| Not Yet Recruiting | Functional Outcomes and Control Using Synchron BCI - Australia NCT07533903 | Synchron, Inc. | N/A |
| Recruiting | Functional Outcomes and Control Using Synchron BCI - Canada NCT07446114 | Synchron, Inc. | N/A |
| Active Not Recruiting | Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS) NCT07204977 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 |
| Not Yet Recruiting | Safety of Intrathecal Riluzole in Patients With Amyotrophic Lateral Sclerosis NCT07093268 | Brain Trust Bio | Phase 1 |
| Recruiting | GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Contr NCT07127172 | Neuralink Corp | N/A |
| Recruiting | Impact of Physical Functioning on Patient-Reported Outcomes in ALS Patients at TidalHealth NCT07491484 | TidalHealth, Inc. | — |
| Not Yet Recruiting | MRG-001 in Patients With Amyotrophic Lateral Sclerosis NCT06315608 | MedRegen LLC | Phase 2 |
| Recruiting | UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of NCT06992596 | Neuralink Corp | N/A |
| Not Yet Recruiting | Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis NCT06541873 | IRCCS San Raffaele | — |
| Recruiting | Digital App for Speech & Health Monitoring NCT06450418 | University of Edinburgh | — |
| Unknown | Technical Evaluation of Earswitch Phase B NCT06090448 | University of Bath | N/A |
| Completed | An Open Label Extension Study of Monepantel in Individuals With Motor Neurone Disease NCT06177431 | Neurizon Therapeutics Limited | Phase 1 |
| Recruiting | Emotion Processing Among Patients With ALS NCT06566651 | University of Aarhus | — |
| Unknown | Technical Evaluation of Earswitch Phase A NCT05784727 | University of Bath | N/A |
| Recruiting | Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families NCT05744310 | Haukeland University Hospital | N/A |
| Recruiting | Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis NCT06318598 | Istituto Auxologico Italiano | — |
| Recruiting | Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases NCT06318585 | Istituto Auxologico Italiano | — |
| Active Not Recruiting | Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used NCT04380649 | Centre Hospitalier Universitaire de Nice | N/A |
| Unknown | Rehabilitation in SOD1 ALS Treated With Tofersen NCT05725759 | Washington University School of Medicine | — |
| Recruiting | Virtual Peer-to-peer Support Programme for Carers of MND NCT04695210 | King's College London | N/A |
| Completed | A Study of Monepantel in Individuals With Motor Neurone Disease NCT04894240 | Neurizon Therapeutics Limited | Phase 1 |
| Recruiting | Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) NCT05354622 | Boston Children's Hospital | — |
| Recruiting | Awareness Detection and Communication in Disorders of Consciousness NCT03827187 | University of Ulster | N/A |
| Recruiting | Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA) NCT04944940 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Withdrawn | IC14 for Treatment of Amyotrophic Lateral Sclerosis NCT03508453 | Implicit Bioscience | Phase 2 |
| Completed | Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) NCT04788745 | The University of Queensland | Phase 2 |
| Enrolling By Invitation | Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China NCT04961450 | Peking University Third Hospital | — |
| Recruiting | Non-invasive BCI-controlled Assistive Devices NCT05183152 | University of Texas at Austin | N/A |
| Completed | Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorder NCT04939818 | Novoic Limited | — |
| Recruiting | Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures NCT05137665 | Target ALS Foundation, Inc. | — |
| Unknown | EMERALD TRIAL Open Label Extension Study NCT04997954 | Gold Coast Hospital and Health Service | Phase 4 |
| Completed | Virtual Reality in Motor Neurone Disease NCT06256107 | Lancashire Teaching Hospitals NHS Foundation Trust | N/A |
| Unknown | Neurofilament Light Chain in Amyotrophic Lateral Sclerosis NCT06201650 | Charite University, Berlin, Germany | — |
| Terminated | MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Scle NCT04579666 | Apellis Pharmaceuticals, Inc. | Phase 2 |
| Completed | Respiratory Complications in ALS NCT04430686 | Liverpool University Hospitals NHS Foundation Trust | — |
| Withdrawn | A Study to Explore the Role of Gut Flora in ALS NCT04150809 | ProgenaBiome | — |
| Completed | Surface EMG and Ultrasound in MND NCT05314348 | King's College Hospital NHS Trust | N/A |
| Completed | Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis NCT03929068 | Washington University School of Medicine | Phase 1 |
| Terminated | A Safety and Tolerability Study of ILB® in Patients With Amyotrophic Lateral Sclerosis (ALS) NCT03705390 | University of Birmingham | Phase 2 |
| Unknown | Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease NCT03690791 | Gold Coast Hospital and Health Service | Phase 3 |
| Completed | Study of ALS Reversals 4: LifeTime Exposures NCT03706391 | Duke University | — |
| Unknown | Validation Of Tidal/End -Tidal CO2 in ALS NCT03764384 | Papworth Hospital NHS Foundation Trust | — |
| Unknown | Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease NCT04240925 | Ospedale San Raffaele | N/A |
| Withdrawn | Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic NCT03664206 | Sándor Beniczky | — |
| Unknown | [BrainConnexion] - Neurodevice Phase I Trial NCT03811301 | National Neuroscience Institute | N/A |
| Completed | Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease NCT03487263 | Implicit Bioscience | Phase 1 |
| Recruiting | Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases NCT04706234 | Kliniken Beelitz GmbH | — |
| Completed | The General Breathing Record Study NCT03356288 | TidalSense | — |
