| Not Yet Recruiting | Penn SICCA Follow-up Study NCT05056012 | University of Pennsylvania | — |
| Not Yet Recruiting | R-2487 in Patients With Sjogren's Syndrome (SS) NCT06297213 | Rise Therapeutics LLC | Phase 1 |
| Recruiting | Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease NCT07281456 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Recruiting | Creating Health Course Study for People With Rheumatological Conditions NCT07180537 | Terry L. Wahls | N/A |
| Recruiting | An Exploratory Clinical Study of YTS109 Cell for R/R Autoimmune Diseases NCT07236762 | China Immunotech (Beijing) Biotechnology Co., Ltd. | Phase 1 |
| Recruiting | A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Dis NCT07041099 | Cullinan Therapeutics Inc. | Phase 1 |
| Recruiting | Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis NCT07301892 | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | — |
| Recruiting | Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Dise NCT06842316 | Centre Hospitalier Régional d'Orléans | — |
| Recruiting | Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome NCT06771427 | Taipei Veterans General Hospital, Taiwan | — |
| Recruiting | Clinical Study on Targeted CD19 or CD19-BCMA CAR-T Therapy for Autoimmune Diseases NCT06548607 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Suspended | Clinical Study on Targeted CD19CAR-T Therapy for Autoimmune Diseases NCT06549296 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Not Yet Recruiting | Diagnostic Interest of the Buccal Schirmer Test in Xerostomia During Sjögren's Syndrome: XERODIAG NCT06530940 | University Tunis El Manar | — |
| Recruiting | Fourth-gen CAR T Cells Targeting BCMA/CD19 for Refractory Systemic Lupus Erythematosus (SLE) NCT06350110 | Essen Biotech | Phase 1 / Phase 2 |
| Not Yet Recruiting | Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome NCT06475027 | Taipei Veterans General Hospital, Taiwan | — |
| Recruiting | Analyse of Inflammatory Activity of Sjögren's Syndrome on 68Ga-FAPI PET-CT NCT07062523 | Peking Union Medical College Hospital | Phase 1 / Phase 2 |
| Terminated | Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye NCT06364657 | Johns Hopkins University | — |
| Completed | The Role of Central Sensitization on Biopsychosocial Factors in Primary Sjögren's Syndrome NCT06410742 | Kahramanmaras Sutcu Imam University | — |
| Recruiting | Histopathological Analysis Versus Full-field Optical Coherence Tomography of Minor Salivary Gland Biopsy in Su NCT06454370 | Centre Hospitalier de Mâcon | — |
| Recruiting | Reliability, Validity, and Responsiveness of the Turkish Version of Eating Assessment Tool-10 for Patients Wit NCT06401811 | Kahramanmaras Sutcu Imam University | — |
| Recruiting | Sequential CAR-T Cells Targeting BCMA/CD19 in Patients With Relapsed/ Refractory Autoimmune Diseases NCT06428188 | Essen Biotech | Phase 1 / Phase 2 |
| Not Yet Recruiting | The Safety and Efficacy of Anti-CD19 CAR-T Cells in Patients With Relapsed/Refractory Autoimmune Diseases NCT06420154 | First Affiliated Hospital of Wenzhou Medical University | EARLY_Phase 1 |
| Not Yet Recruiting | Preliminary Clinical Study of UTAA09 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases NCT06417398 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | EARLY_Phase 1 |
| Active Not Recruiting | A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome NCT06312020 | Amgen | Phase 2 |
| Recruiting | An Clinical Study of YTS109 Cell Injection in Subjects With Recurrent/Refractory Autoimmune Disease NCT06379646 | China Immunotech (Beijing) Biotechnology Co., Ltd. | N/A |
| Recruiting | Anti-CD19-CD3E-CAR-T Cells in Relapsed/Refractory Autoimmune Disease NCT06373081 | Shanghai Changzheng Hospital | N/A |
| Unknown | EVADRY® in the Treatment of Xerostomia in Sjögren's Syndrome NCT06313905 | University Tunis El Manar | N/A |
| Recruiting | Belimumab After Rituximab in Resistant Primary Juvenile SS NCT06410833 | Peking Union Medical College Hospital | Phase 4 |
| Recruiting | Rheumatology Diet Study NCT06339957 | University of Central Florida | — |
