Trials / Active Not Recruiting
Active Not RecruitingNCT04462601
Descriptive Study of Variations in Serum Translocation Markers of the Intestinal Microbiota in Patients With Gougerot-Sjögren Syndrome According to Disease Activity
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 50 (estimated)
- Sponsor
- Centre Hospitalier Universitaire de Nīmes · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Gougerot-Sjögren syndrome or Sjögren syndrome is a chronic autoimmune disease belonging to connectivitis, the classic triad of symptoms being the association of a sicca syndrome (generally predominant in the mouth and / or ocular, but also present at the cutaneous, vaginal or tracheal level), diffuse arthromyalgia and marked fatigue. The study investigators hypothesize that changes in the gut microbiota, by modulating gut permeability and thereby promoting microbial translocation, would have immunomodulatory effects that could be correlated to changes in the activity of Gougerot-Sjögren disease.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Biomarker detection | Quantification of serum markers of intestinal permeability and bacterial and fungal translocation |
Timeline
- Start date
- 2020-11-13
- Primary completion
- 2028-10-01
- Completion
- 2028-10-01
- First posted
- 2020-07-08
- Last updated
- 2025-11-17
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT04462601. Inclusion in this directory is not an endorsement.