| Enrolling By Invitation | Research Study for Patients With Neurological Diseases Which Evaluates the Patient Experience of the MemorEM D NCT07222605 | eQ8Health Corporation d/b/a CareONE Concierge | N/A |
| Recruiting | STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners NCT06613204 | Oregon Health and Science University | N/A |
| Recruiting | Vortioxetine for the Treatment of Mood and Cognitive Symptoms in Frontotemporal Dementia NCT06604520 | Johns Hopkins University | Phase 2 |
| Active Not Recruiting | Music, Social Attention, and Dementia NCT06768996 | University of California, San Francisco | N/A |
| Completed | Study in Asymptomatic GRN-FTD Patients to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmaco NCT06705192 | Mads Kjolby | Phase 1 |
| Recruiting | Using the EHR to Advance Genomic Medicine Across a Diverse Health System NCT06377033 | University of Pennsylvania | N/A |
| Unknown | The Clinical Impact of the Novel Alzheimer's Blood-based Biomarkers NCT06246019 | Hospital del Mar Research Institute (IMIM) | — |
| Withdrawn | Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS NCT05830214 | University of Alberta | — |
| Recruiting | Proteinopathies Expression in Skin of Neurodegenerative Disorders NCT06528964 | Universidad Autonoma de San Luis Potosí | — |
| Recruiting | Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial NCT06093126 | Nova Scotia Health Authority | Phase 4 |
| Recruiting | Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and NCT06529744 | University Health Network, Toronto | — |
| Recruiting | A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-t NCT06064890 | AviadoBio Ltd | Phase 1 / Phase 2 |
| Active Not Recruiting | A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration (FTLD) Syndromes NCT05956834 | Massachusetts General Hospital | — |
| Completed | Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers NCT05916664 | Kinto | N/A |
| Recruiting | Genetic Frontotemporal Dementia Initiative for Neurodevelopment NCT05779813 | Western University | — |
| Recruiting | Nabilone for Agitation in Frontotemporal Dementia NCT05742698 | Simon Ducharme, MD | Phase 2 |
| Active Not Recruiting | A Study of Caregiver Connections Via Technology in Dementia NCT05779839 | Mayo Clinic | N/A |
| Unknown | Stories in the Moment: Dance Program for People Living With Dementia NCT06221202 | DanceStream Projects | N/A |
| Completed | Autobiographical Specificity NCT05642351 | Nantes University Hospital | — |
| Completed | Long-term Effect of TMS in Primary Progressive Aphasia NCT05842473 | Hospital San Carlos, Madrid | N/A |
| Completed | The Care Ecosystem Consortium Effectiveness Study NCT05669365 | University of California, San Francisco | N/A |
| Unknown | Subgenual Cingulate Deep Brain STIMulation for Apathetic Behavioral Variant FRONtotemporal Dementia NCT05699330 | University Health Network, Toronto | N/A |
| Completed | Group-Based Telehealth Music Therapy Intervention for Patients With Dementia: A Pilot Study NCT05508646 | Geisinger Clinic | N/A |
| Recruiting | Non-invasive Neurostimulation as a Tool for Diagnostics and Management for Neurodegenerative Diseases NCT05326750 | Kuopio University Hospital | N/A |
| Recruiting | NYSCF Scientific Discovery Biobank NCT06203106 | New York Stem Cell Foundation Research Institute | — |
| Recruiting | Tanycytes in Alzheimer's Disease and Frontotemporal Dementia NCT05288842 | University Hospital, Lille | — |
| Withdrawn | A Study to Evaluate Caregiver Connections Via Technology for Patients With Alzheimer's and Other Types of Deme NCT05497817 | Mayo Clinic | N/A |
| Completed | A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research NCT05444244 | University of Wisconsin, Madison | N/A |
| Active Not Recruiting | The Safety and The Efficacy Evaluation of ET-STEM in Patients With Frontotemporal Dementia NCT05315661 | Samsung Medical Center | Phase 1 |
| Completed | Better Living With Non-memory-led Dementia NCT05525377 | University College, London | N/A |
| Completed | Neurological Soft Signs in Neurodegenerative Dementias NCT06354933 | University of Milano Bicocca | — |
| Active Not Recruiting | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Part NCT05262023 | Denali Therapeutics Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register S NCT06209515 | Kuopio University Hospital | — |
| Completed | WeCareAdvisor Study for Caregivers of People Living With Dementia NCT05012410 | Drexel University | N/A |