| Active Not Recruiting | Ro60 Expression in Macrophages in Sjogren's Disease NCT06324968 | Centre Hospitalier Universitaire de Nice | N/A |
| Active Not Recruiting | A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With M NCT06104124 | Amgen | Phase 3 |
| Recruiting | An AI Algorithm for Lymphocyte Focus Score of Minor Salivary Gland Biopsy Samples for Diagnosing Sjogren's Syn NCT06437652 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Recruiting | Functional Analysis of Salivary Glands and Correlation With Sialoscintigraphy in Sjogren's Syndrome NCT06536075 | National Taiwan University Hospital | N/A |
| Recruiting | Safety and Efficacy of CD19 Targeted CAR-T Therapy for Refractory Autoimmune Disease NCT06056921 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Completed | Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism NCT05961267 | University Hospital, Bordeaux | — |
| Recruiting | Assessment of Physician Consideration of EPRO's, from Patients with Gout, Rheumatoid Arthritis, Sjogren's Synd NCT05927688 | University Hospital, Strasbourg, France | — |
| Recruiting | Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome NCT06406933 | Chang Gung Memorial Hospital | — |
| Recruiting | Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases NCT05904301 | Santé Arménie French-Armenian Research Center | — |
| Active Not Recruiting | Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases NCT05879419 | University of Sao Paulo General Hospital | Phase 4 |
| Enrolling By Invitation | Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases NCT05859997 | Bioray Laboratories | N/A |
| Completed | Nasal Spray Study in Sjogren's Dry Eye Disease NCT05700422 | University of Pennsylvania | Phase 4 |
| Completed | Assessing the Efficacy of a Carbamide Peroxide Mouthwash for Oral Wound Healing, Oral Hygiene and Xerostomia R NCT06363955 | National and Kapodistrian University of Athens | N/A |
| Completed | VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome NCT05656196 | Taipei Veterans General Hospital, Taiwan | N/A |
| Active Not Recruiting | Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity NCT05715463 | Brigham and Women's Hospital | N/A |
| Unknown | Ultrasound Characteristics of the Salivary Glands in Patients With Rheumatoid Arthritis NCT05782049 | University Hospital, Clermont-Ferrand | N/A |
| Recruiting | Wheat-free Diet in the Treatment of Sjogren's Syndrome NCT05644795 | University of Palermo | N/A |
| Unknown | Anifrolumab Treatment for 24 Weeks in Patients With Primary Sjögren's Syndrome NCT05383677 | University Medical Center Groningen | Phase 2 |
| Not Yet Recruiting | Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank NCT03938207 | Taipei Veterans General Hospital, Taiwan | — |
| Completed | Efficacy and Safety of Baricitinib in Sjogren's Syndrome NCT05016297 | Peking Union Medical College Hospital | Phase 2 |
| Unknown | Olfactory and Taste Disturbances in Sjogren's Syndrome NCT04909112 | Université de Reims Champagne-Ardenne | N/A |
| Completed | AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye NCT06013436 | Chengdu University of Traditional Chinese Medicine | — |
| Unknown | Fetal-Hope Study: Home Monitoring of Fetal Heart Rate in SSA+ Pregnant Women NCT05958446 | ASST Fatebenefratelli Sacco | — |
| Completed | Levocarnitine for Dry Eye in Sjogren's Syndrome NCT03953703 | Vanderbilt University Medical Center | Phase 2 |
| Unknown | A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome NCT05085431 | Zhejiang University | EARLY_Phase 1 |
| Unknown | Evaluation of Hand Functions in Newly Diagnosed Primary Sjögren's Syndrome NCT05115487 | Selcuk University | — |
| Completed | A Study of Nipocalimab in Adults With Primary Sjogren's Syndrome (pSS) NCT04968912 | Janssen Research & Development, LLC | Phase 2 |
| Completed | Fish Oil (Omega 3 ) in Sjogren's Syndrome NCT05005806 | Hawler Medical University | Phase 2 / Phase 3 |
| Completed | Prevalence and Factors of Sarcopenia and in Patients With Primary Sjogren's Syndrome NCT05015114 | Acibadem University | — |
| Completed | CEQUA for Sjogren's Syndrome Dry Eye NCT04835623 | Center for Ophthalmic and Vision Research, LLC | Phase 4 |
