NCT04239521

The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata

The Epidemiology, Management, and the Associated Burden of Mental Health, Atopic and Autoimmune Conditions, and Common Infections in Alopecia Areata

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 51,955 (actual)
• Sponsor: Momentum Data · Industry
• Sex: All
• Age: —
• Healthy volunteers: —

Summary

This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and incidence of psychiatric co-morbidities in people with alopecia areata, (3) the prevalence and incidence of autoimmune and atopic conditions in people with alopecia areata, and (4) the incidence of common infections in people with alopecia areata.

Detailed description

The overall purpose of the first study (Study 1) is to describe the epidemiology of Alopecia areata (AA) and to assess the current level of primary care service utilisation and management patterns associated with patients diagnosed with AA. The overall purpose of the second study (study 2) is to assess the prevalence and incidence of mental health conditions (depressive episodes, recurrent depressive disorder and anxiety disorder) in adult patients diagnosed with AA relative to a control population of patients without a diagnosis of AA. In addition, the study will determine both the treatment, 'sick day' and unemployment burden. Treatment burden comprises that of medications and psychological interventions used to treat mental health conditions in adult patients diagnosed with Alopecia areata. The overall purpose of the third study (Study 3) is to assess the prevalence and incidence of atopic and autoimmune conditions in adult patients diagnosed with AA relative to a control population of patients without AA. The overall purpose of the fourth study (Study 4) is to assess the incidence of common infections in adult patients diagnosed with AA relative to a control population of patients without AA.

Conditions

• Alopecia Areata
• Depressive Episode
• Recurrent Depressive Disorder
• Anxiety Disorders
• Atopic Dermatitis
• Allergic Rhinitis
• Asthma
• Crohn Disease
• Ulcerative Colitis
• Pernicious Anemia
• Type 1 Diabetes
• Hashimoto Thyroiditis
• Graves Disease
• Rheumatoid Arthritis
• Psoriatic Arthritis
• Ankylosing Spondylitis
• Systemic Lupus Erythematosus
• Polymyalgia Rheumatica
• Sjogren's Syndrome
• Psoriasis
• Vitiligo
• Multiple Sclerosis
• Celiac Disease
• Upper Respiratory Tract Infection
• Influenza
• Lower Resp Tract Infection
• Acute Bronchitis
• Pneumonia
• Gastrointestinal Infection
• Skin Infection
• Urinary Tract Infections
• Genital Infection
• Herpes Zoster
• Herpes Simplex
• Infection
• Infection Viral

Interventions

Type	Name	Description
OTHER	Exposure of interest (studies 2 & 3).	Common mental health conditions consist of depressive episodes, recurrent depressive disorder and anxiety disorder Atopic conditions consist of Atopic dermatitis, allergic rhinitis, asthma Autoimmune conditions consist of Crohn's disease, ulcerative colitis, Coeliac disease, Pernicious anaemia, Type 1 diabetes, Hashimoto's thyroiditis, Grave's disease, Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Systemic lupus erythematosus, polymyalgia rheumatica, Sjögren's syndrome, Psoriasis, vitiligo, Multiple sclerosis

Timeline

• Start date: 2020-10-01
• Primary completion: 2022-03-31
• Completion: 2022-11-28
• First posted: 2020-01-27
• Last updated: 2022-12-15

Locations

1 site across 1 country: United Kingdom