NCT02945774

Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 30 Years – 95 Years
• Healthy volunteers: Accepted

Summary

Neuroinflammation is increasingly implicated as a potential critical pathogenic mechanism in a variety of neurologic and psychiatric disorders. This study will use hybrid PET/MRI imaging to evaluate neuroinflammation and its relationship to cerebral perfusion in frontotemporal dementia (FTD). Patients with FTD will be recruited from the Cognitive Neurology and Aging Brain clinics at Parkwood Institute and will undergo neurocognitive assessment and MRI/PET using the PET ligand FEPPA which binds to activated microglia, a marker of neuroinflammation. Correlations will be conducted to determine whether abnormal neuroinflammation is present in Frontotemporal dementia and whether differential patterns of neuroinflammation are present in different FTD clinical and molecular subtypes, and to determine the relationship between neuroinflammation, cerebral perfusion using arterial spin labeling MRI imaging techniques, and indices of brain structure including volumetric and white matter analysis.

Conditions

• Frontotemporal Dementia

Interventions

Type	Name	Description
RADIATION	(18F)-FEPPA	PET ligand that binds to activated microglia, a marker of neuroinflammation

Timeline

• Start date: 2016-08-01
• Primary completion: 2028-02-01
• Completion: 2029-08-01
• First posted: 2016-10-26
• Last updated: 2025-03-05

Locations

1 site across 1 country: Canada