| Active Not Recruiting | Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome NCT04496960 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 1 / Phase 2 |
| Completed | Patients With Co-occurrence of ANCA Vasculitis and Sjögren Syndrome NCT04895878 | University Hospital, Montpellier | — |
| Suspended | Sjogren's Lung Study NCT04843345 | Stanford University | — |
| Completed | Superb Microvascular Imaging Ultrasonography of Lacrimal Gland in Patients With Sjögren Syndrome NCT05689749 | Nigde Omer Halisdemir University | — |
| Unknown | Beta-3 Agonist and Anti-muscarinic Agent for Sjogren's Syndrome With Overactive Bladder NCT04909255 | China Medical University Hospital | Phase 4 |
| Completed | the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia NCT04252209 | Cairo University | Phase 3 |
| Unknown | Polymyalgia Rheumatica Associated to Primary Sjogren Syndrome NCT05312944 | University Hospital, Brest | — |
| Unknown | Study of Leukocyte Populations in Patients With Chronic Inflammatory NCT04749875 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | COVID-19 Vaccination in Rheumatic Disease Patients NCT04839315 | Mayo Clinic | EARLY_Phase 1 |
| Completed | Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye NCT04493658 | Johns Hopkins University | — |
| Completed | Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome NCT04541589 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Fatigue in Primary Sjögren's Syndrome NCT04802577 | Bursa Yuksek Ihtisas Training and Research Hospital | — |
| Completed | Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fittin NCT04649177 | Boston Sight | N/A |
| Active Not Recruiting | Descriptive Study of Variations in Serum Translocation Markers of the Intestinal Microbiota in Patients With G NCT04462601 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (p NCT04572841 | Sanofi | Phase 2 |
| Completed | Hydroxychloroquine Blood Levels in Primary Sjögren Syndrome Patients NCT04546542 | University of Sao Paulo General Hospital | — |
| Completed | The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata NCT04239521 | Momentum Data | — |
| Recruiting | Rheumatology Patient Registry and Biorepository NCT04402086 | Yale University | — |
| Completed | Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome NCT03841318 | University Hospital, Bordeaux | N/A |
| Unknown | Prevalence and Seroconversion of COVID-19 in Autoimmune Diseases in Europe NCT04397237 | Pitié-Salpêtrière Hospital | — |
| Unknown | Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases NCT04530461 | faida agili | — |
| Completed | Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of NCT04345159 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Terminated | Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host NCT04313725 | Tangible Science | N/A |
| Recruiting | B-dependant Rare AutoImmune diseaSES - Cohort of Patients With Suspected Diagnosis of Primitive Sjögren Syndro NCT04931160 | University Hospital, Brest | N/A |
| Completed | A Prospective Pilot Study to Explore Efficacy and Safety of Baricitinib in Active Primary Sjogren's Syndrome P NCT04916756 | Peking Union Medical College Hospital | Phase 1 / Phase 2 |
| Unknown | Pilot Feasibility Study of a Sjögren's Syndrome Self-management App NCT04653935 | Northumbria University | N/A |
| Terminated | Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease NCT04143841 | Epitech Mag Ltd. | N/A |
| Completed | Cell Surface Marker Expression in Autoimmune Diseases NCT03757065 | Alpine Immune Sciences, Inc. | — |
| Completed | tDCS for Fatigue in Sjogren's Syndrome NCT04119128 | Federal University of São Paulo | N/A |
| Terminated | Smartphone Mindfulness Meditation for Patients With Rheumatic Diseases NCT03937856 | Johns Hopkins University | N/A |
| Completed | Fecal Microbial Transplant (FMT) for Sjogrens Syndrome NCT03926286 | University of Miami | Phase 1 |
| Completed | Effects of Acupuncture on Sjögren's Syndrome NCT04056221 | Ana Carolina Fragoso Motta, DDS, PhD | N/A |
| Completed | A Study to Evaluate VIB7734 in Participants With Systemic Lupus Erythematosus (SLE), Cutaneous Lupus Erythemat NCT03817424 | Amgen | Phase 1 |
