Trials / Unknown
UnknownNCT04749875
Study of Leukocyte Populations in Patients With Chronic Inflammatory
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,500 (estimated)
- Sponsor
- Assistance Publique - Hôpitaux de Paris · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare systemic autoimmune diseases with the objective of identifying therapeutic targets.
Detailed description
The primary objective is to characterization of the quantitative and qualitative specificities of the different leukocyte sub-populations in patients with chronic inflammatory rheumatism and rare systemic autoimmune diseases. We will perform an exploratory descriptive study whom primary endpoint will be to assess by FACS the phenotype of the specific leukocyte subsets. In addition, we will characterize the protein and transcriptomic signature associated with the conditions for which we have obtained preliminary data showing their potential involvement in autoimmunity (i.e: IL7 pathway, IFN signature).
Conditions
- Systemic Autoimmune Disease
- Chronic Inflammatory Rheumatism
- Sjogren's Syndrome
- Spondyloarthritis
- Rheumatoid Arthritis
- Systemic Lupus Erythematosus
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | blood sample | sampling of blood for research during routine care |
Timeline
- Start date
- 2021-03-01
- Primary completion
- 2026-03-01
- Completion
- 2026-03-01
- First posted
- 2021-02-11
- Last updated
- 2021-02-11
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04749875. Inclusion in this directory is not an endorsement.