Trials / Active Not Recruiting
Active Not RecruitingNCT06324968
Ro60 Expression in Macrophages in Sjogren's Disease
Ro60 Expression in Macrophages in Patients with Primary Sjogren's Syndrome
- Status
- Active Not Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- Sponsor
- Centre Hospitalier Universitaire de Nice · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
Context: The Ro60 protein associates with YRNAs (or RNYs) to form the RoRNP complex, which regulates RNA surveillance and maturation. It is hypothesized that its impairment by nuclear penetration of the anti-Ro60 autoantibodies, would deregulate the anti-inflammatory response in monocytes/macrophages (Mo/Mp) in patients with Sjögren's disease (SD).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Positive serology for anti-SSA | Blood sample which detect serology for anti-SSA. |
Timeline
- Start date
- 2024-02-09
- Primary completion
- 2024-12-13
- Completion
- 2025-05-09
- First posted
- 2024-03-22
- Last updated
- 2025-03-11
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT06324968. Inclusion in this directory is not an endorsement.