| Completed | TrueTear in Sjogren's Disease Patients NCT03719885 | University of Pennsylvania | N/A |
| Active Not Recruiting | Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome NCT03711214 | University of Sao Paulo General Hospital | N/A |
| Unknown | Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye NCT03436576 | Pontificia Universidad Catolica de Chile | Phase 3 |
| Completed | Adelphi Primary Sjogren's Syndrome (pSS) Disease Specific Programme (DSP) NCT03501420 | GlaxoSmithKline | — |
| Completed | Oral Health Needs Assessment of Sjogren s Syndrome and Salivary Gland Dysfunction Cohorts and Healthy Voluntee NCT03327870 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases NCT03540823 | University of Sao Paulo General Hospital | Phase 4 |
| Recruiting | Meir Medical Center Rheumatologic Biobank NCT03473912 | Meir Medical Center | — |
| Completed | Yellow Fever Vaccine in Patients With Rheumatic Diseases NCT03430388 | University of Sao Paulo General Hospital | N/A |
| Completed | Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's S NCT03840538 | Cairo University | Phase 1 / Phase 2 |
| Recruiting | Maternal Autoimmune Disease Research Alliance (MADRA) Registry NCT03276923 | Duke University | — |
| Completed | Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye NCT03012698 | Epitech Mag Ltd. | N/A |
| Completed | Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases NCT03248518 | University of Aberdeen | N/A |
| Completed | Evaluation of the Prevalence of Functional Digestive Disorders During Primary Sjögren Gougerot Syndrome NCT03157011 | University Hospital, Limoges | N/A |
| Withdrawn | Clinical Performance of BioCLIA Ro60 NCT03204448 | HOB Biotech Group | — |
| Completed | Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren' NCT03100942 | Gilead Sciences | Phase 2 |
| Unknown | Study of Iguratimod in Sjögren's Syndrome NCT03023592 | Peking Union Medical College Hospital | Phase 1 / Phase 2 |
| Completed | A Study of RSLV-132 in Subjects With Primary Sjogren's Syndrome NCT03247686 | Resolve Therapeutics | Phase 2 |
| Unknown | Blood Based Eyedrops From Different Sources in the Treatment of Severe Keratopathy NCT03064984 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Completed | Topical Management of Xerostomia With Dry Mouth Products NCT03611283 | Rosa María López-Pintor Muñoz | N/A |
| Completed | A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome NCT02701985 | Hoffmann-La Roche | Phase 2 |
| Unknown | Sjogrens Syndrome Measured by Ultrasound NCT03411850 | Arthritis & Rheumatism Associates, P.C. | Phase 2 |
| Unknown | Acupuncture for Primary Sjögren Syndrome NCT02691377 | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Phase 2 |
| Completed | Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects Wi NCT02631538 | GlaxoSmithKline | Phase 2 |
| Unknown | Efficacy and Safety of Mycophenolate Mofetil in subjectswithSjogren's Syndrome NCT02691949 | Kaohsiung Medical University | Phase 2 |
| Recruiting | Ultra-High Frequency Ultrasonography in Sjögren's Syndrome NCT06338735 | University of Pisa | N/A |
| Completed | Interstitial Lung Diseases in Primary Sjogren's Syndrome NCT04978883 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Corneal Nerve Structure in Sjogren's NCT03203382 | University of Pennsylvania | — |
| Completed | Implantology and Sjögren's Syndrome NCT02661243 | Derk Jan Jager | N/A |
| Recruiting | Characterization of Diseases With Salivary Gland Involvement NCT02327884 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Aerobic Exercise in Primary Sjögren's Syndrome NCT02370225 | Samira Tatiyama Miyamoto, PhD | N/A |
| Unknown | Cyclosporine A in the TReatment of Interstitial Pneumonitis Associated With Sjogren's Syndrome NCT02370550 | Peking University People's Hospital | Phase 4 |
| Completed | Effect of Debridement-scaling on the Relief of Dry Eye Signs and Symptoms in Sjogren's Syndrome NCT02203188 | University of Waterloo | N/A |
| Withdrawn | Examining the Immunological Process of Autoimmune Patients NCT02123147 | University of Florida | — |