| Terminated | A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps. NCT03196375 | Flex Pharma, Inc. | Phase 2 |
| Completed | Serial Fasciculation Measurements in Motor Neurone Disease NCT03809845 | King's College Hospital NHS Trust | N/A |
| Completed | AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) NCT03127514 | Amylyx Pharmaceuticals Inc. | Phase 2 |
| Completed | MN4000 for Treatment of CF and MND Patients in the Home Setting NCT03797677 | Hill-Rom | N/A |
| Completed | Deep Phenotyping in Patients With ALS NCT02819765 | Barrow Neurological Institute | — |
| Completed | Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND NCT02870634 | Collaborative Medicinal Development Pty Limited | Phase 1 |
| Recruiting | Novel MRI Biomarkers for Monitoring Disease Progression in ALS NCT03362658 | University of Alberta | — |
| Unknown | Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease NCT03067857 | Stem Cells Arabia | Phase 1 / Phase 2 |
| Completed | Effect of MD1003 in Amyotrophic Lateral Sclerosis NCT03114215 | MedDay Pharmaceuticals SA | Phase 2 |
| Recruiting | Amyotrophic Lateral Sclerosis and the Innate Immune System NCT02869048 | Rigshospitalet, Denmark | — |
| Completed | EncoreAnywhere Use in Motor Neurone Disease NCT03154450 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | Answer ALS: Individualized Initiative for ALS Discovery NCT02574390 | Johns Hopkins University | — |
| Completed | A Trial of Tocilizumab in ALS Subjects NCT02469896 | Barrow Neurological Institute | Phase 2 |
| Completed | Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases NCT02532244 | Nemours Children's Clinic | — |
| Completed | Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Patients NCT02987413 | Hospital e Maternidade Dr. Christóvão da Gama | Phase 1 |
| Unknown | Study of Predictive Factors of Progression of Motor Neurone Disease NCT02360891 | University Hospital, Lille | — |
| Recruiting | ALS Research Collaborative NCT06885918 | ALS Therapy Development Institute | — |
| Completed | Telehealth in Motor Neurone Disease NCT02464748 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy NCT02124057 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Completed | LIME Study (LFB IVIg MMN Efficacy Study) NCT01951924 | Laboratoire français de Fractionnement et de Biotechnologies | Phase 3 |
| Completed | Study of Electrical Impedance Myography (EIM) in ALS NCT02011204 | Skulpt, Inc. | — |
| Recruiting | Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers NCT01900132 | National Institute of Neurological Disorders and Stroke (NINDS) | N/A |
| Completed | Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease NCT01776970 | Ospedale San Raffaele | Phase 2 / Phase 3 |
| Completed | Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Scl NCT01758510 | Hanyang University Seoul Hospital | Phase 1 |
| Completed | A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers NCT01495390 | Massachusetts General Hospital | — |
| Completed | Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy NCT01369901 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 / Phase 2 |
| Completed | Oxidative Stress in Motor Neuron Disease: COSMOS Add-On Study NCT01143428 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Withdrawn | Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Diso NCT01459302 | University of Massachusetts, Worcester | — |
| Completed | Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis NCT00956488 | Wake Forest University Health Sciences | Phase 1 / Phase 2 |
| Enrolling By Invitation | Genetic Diagnosis in Inborn Errors of Metabolism NCT06376279 | Region Stockholm | — |
| Terminated | Pennsylvania Consortium: Clinical Database NCT00718445 | Drexel University College of Medicine | — |
| Terminated | Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral Sclerosis NCT00537446 | Columbia University | N/A |
| Completed | Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patien NCT00718497 | Drexel University College of Medicine | — |
| Completed | EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) NCT00718458 | Drexel University College of Medicine | — |
| Completed | Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS) NCT00718393 | Drexel University College of Medicine | — |
| Completed | Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) NCT00537641 | Columbia University | — |
| Completed | Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program NCT00716131 | Drexel University College of Medicine | — |
| Completed | Cerebrospinal Fluid Repository NCT00714636 | Drexel University College of Medicine | — |
| Completed | Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease NCT00324454 | Duke University | Phase 2 |
| Terminated | Satisfaction Survey for Amyotrophic Lateral Sclerosis (ALS) Patients Comparing Rooms With and Without Assistiv NCT00718107 | Drexel University College of Medicine | — |
| Terminated | Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS). NCT00718003 | Drexel University College of Medicine | — |
| Terminated | Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) Patient NCT00718016 | Drexel University College of Medicine | — |
| Completed | Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function NCT00076687 | Allergan | Phase 2 |
| Completed | Brain Function in Primary Lateral Sclerosis NCT00071435 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Recruiting | Study of Inherited Neurological Disorders NCT00004568 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Completed | Magnetic Stimulation of the Human Nervous System NCT00001780 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Completed | Ultrasound and Videofluoroscopy for Diagnosing Swallowing Disorders NCT00001220 | National Institutes of Health Clinical Center (CC) | — |