Sclerosis NCT05695521 | Cellenkos, Inc. | Phase 1 |
| Completed | HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262 NCT05740813 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Terminated | Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis NCT05866926 | Ferrer Internacional S.A. | Phase 3 |
| Active Not Recruiting | Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used NCT04380649 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Dysphagia, QoL and Attitudes Towards PEG in ALS Patients NCT05336760 | University Rehabilitation Institute, Republic of Slovenia | — |
| Completed | Extension Study Evaluating The Safety And Tolerability of AMX0035 NCT05619783 | Amylyx Pharmaceuticals Inc. | Phase 3 |
| Active Not Recruiting | A Study Evaluating the Safety and Tolerability of QRL-201 in ALS NCT05633459 | QurAlis Corporation | Phase 1 |
| Unknown | Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS) NCT05107349 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial NCT05189106 | Massachusetts General Hospital | Phase 1 / Phase 2 |
| Unknown | Staging System in Amyotrophic Lateral Sclerosis NCT04858555 | University Hospital, Limoges | — |
| Completed | Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol) NCT05508074 | InFlectis BioScience | Phase 2 |
| Unknown | The Effect of Low-İntensity Combined Exercises in Patients With Early Stage ALS. NCT05716074 | Istanbul University - Cerrahpasa | N/A |
| Recruiting | Dazucorilant in Patients With Amyotrophic Lateral Sclerosis NCT05407324 | Corcept Therapeutics | Phase 2 |
| Recruiting | NYSCF Scientific Discovery Biobank NCT06203106 | New York Stem Cell Foundation Research Institute | — |
| Completed | Evaluate the Safety of Neuronata-R® Inj. Suspended With HypoTHermosol® FRS (HTS-FRS) in Patients With ALS NCT06676423 | Corestemchemon, Inc. | Phase 1 |
| Unknown | Rehabilitation in SOD1 ALS Treated With Tofersen NCT05725759 | Washington University School of Medicine | — |
| Unknown | Remote Home Assessment of Patients With Amyotrophic Lateral Sclerosis NCT06046599 | King's College London | — |
| Completed | TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps NCT04998305 | Hiroshi Mitsumoto | Phase 1 / Phase 2 |
| Completed | Quality of Life Evaluation with the SRI Questionnaire of ALS Patient with Non-invasive Ventilation NCT05498883 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Study of AMDX-2011P as a Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidoge NCT05542576 | Amydis Inc. | Phase 1 / Phase 2 |
| Recruiting | Virtual Peer-to-peer Support Programme for Carers of MND NCT04695210 | King's College London | N/A |
| Terminated | A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) NCT05442775 | Cytokinetics | Phase 3 |
| Recruiting | Patients' and Caregivers' Views of Multidimensional Care in Amyotropic Lateral Sclerosis in Germany NCT06418646 | Technische Universität Dresden | — |
| Recruiting | Optimizing INITIation of Non-invasive Ventilation in ALS Patients NCT05033951 | University Medical Center Groningen | — |
| Completed | Longitudinal Evaluation of Short-Chain Fatty Acid Profiles During the Natural Disease Course and a Mediterrane NCT07178067 | George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures | — |
| Unknown | Stratification of Presymptomatic Amyotrophic Lateral Sclerosis: the Development of Novel Imaging Biomarkers NCT05358431 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit NCT04468919 | Oregon Health and Science University | N/A |
| Unknown | QCT in ALS Diagnosis, Mechanistic Understanding and Follow-up NCT06284161 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II) NCT05404867 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension NCT05357950 | NeuroSense Therapeutics Ltd. | Phase 2 |
| Completed | A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS NCT05407428 | NeuraLight | — |
| Terminated | Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS NCT05349721 | PTC Therapeutics | Phase 2 |
| Active Not Recruiting | CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS NCT05306457 | Cedars-Sinai Medical Center | Phase 1 |
| Active Not Recruiting | COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis NCT05035823 | Synchron Medical, Inc. | N/A |
| Withdrawn | SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis NCT05041114 | Synchron Medical, Inc. | N/A |
| Terminated | Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) NCT05237284 | Sanofi | Phase 2 |
| Recruiting | Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS) NCT04820478 | University of Ulm | N/A |
| Unknown | mGluR5 Imaging in ALS Using PET NCT05340660 | Nathalie Braun | N/A |
| Unknown | Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis NCT05328492 | University Hospitals Coventry and Warwickshire NHS Trust | N/A |
| Recruiting | A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunt NCT05279755 | ProJenX | Phase 1 |
| Terminated | Triumeq in Amyotrophic Lateral Sclerosis NCT05193994 | Macquarie University, Australia | Phase 3 |
| Completed | HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose NCT05136885 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Completed | A Study to Assess the Effect of Erythromycin on the Test Medicine (SAR443820) When Given Orally as Tablets to NCT05797753 | Sanofi | Phase 1 |