| Terminated | Effects of Sustained Reading on the Ocular Surface NCT02031172 | University of Rochester | — |
| Completed | Prospective Maternal Surveillance of SSA (Sjögren Syndrome A) Positive Pregnancies Using a Hand-held Fetal Hea NCT02920346 | University of Colorado, Denver | — |
| Completed | Omalizumab for Lupus NCT01716312 | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Phase 1 |
| Completed | At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurolo NCT01931644 | Sanguine Biosciences | — |
| Completed | Quality of Life and Sjögren Syndrome NCT03578900 | Grupo de Investigação em Bioquímica e Biologia Oral | Phase 4 |
| Unknown | Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments NCT01642706 | University Hospital, Montpellier | — |
| Recruiting | The Pathogenesis and Natural History of Sjogren's Disease NCT01425892 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Hydroxychloroquine Treatment of Dry Eyes in Patients With Primary Sjögren's Syndrome NCT01601028 | Seoul National University Hospital | Phase 3 |
| Withdrawn | Pulmozyme for Sjogren's Associated Cough NCT01357447 | UConn Health | Phase 1 |
| Completed | Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye NCT01393132 | Michigan Cornea Consultants, PC | Phase 2 |
| Completed | An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness NCT01369589 | Parion Sciences | Phase 1 / Phase 2 |
| Completed | The Research Registry for Neonatal Lupus NCT00074373 | NYU Langone Health | — |
| Completed | Evaluation of FID 114657 in Sjogren's Syndrome Subjects NCT01079871 | Alcon Research | N/A |
| Unknown | Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS) NCT00953485 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 1 / Phase 2 |
| Completed | Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome NCT00637793 | TorreyPines Therapeutics | Phase 2 |
| Completed | Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Interve NCT00631358 | Alcon Research | Phase 4 |
| Completed | Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome NCT00565526 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease NCT00809003 | University of Waterloo | — |
| Completed | Duke Autoimmunity in Pregnancy Registry NCT00513591 | Duke University | — |
| Completed | Rituximab Treatment in Sjogren's Syndrome NCT00363350 | University Medical Center Groningen | Phase 1 / Phase 2 |
| Terminated | Pilot Study of Raptiva to Treat Sjogren's Syndrome NCT00344448 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Completed | Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome NCT00233363 | Otsuka Pharmaceutical Co., Ltd. | Phase 2 |
| Completed | Anti-CD20 Antibody Therapy for Sjogren's Syndrome NCT00101829 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth NCT00750828 | Hacettepe University | — |
| Unknown | Sex Steroids in Sjögren's Syndrome: Effect of Substitution Treatment on Fatigue NCT00543166 | University of Helsinki | Phase 4 |
| Completed | Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek Cells NCT00023491 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome NCT00025818 | Allergan | Phase 3 |
| Completed | Dehydroepiandrosterone Administration in Women With Systemic Lupus Erythematosus or Primary Sjögren's Syndrome NCT00391924 | UMC Utrecht | Phase 2 |
| Completed | Etanercept Therapy for Sjogren's Syndrome NCT00001954 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Completed | The Functioning of Immune and Hormonal Systems in Patients With Sjogren's Syndrome and in Healthy Volunteers NCT00001953 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome NCT00001852 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops NCT00001731 | National Eye Institute (NEI) | Phase 2 |
| Completed | Pilot Study of Thalidomide to Treat Sjogren's Syndrome NCT00001599 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Completed | DHEA Treatment for Sjogren's Syndrome NCT00001598 | National Institute of Dental and Craniofacial Research (NIDCR) | Phase 2 |
| Terminated | Evaluation of Salivary Gland Dysfunction NCT00001196 | National Institute of Dental and Craniofacial Research (NIDCR) | — |