NCT04952038

Sleep Disorders and the Onset and Progression of ALS

Effect of Sleep Disorder on Onset and Progression of Amyotrophic Lateral Sclerosis

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

200 cases of ALS patients were collected to explore whether sleep disorders are related to earlier onset age, and whether sleep disorders accelerate the progress of ALS and shorten the survival time of ALS patients.

Detailed description

200 patients with ALS were collected. 1) sleep disorders were assessed by Pittsburgh sleep quality index (PSQI) and Epworth Sleepiness Scale (epworth) at baseline Sleeping Scale，ESS）； 2) Name, age, gender and onset site were collected to explore whether sleep disorders were associated with earlier onset age; 3) The patients' function (ALSFRS-R) at baseline and every 3 months within 2 years were collected, and the end-point time (death and invasive breathing) was recorded to evaluate whether sleep disturbance accelerated the decline of patients' function and shortened their short-term survival.

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

Type	Name	Description
BEHAVIORAL	sleep disorder	ALS patients with or without sleep disorder

Timeline

• Start date: 2020-08-01
• Primary completion: 2021-12-31
• Completion: 2022-03-31
• First posted: 2021-07-07
• Last updated: 2021-07-07

Locations

1 site across 1 country: China