| Active Not Recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register S NCT06209515 | Kuopio University Hospital | — |
| Active Not Recruiting | Remote Speech and Swallowing Assessment in ALS NCT04889898 | Milton S. Hershey Medical Center | — |
| Completed | Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral S NCT05163886 | OrphAI Therapeutics | Phase 2 |
| Active Not Recruiting | Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL) NCT05218668 | Woolsey Pharmaceuticals | Phase 2 |
| Completed | Online Self-Compassion Course for pALS (Compassion pALS) NCT05202743 | Washington University School of Medicine | — |
| Recruiting | Investigation on the Cortical Communication (CortiCom) System NCT03567213 | Johns Hopkins University | N/A |
| Completed | 3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS) NCT05039268 | Macquarie University, Australia | Phase 2 |
| Completed | Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients NCT04654689 | Fundación Universidad Católica de Valencia San Vicente Mártir | Phase 2 |
| Completed | A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis NCT05176093 | Helixmith Co., Ltd. | Phase 2 |
| Active Not Recruiting | An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on S NCT05299658 | Clene Nanomedicine | Phase 2 |
| Active Not Recruiting | Study in ALS With Abatacept & IL-2 NCT06307301 | The Methodist Hospital Research Institute | Phase 1 |
| Active Not Recruiting | Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment NCT05021536 | Amylyx Pharmaceuticals Inc. | Phase 3 |
| Unknown | Open Label Extension of TUDCA-ALS Study NCT05753852 | Humanitas Mirasole SpA | Phase 3 |
| Completed | Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lat NCT05178810 | Ferrer Internacional S.A. | Phase 3 |
| Recruiting | A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension Study NCT05095571 | Haukeland University Hospital | N/A |
| Completed | A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD NCT04993755 | Transposon Therapeutics, Inc. | Phase 2 |
| Unknown | Telehealth Implementation of Brain-Computer Interface NCT05951556 | Shirley Ryan AbilityLab | N/A |
| Recruiting | Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments NCT04816227 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Terminated | A Phase 1 Study to Investigate the Safety and Pharmacokinetics of Fosigotifator in Patients With Amyotrophic L NCT04948645 | AbbVie | Phase 1 |
| Completed | Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis NCT04953286 | University Hospital, Tours | N/A |
| Recruiting | Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS NCT05204017 | University of Alberta | — |
| Terminated | A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS NCT05053035 | Alector Inc. | Phase 2 |
| Completed | A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in NCT05039099 | AL-S Pharma | Phase 2 |
| Terminated | Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALS NCT04749433 | Johns Hopkins University | Phase 1 |
| Terminated | A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS NCT04944784 | Cytokinetics | Phase 3 |
| Withdrawn | IC14 for Treatment of Amyotrophic Lateral Sclerosis NCT03508453 | Implicit Bioscience | Phase 2 |
| Completed | A Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL343 in Participants With Amyotro NCT05006352 | Denali Therapeutics Inc. | Phase 1 |
| Recruiting | Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS) NCT06008249 | Stichting TRICALS Foundation | Phase 3 |
| Unknown | Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis NCT04953494 | Peking University Third Hospital | — |
| Completed | Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) NCT04788745 | The University of Queensland | Phase 2 |
| Enrolling By Invitation | Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China NCT04961450 | Peking University Third Hospital | — |
| Completed | New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis NCT04691011 | Assistance Publique Hopitaux De Marseille | N/A |
| Active Not Recruiting | FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotroph NCT04768972 | Ionis Pharmaceuticals, Inc. | Phase 3 |
| Completed | Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorder NCT04939818 | Novoic Limited | — |
| Unknown | A Longitudinal Analysis of Biomarkers in Patients With ALS NCT05309408 | Holy Cross Hospital, Florida | — |
| Recruiting | Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures NCT05137665 | Target ALS Foundation, Inc. | — |
| Completed | Inspiratory Muscle Training With Powerbreath Device in Patients With ALS NCT04889248 | Universidad Francisco de Vitoria | N/A |
| Unknown | EMERALD TRIAL Open Label Extension Study NCT04997954 | Gold Coast Hospital and Health Service | Phase 4 |
| Recruiting | Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS NCT05747937 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Completed | Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS and Caregivers NCT04719403 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Frequency of SOD1 and C9orf72 Gene Mutations in French ALS NCT04819555 | University Hospital, Tours | — |
