NCT05075187

Epidemiological Study in FRONtoTemporal Dementia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,287 (actual)
• Sponsor: CENTOGENE GmbH Rostock · Industry
• Sex: All
• Age: 25 Years – 85 Years
• Healthy volunteers: Accepted

Summary

An international, multicenter, epidemiological observational study aims to investigate the prevalence of genetic etiologies in patients diagnosed with FTD or clinically suspected for FTD.

Detailed description

Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous neurodegenerative disease caused by the loss or damage of nerve cells in the brain's frontal and temporal lobes. This leads to abnormalities in behaviour, personality, and language comprehension problems. Also, people with FTD show movement disorders like tremor, rigidity, difficulty in coordination, muscle spasms and weakness. FTD's etiology is sporadic or heritable. Sixty to 70% of FTD cases are sporadic, while 30 to 40% are inherited (familial aggregation). For this study, blood samples were collected from clinically diagnosed or suspected FTD patients and were analysed for a broad range of pathogenic variants in genes associated with FTD. The scientific insights acquired from this study will help identify novel therapeutic targets and develop/ investigate potential disease-modifying drugs.

Conditions

• Frontotemporal Dementia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Genetic Screening	Blood samples will be collected from clinically diagnosed or suspected FTD patients and will be analysed for a broad range of pathogenic variants in genes associated with FTD.

Timeline

• Start date: 2021-09-01
• Primary completion: 2024-01-09
• Completion: 2024-01-09
• First posted: 2021-10-12
• Last updated: 2026-04-09

Locations

37 sites across 7 countries: Belgium, Germany, Greece, Italy, Portugal, Spain, Turkey (Türkiye)