NCT04909112

Olfactory and Taste Disturbances in Sjogren's Syndrome

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Université de Reims Champagne-Ardenne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Sjögren syndrome is an autoimmune disease, responsible for xerostomia and xerophthalmia. Other organs and tissues can be affected: the skin, vaginal and nasal mucous membranes. As well, olfactory disorders have been also described in Sjögren syndrome. Xerostomia often causes significant functional impairment of taste function. Impairment of taste function has been poorly evaluated in Sjögren syndrome like olfactory or (intra-nasal and oral) trigeminal disorders.

Detailed description

The aim of the study is to evaluate olfactory, taste (intra-nasal and oral) trigeminal functions in patients with Sjogren's syndrome compared to patients without sicca syndrome.

Conditions

• Sjogren's Syndrome

Interventions

Type	Name	Description
OTHER	Evaluation of olfactory function	Evaluation of olfactory function using olfactory detection thresholds
OTHER	Evaluation of taste function	Evaluation of taste function using taste detection thresholds
OTHER	Evaluation of (intra-nasal and oral) trigeminal functions	Evaluation of (intra-nasal and oral) trigeminal, interacting with olfactory and taste pathways, using odor and taste stimuli.

Timeline

• Start date: 2022-07-01
• Primary completion: 2022-07-01
• Completion: 2022-10-01
• First posted: 2021-06-01
• Last updated: 2022-05-25

Locations

1 site across 1 country: France