| Recruiting | First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia NCT05374278 | David Wilson | Phase 1 / Phase 2 |
| Completed | A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD NCT04993755 | Transposon Therapeutics, Inc. | Phase 2 |
| Recruiting | A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes NCT04747431 | Passage Bio, Inc. | Phase 1 / Phase 2 |
| Completed | Epidemiological Study in FRONtoTemporal Dementia NCT05075187 | CENTOGENE GmbH Rostock | — |
| Unknown | Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality o NCT05004558 | Drexel University | N/A |
| Completed | Mindfulness-Based Stress Reduction in Dementia Caregivers NCT04977245 | University of California, San Francisco | N/A |
| Completed | Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (P NCT04165213 | University of Pennsylvania | N/A |
| Enrolling By Invitation | Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China NCT04961450 | Peking University Third Hospital | — |
| Completed | Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorder NCT04939818 | Novoic Limited | — |
| Completed | Dopaminergic Therapy for Frontotemporal Dementia Patients NCT04937452 | I.R.C.C.S. Fondazione Santa Lucia | Phase 2 |
| Completed | Support Via Technology: Living and Learning With Advancing FTD NCT05338710 | Oregon Health and Science University | N/A |
| Active Not Recruiting | Phenotype, Genotype and Biomarkers 2 NCT04875416 | University of Miami | — |
| Unknown | Gamma-Induction in FrontoTemporal Dementia Trial NCT04425148 | Massachusetts General Hospital | N/A |
| Unknown | Tau Protein and SV2a Imaging in Patients With Tau Protein-related Diseases NCT05260151 | Xuanwu Hospital, Beijing | — |
| Active Not Recruiting | Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD NCT04408625 | Prevail Therapeutics | Phase 1 / Phase 2 |
| Active Not Recruiting | Neurofilament Surveillance Project (NSP) NCT04516499 | The Bluefield Project to Cure Frontotemporal Dementia | — |
| Terminated | A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3) NCT04374136 | Alector Inc. | Phase 3 |
| Completed | Feasibility of Passive Data Collection in Dementia Subjects With Agitation NCT04413851 | HealthMode Inc. | — |
| Active Not Recruiting | Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD NCT04220021 | University of Florida | Phase 2 |
| Recruiting | Longitudinal Cognitive Assessment by BoCA NCT04114994 | Alzheimer's Light LLC | — |
| Completed | A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRON NCT03987295 | Alector Inc. | Phase 2 |
| Completed | Voices Of Individuals: Challenges and Experiences Of bvFTD NCT04060082 | University of Pennsylvania | — |
| Completed | Palmitoylethanolamide Combined With Luteoline in Frontotemporal Dementia Patients. A Randomized Controlled Tri NCT04489017 | I.R.C.C.S. Fondazione Santa Lucia | Phase 2 |
| Recruiting | GENetic Fronto Temporal Dementia Initiative in Lille NCT04639622 | University Hospital, Lille | N/A |
| Completed | The Music, Sleep and Dementia Study NCT04157244 | University of Pennsylvania | N/A |
| Completed | In-Home Technology for Dementia Caregivers NCT03828383 | University of California, Berkeley | N/A |
| Active Not Recruiting | TRIAL READY (Clinical Trial Readiness) NCT03912987 | University of Miami | — |
| Completed | Multimodal Ocular Imaging in Neurodegeneration NCT03699644 | University of Michigan | — |
| Completed | Connectomics in Psychiatric Classification NCT03967535 | Washington University School of Medicine | — |
| Completed | A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (G NCT03636204 | Alector Inc. | Phase 1 |
| Completed | Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Pr NCT03510572 | Asan Medical Center | EARLY_Phase 1 |
| Unknown | Intranasal Oxytocin for Frontotemporal Dementia NCT03260920 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |
| Completed | Cognitive, Behavioral, and Functional Change in Behavioral Variant Frontotemporal Dementia (bvFTD) NCT03088956 | Biogen | — |
| Completed | 18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls NCT03625128 | Chang Gung Memorial Hospital | EARLY_Phase 1 |
| Completed | RHAPSODY-plus: Online Counseling for Family Caregivers of Patients With Young Onset Dementia NCT03923517 | Technical University of Munich | N/A |
| Recruiting | Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal NCT03225144 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Recruiting | Retinal Imaging in Neurodegenerative Disease NCT03233646 | Duke University | — |
