NCT06318598

Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis

Dissezione Fenotipica Guidata da Biomarcatori Della Sclerosi Laterale Amiotrofica/Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Istituto Auxologico Italiano · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are: * Which set of biomarkers explain genotypic-phenotypic correlations in ALS? * Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups? Participants will undergo: * neurological evaluation * neurophysiological evaluation * neuropsychological evaluation * whole exome sequencing * biomarker measurement in CSF and plasma

Conditions

• Amyotrophic Lateral Sclerosis
• Motor Neuron Disease

Timeline

• Start date: 2023-04-11
• Primary completion: 2026-04-10
• Completion: 2026-04-10
• First posted: 2024-03-19
• Last updated: 2025-05-07

Locations

3 sites across 1 country: Italy