| Unknown | Telespirometry in Amyotrophic Lateral Sclerosis (ALS) NCT05106569 | State University of New York - Upstate Medical University | — |
| Completed | Patient's TeleMonitoring With Amyotrophic Lateral Sclerosis Treated by Non Invasive Ventilation at Home. NCT04797845 | University Hospital, Toulouse | N/A |
| Recruiting | Intermuscular Coherence as a Biomarker for ALS NCT05104710 | University of Chicago | — |
| Unknown | Counterfactual Thinking in Amyotrophic Lateral Sclerosis NCT05768646 | Istituto Auxologico Italiano | — |
| Completed | Enoxacin for Amyotrophic Lateral Sclerosis (ALS) NCT04840823 | McGill University | Phase 1 / Phase 2 |
| Active Not Recruiting | Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients with AL NCT04745299 | Corestemchemon, Inc. | Phase 3 |
| Completed | RT001 in Amyotrophic Lateral Sclerosis NCT04762589 | Biojiva LLC | Phase 2 |
| Completed | Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis NCT04632225 | Helixmith Co., Ltd. | Phase 2 |
| Recruiting | China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese Medicine NCT04885374 | Dongzhimen Hospital, Beijing | — |
| Completed | Geometrical Facial Deformation According to Posture in Amyotrophic Lateral Sclerosis NCT04798183 | Pusan National University Yangsan Hospital | — |
| Unknown | Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - C NCT04686110 | University Hospital, Angers | N/A |
| Withdrawn | Fatigue in Patients With Amyotrophic Lateral Sclerosis NCT04468191 | Cara Donohue | N/A |
| Recruiting | Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients NCT03127267 | AB Science | Phase 3 |
| Active Not Recruiting | To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy Volunteers NCT03651349 | Everfront Biotech Co., Ltd. | Phase 1 |
| Completed | Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS) NCT04569435 | Annexon, Inc. | Phase 2 |
| Active Not Recruiting | Phenotype, Genotype and Biomarkers 2 NCT04875416 | University of Miami | — |
| Completed | Exploratory Evaluation of [11C]MPC6827 NCT04575727 | Columbia University | EARLY_Phase 1 |
| Unknown | Home Care Needs and Current Nursing Status of Patients With Amyotrophic Lateral Sclerosis NCT04953481 | Peking University Third Hospital | — |
| Withdrawn | Food Supplement for the Treatment of Patients With Amyotrophic Lateral Sclerosis NCT02588807 | Herb Spirit | Phase 1 |
| Completed | Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS NCT05003167 | Purdue University | N/A |
| Completed | HEALEY ALS Platform Trial - Regimen D Pridopidine NCT04615923 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Unknown | The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALS NCT04651855 | Polski Bank Komorek Macierzystych JSC (PBKM) | Phase 1 / Phase 2 |
| Completed | A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS) NCT04516096 | Amylyx Pharmaceuticals Inc. | Phase 2 / Phase 3 |
| Unknown | Neurofilament Light Chain in Amyotrophic Lateral Sclerosis NCT06201650 | Charite University, Berlin, Germany | — |
| Unknown | The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS NCT04391361 | Ruijin Hospital | Phase 2 |
| Completed | Multiple Doses of AT-1501-A201 in Adults With ALS NCT04322149 | Anelixis Therapeutics, LLC | Phase 2 |
| Completed | COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry NCT04559009 | Wake Forest University Health Sciences | — |
| Completed | Evaluation of Palliative Care for Patients With ALS and Their Caregivers NCT04257760 | Ottawa Hospital Research Institute | N/A |
| Active Not Recruiting | The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS. NCT04562831 | Haukeland University Hospital | N/A |
| Terminated | MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Scle NCT04579666 | Apellis Pharmaceuticals, Inc. | Phase 2 |
| Terminated | A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With NCT04494256 | Biogen | Phase 1 / Phase 2 |
| Recruiting | Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part. NCT04882904 | Centre Hospitalier Universitaire de Liege | N/A |
| Completed | Open Label Study: Treatment of ALS Fatigue With PolyMVA NCT04557410 | University of Missouri-Columbia | Phase 1 |
| Terminated | A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease NCT04428775 | AZTherapies, Inc. | Phase 2 |
| Completed | The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)" NCT04305639 | Istanbul Medeniyet University | — |
| Recruiting | Analysis of Human ALS Tissues and Registry of ALS Patients NCT05067179 | University of Illinois at Chicago | — |
| Unknown | Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis NCT04518540 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | Investigation on Home Care Needs of ALS Patients and Their Caregivers NCT04950231 | Peking University Third Hospital | — |
| Recruiting | AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis NCT04721717 | University of Alabama at Birmingham | — |
| Completed | Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) NCT04499963 | Richard Bedlack, M.D., Ph.D. | Phase 2 |
| Unknown | Appetite and Related Factors in Patients With ALS NCT04953624 | Peking University Third Hospital | — |