| Completed | Flortaucipir PET Imaging in Subjects With FTD NCT03040713 | Avid Radiopharmaceuticals | Phase 1 |
| Completed | More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease NCT03076671 | University of Colorado, Denver | N/A |
| Completed | Rehabilitative Trial for the Rescue of Neurophysiological Parameters in Progranulin Deficient Subjects NCT02999282 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Recruiting | Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias NCT02945774 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Recruiting | Neurologic Stem Cell Treatment Study NCT02795052 | MD Stem Cells | N/A |
| Completed | The Healthy Patterns Sleep Study NCT03682185 | University of Pennsylvania | Phase 3 |
| Completed | Efficacy of Web-Based Social-Cognitive Interventions in Right Hemisphere Stroke and Frontotemporal Dementia NCT02506036 | Johns Hopkins University | N/A |
| Completed | Quantitative Evaluation of Apathy Close to Real Life Situation by Means of a Multimodal Sensor System Integrat NCT02496312 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Enrolling By Invitation | Phenotype, Genotype & Biomarkers in ALS and Related Disorders NCT02327845 | University of Miami | — |
| Completed | Study of the Neural Basis of Analogical Reasoning NCT02236832 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Completed | The Ontario Neurodegenerative Disease Research Initiative NCT04104373 | Ontario Neurodegeneration Disease Research Initiative | — |
| Completed | Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family NCT02055092 | Norwegian Centre for Ageing and Health | — |
| Completed | Computational Tools for Early Diagnosis of Memory Disorders NCT02050464 | University of Eastern Finland | — |
| Completed | Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia NCT01937013 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |
| Completed | Communication Bridge Speech Therapy Research Study NCT02439853 | University of Chicago | N/A |
| Completed | Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrom NCT02819700 | Centre Hospitalier Universitaire, Amiens | — |
| Unknown | EEG and TMS-based Biomarkers of ALS, MS and FTD NCT04918251 | University of Dublin, Trinity College | — |
| Completed | Olfactory Deficits in Neurologic Disease NCT05019014 | Massachusetts General Hospital | — |
| Completed | Safety Study of Intranasal Oxytocin in Frontotemporal Dementia NCT01386333 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 1 |
| Completed | Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGN NCT00938665 | Neuronetrix, Inc. | — |
| Recruiting | Cerebro Spinal Fluid Collection (CSF) NCT04844060 | University Hospital, Strasbourg, France | — |
| Unknown | Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls NCT01147679 | University of California, Los Angeles | — |
| Completed | Oxytocin and Social Cognition in Frontotemporal Dementia NCT01002300 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and N NCT01890343 | Avid Radiopharmaceuticals | Phase 2 |
| Withdrawn | A Composite MR Neuroimaging Marker for Alzheimer's Disease NCT01615666 | Medical College of Wisconsin | — |
| Withdrawn | Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Diso NCT01459302 | University of Massachusetts, Worcester | — |
| Completed | COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE NCT02860338 | Clionsky Neuro Systems Inc. | — |
| Enrolling By Invitation | Imaging of Brain Amyloid Plaques in the Aging Population NCT00950430 | Mayo Clinic | Phase 4 |
| Recruiting | Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementi NCT01353430 | University of California, Irvine | — |
| Completed | Open Label Pilot Study of the Effects of Memantine on FDG-PET in Frontotemporal Dementia NCT00594737 | Tiffany Chow, MD | Phase 3 |
| Completed | Serotonergic Function and Behavioural and Psychological Symptoms of Frontotemporal Dementia NCT00376051 | Sunnybrook Health Sciences Centre | Phase 4 |
| Completed | A Pilot Study to Explore the Safety and Tolerability of Galantamine HBr in the Treatment of Pick Complex/Front NCT00416169 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 2 |
| Terminated | Amyotrophic Lateral Sclerosis and Frontotemporal Dementia NCT00159198 | Assistance Publique - Hôpitaux de Paris | — |
| No Longer Available | An Open-Label, Expanded Access Protocol of LAM-002A in C9ORF72-Associated Frontotemporal Dementia (FTD) NCT05483322 | OrphAI Therapeutics | — |