NCT06354933

Neurological Soft Signs in Neurodegenerative Dementias

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 186 (actual)
• Sponsor: University of Milano Bicocca · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to investigate the prevalence of Neurological Soft Signs (NSS) in various categories of dementia patients compared to matched controls. The main questions it aims to answer are: * Does the prevalence of NSS significantly differ among patients with neurodegenerative dementias compared to controls? * Are NSS associated with neuropsychiatric alterations in dementia patients? * Do NSS correlate with cognitive screening tools? * Do NSS increase over time in patients with neurodegenerative dementias? Participants will undergo assessments including: * Evaluation of NSS using the Heidelberg scale * Neuropsychiatric assessments * Cognitive screening using the Mini-Mental State Examination (MMSE) and Frontal Assessment Battery (FAB) Researchers will compare dementia groups (Alzheimer's disease, Frontotemporal dementia, Corticobasal syndrome and Lewy body dementia) to controls to determine differences in NSS prevalence. Additionally, associations between NSS and neuropsychiatric symptoms, as well as cognitive performance, will be explored.

Conditions

• Alzheimer Disease
• Dementia With Lewy Bodies
• Frontotemporal Dementia
• Corticobasal Degeneration

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Neurological Soft Signs	Neurological Soft Signs score according to the Heidelberg Manual

Timeline

• Start date: 2022-04-01
• Primary completion: 2023-11-30
• Completion: 2024-02-01
• First posted: 2024-04-09
• Last updated: 2026-03-25

Locations

1 site across 1 country: Italy