| Unknown | Sleep Disorders and the Onset and Progression of ALS NCT04952038 | Peking University Third Hospital | — |
| Completed | HEALEY ALS Platform Trial - Regimen C CNM-Au8 NCT04414345 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Completed | HEALEY ALS Platform Trial - Regimen A Zilucoplan NCT04436497 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Completed | HEALEY ALS Platform Trial - Regimen B Verdiperstat NCT04436510 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Active Not Recruiting | Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients NCT03766321 | Azienda Ospedaliero-Universitaria di Modena | N/A |
| Unknown | Efficacy and Safety of Nitrazine in the Treatment of ALS NCT04950647 | Peking University Third Hospital | Phase 2 |
| Recruiting | HEALEY ALS Platform Trial - Master Protocol NCT04297683 | Merit E. Cudkowicz, MD | Phase 2 / Phase 3 |
| Unknown | The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granules NCT04950933 | Peking University Third Hospital | Phase 2 / Phase 3 |
| Unknown | Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). NCT04393467 | Campus Bio-Medico University | N/A |
| Active Not Recruiting | Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients Wi NCT04057898 | MediciNova | Phase 2 / Phase 3 |
| Terminated | Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Admin NCT04288856 | Biogen | Phase 1 |
| Active Not Recruiting | NuroSleeve Powered Brace & Stimulation System to Restore Arm Function NCT04798378 | Thomas Jefferson University | N/A |
| Terminated | Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclero NCT04326283 | Genuv Inc. | Phase 1 / Phase 2 |
| Completed | The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT NCT04051333 | Massachusetts General Hospital | — |
| Terminated | An Efficacy and Safety Study of Ravulizumab in ALS Participants NCT04248465 | Alexion Pharmaceuticals, Inc. | Phase 3 |
| Unknown | Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Mainland China NCT04328675 | Peking University Third Hospital | — |
| Completed | Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001 NCT04313166 | Collaborative Medicinal Development Pty Limited | Phase 2 |
| Withdrawn | A Study to Explore the Role of Gut Flora in ALS NCT04150809 | ProgenaBiome | — |
| Recruiting | ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) NCT04363684 | Mayo Clinic | — |
| Withdrawn | 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Scler NCT03843710 | Clene Nanomedicine | Phase 2 |
| Completed | Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis NCT04245709 | Dwight Koeberl, M.D., Ph.D. | Phase 2 |
| Completed | New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways. NCT03984708 | University Hospital, Tours | N/A |
| Terminated | Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients NCT04226144 | Escola Superior de Ciencias da Saude | N/A |
| Unknown | Low Dose IL-2 in the Treatment of Immune-associated ALS Syndrome NCT04952155 | Peking University Third Hospital | Phase 2 |
| Terminated | Study of Safety and Proof of the Mechanism of BLZ945 in ALS Patients NCT04066244 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS) NCT04098406 | Clene Nanomedicine | Phase 2 |
| Terminated | Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients NCT03377309 | American University of Beirut Medical Center | Phase 2 |
| Completed | Safety and Tolerability Ultra-high-caloric Food Supplements in Amyotrophic Lateral Sclerosis (ALS) NCT04172792 | Albert Christian Ludolph, Prof. | Phase 1 |
| Completed | Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALS NCT04165850 | NeuroSense Therapeutics Ltd. | Phase 2 |
| Withdrawn | Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral Sclerosis NCT03892382 | Jagiellonian University | N/A |
| Withdrawn | Repetitive Transcranial Magnetic Stimulation as Therapy for Depression in Amyotrophic Lateral Sclerosis NCT03892863 | Jagiellonian University | N/A |
| Recruiting | Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) NCT04454892 | Peking University Third Hospital | — |
| Completed | Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS NCT03851302 | Bronx VA Medical Center | N/A |
| Unknown | Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS) NCT04259255 | Tanabe Pharma America, Inc. | — |
| Unknown | A Study to Evaluate AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) NCT03981536 | AL-S Pharma | Phase 1 |
| Recruiting | Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone NCT04097158 | Loma Linda University | — |
| Unknown | CuATSM Compared With Placebo for Treatment of ALS/MND NCT04082832 | Collaborative Medicinal Development Pty Limited | Phase 2 / Phase 3 |
| Terminated | Arimoclomol in Amyotropic Lateral Sclerosis - Open Label Extension Trial NCT03836716 | ZevraDenmark | Phase 3 |
| Completed | Italian Validation of the Beaumont Behavioural Inventory (BBI) NCT04440644 | Istituti Clinici Scientifici Maugeri SpA | — |
| Withdrawn | IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS) NCT03474263 | Implicit Bioscience | Phase 2 |
| Unknown | Multimodal Brain Imaging Study NCT04960540 | Peking University Third Hospital | — |