NCT04961450

Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China

A Study on the Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 2,500 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

1. To investigate the biomarkers of MND/FTD spectrum disease 2. To explore the possible pathogenesis of MND/FTD

Detailed description

Motor neuron disease (MND) is a group of disease characterized by motor neuron disorders and neurodegeneration. MND and frontotemporal dementia (FTD) were believed to comprise a neurodegenerative disease spectrum. The prognosis of the disease spectrum varies according to the type of disease, and the diagnosis of patients is often delayed due to insufficient diagnostic biomarkers. In recent years, the academic community has made significant progress in the study of biomarkers of the disease, but there is still a lack of specific biomarkers with strong diagnostic value. Besides, the low prevalence makes it difficult to carry out studies with large samples. The aim of this study was to explore diagnostic biomarkers of the disease spectrum by collecting variable samples from a large group of patients. The findings will both offer a better understanding of MND/FTD spectrum disease and also support the development of a model to study other rare diseases.

Conditions

• Amyotrophic Lateral Sclerosis
• Frontotemporal Dementia
• Motor Neuron Disease

Timeline

• Start date: 2021-06-24
• Primary completion: 2030-12-31
• Completion: 2030-12-31
• First posted: 2021-07-14
• Last updated: 2021-07-14

Locations

1 site across 1 country: China