NCT04691011

New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 22 (actual)
• Sponsor: Assistance Publique Hopitaux De Marseille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Amyotrophic lateral sclerosis (ALS) is a disabling and rapidly progressive neurodegenerative disorder. There is no treatment that significantly slows progression. Our project aims to find new biomarkers in MRI at three levels: cerebral, medullary and muscular. These markers could allow an earlier diagnosis of the disease by showing more specific lesions of ALS and to quantify these lesions to measure the progression of the disease. This study will use advanced Magnetic Resonance Imaging (MRI) techniques High field (3T) and very high field (7T) MRI. Results from neurological and electrophysiological tests will be compared to the MRI. Subjects will be recruited from ALS center of Marseille, France. MRI will be done on ALS patients at baseline, at 3 month and at 6 month intervals.

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

Type	Name	Description
OTHER	Muscular MRI	MRI (1.5T)
OTHER	Electrophysiological exam	MUNIX
OTHER	Brain MRI	MRI (7T)
OTHER	Spinal cord MRI	7T and 3T MRI

Timeline

• Start date: 2021-06-16
• Primary completion: 2025-06-04
• Completion: 2025-06-04
• First posted: 2020-12-31
• Last updated: 2026-01-30

Locations

1 site across 1 country: France