NCT04639622

GENetic Fronto Temporal Dementia Initiative in Lille

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

GENFI Lille is a French cohort that belongs to the international initiative GENFI2, a five year longitudinal biomarker cohort study of genetic FTD and its associated disorders (including MND/ALS) investigating members of families with a known mutation in GRN or MAPT or an expansion in C9orf72 (including those affected with the disorder as well as at-risk members of families).

Detailed description

The purposes of this study is : * to improve characterization of symptomatic FTD patients or presymptomatic subjects at risk of genetic FTD * to develop markers indicative of the optimal time to start disease-modifying therapy, based on the proximity to clinical onset. * to develop markers of disease progression that can be used as outcome measures. * to derive sample size estimates for clinical trials. Participants will include those affected with the disorder as well as at-risk members of families (both mutation carriers and non-carrier first-degree relatives who will serve as a control group). All participants will be assessed longitudinally with a set of clinical, neuropsychiatric, cognitive, imaging and biosample protocols.

Conditions

• Frontotemporal Dementia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Investigation procedures	All participants will be assessed longitudinally with a set of clinical evaluation, neuropsychiatric and cognitive assessments, imaging (MRI and PET scans) and biosample (CSF, blood samples)

Timeline

• Start date: 2019-04-23
• Primary completion: 2025-04-23
• Completion: 2026-04-23
• First posted: 2020-11-20
• Last updated: 2022-02-11

Locations

1 site across 1 country: France