NCT06396260

Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Aalborg University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).

Conditions

• Amyotrophic Lateral Sclerosis
• Pseudobulbar Affect

Interventions

Type	Name	Description
OTHER	Diffusion Kurtosis Imaging (DKI)	Non-invasive MRI sequence which extracts information of diffusion signals from complex brain tissue
OTHER	Resting State Magnetoencephalography	Non-invasive method of measuring resting state brain activity through magnetoencephalography (MEG)

Timeline

• Start date: 2024-05-26
• Primary completion: 2026-10-31
• Completion: 2026-12-31
• First posted: 2024-05-02
• Last updated: 2025-01-29

Locations

1 site across 1 country: Denmark