| Recruiting | Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL NCT06134492 | Jena University Hospital | Phase 3 |
| Completed | A Study on the Reactogenicity, Safety and Immune Response of a Targeted Immunotherapy Against HSV in Healthy J NCT05989672 | GlaxoSmithKline | Phase 1 |
| Completed | Neonatal Phase 1 Valacyclovir Study NCT05468619 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV i NCT05298254 | GlaxoSmithKline | Phase 1 / Phase 2 |
| Terminated | A Study on the Reactogenicity, Safety and Immune Response of a Vaccine Against Herpes Simplex Virus (HSV)-2 in NCT04762511 | GlaxoSmithKline | Phase 1 |
| Completed | The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata NCT04239521 | Momentum Data | — |
| Recruiting | Randomized, Placebo-controlled, Double-blind Study of 2LHERP® in Orofacial Herpes Infections. NCT04065971 | Labo'Life | Phase 4 |
| Completed | Study of the Efficacy and Safety of Combined Treatment of Patients With Severe Herpes Simplex (HSV) Infection NCT04664127 | Nearmedic Plus LLC | — |
| Unknown | Tzanck Smear With Methylene Blue Stain for Herpes NCT03178747 | Chulalongkorn University | Phase 3 |
| Completed | Feasibility and Effects of Valaciclovir Treatment in Persons With Early Alzheimer's Disease NCT02997982 | Hugo Lovheim | Phase 2 |
| Completed | Clinical Evaluation of the Sentosa SA HSV1/2 Qualitative PCR Test NCT02685956 | Vela Diagnostics | — |
| Withdrawn | Antiviral Prophylaxis in a Burn Population NCT02349828 | Southern Illinois University | Phase 2 / Phase 3 |
| Completed | Open-label Study of ASP2151 in Herpes Simplex Patients NCT02209324 | Maruho Co., Ltd. | Phase 3 |
| Completed | Phase III Study of ASP2151 in Herpes Simplex Patients NCT01959295 | Maruho Co., Ltd. | Phase 3 |
| Completed | Valacyclovir Augmentation for Cognitive and Functional Remediation in Schizophrenia NCT01794897 | University of Pittsburgh | Phase 4 |
| Completed | Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients NCT01602562 | GlaxoSmithKline | Phase 3 |
| Completed | Can Valacyclovir Attenuate Inflammation in Antiretroviral-Treated HIV-Infected Individuals With Herpes Simplex NCT01176409 | University Health Network, Toronto | Phase 3 |
| Completed | Effectiveness of TheraNeem Lip Therapy for Herpes Simplex Labialis NCT00985335 | Southern California University of Health Sciences | Phase 1 |
| Completed | Prevalence of Sexually Transmitted Infections (STIs) in HIV-infected Patients NCT00973466 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Acyclovir in Preventing Herpes Simplex Virus Infection in Patients With Neutropenia NCT00855309 | Wake Forest University Health Sciences | Phase 3 |
| Completed | HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding NCT00530777 | University of Washington | Phase 2 |
| Completed | Activation of Alternative Cellular Energy (ACE) Pathway in the Therapy of Herpes Virus Infections NCT00642785 | Institute of Progressive Medicine | — |
| Completed | Pharmacokinetics, Acceptability and Safety of Famciclovir in Infants (1 Month to Less Than 12 Months) With Her NCT00448227 | Novartis | Phase 2 |
| Unknown | 30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers NCT00587496 | National Eye Institute (NEI) | Phase 1 |
| Terminated | Herpevac Neonatal Substudy NCT00138320 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Episodic Acyclovir Therapy for Genital Ulcers NCT00164424 | Centers for Disease Control and Prevention | Phase 2 / Phase 3 |
| Completed | Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex Infection NCT00098059 | Novartis Pharmaceuticals | Phase 3 |
| Completed | HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1 Co-infected Persons NCT00465205 | University of Washington | Phase 3 |
| Completed | Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Ol NCT00224484 | GlaxoSmithKline | Phase 3 |
| Terminated | A Study of HSV Testing Among Pregnant Women NCT00194415 | University of Washington | N/A |
| Completed | Study to Compare Safety and Immunogenicity of Commercial Scale Consistency Lots of Herpes Simplex Vaccine NCT00224471 | GlaxoSmithKline | Phase 3 |
| Completed | HSV-2 Suppression to Reduce HIV-1 Levels in HIV-1, HSV-2 Co-infected Men. NCT00378976 | University of Washington | Phase 3 |
| Completed | A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons NCT00161434 | University of Washington | Phase 4 |
| Completed | A Safety And Tolerability Study Of Valaciclovir Oral Suspension In Infants And Children NCT00297206 | GlaxoSmithKline | Phase 1 |
| Completed | Safety, Acceptability and Preliminary Effectiveness of PC-515 for Vaginal Use as a Possible Microbicide NCT00213031 | Population Council | Phase 2 |
| Completed | Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth NCT00031447 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Unknown | A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients NCT00005663 | Glaxo Wellcome | Phase 3 |
| Completed | Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates NCT00031460 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | Structure of the Herpes Simplex Virus Receptor NCT00001648 | National Institute of Allergy and Infectious Diseases (NIAID) | — |
| Completed | Valaciclovir to Prevent Transmission of Herpes Simplex Virus NCT00001649 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Unknown | Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Involving the Cent NCT00006132 | National Center for Research Resources (NCRR) | Phase 3 |
| Completed | Phase III Randomized Study of Oral Acyclovir in Infants With Herpes Simplex Virus Infection Limited to Skin, E NCT00006135 | National Center for Research Resources (NCRR) | Phase 3 |
| Completed | Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Diseas NCT00699764 | GlaxoSmithKline | Phase 3 |
| Completed | Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Vir NCT00004644 | National Center for Research Resources (NCRR) | Phase 1 / Phase 2 |
| Completed | Herpetic Eye Disease Study (HEDS) II NCT00000139 | National Eye Institute (NEI) | Phase 3 |
| Completed | Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus NCT00004757 | National Center for Research Resources (NCRR) | Phase 3 |
| Completed | Evaluation of Safety of Candidate gD Vaccine, With or Without MPL in Healthy Herpes Simplex Virus-positive Adu NCT00698893 | GlaxoSmithKline | Phase 1 |
| Completed | The Effect of Valacyclovir on the Detection of HIV From Genital Herpes Lesions in HIV-Infected Patients NCT00002404 | Glaxo Wellcome | N/A |
| Completed | Cidofovir as a Treatment for Herpes Simplex in Patients With AIDS NCT00002181 | Gilead Sciences | N/A |
| Completed | Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclo NCT00002186 | Shaman Pharmaceuticals | N/A |
| Completed | The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAU NCT00000654 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | A Study to Compare the Efficacy and Safety of Valacyclovir Hydrochloride ( 256U87 ) Versus Acyclovir in the Tr NCT00002000 | Glaxo Wellcome | N/A |
| Completed | An Open, Multicenter Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With NCT00002272 | Astra USA | N/A |
| Withdrawn | The Safety and Effectiveness of Valacyclovir HCl in the Treatment of Herpes Simplex or Varicella/Zoster Infect NCT00001054 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | SP-303T Applied to the Skin of Patients With Herpes Simplex Virus (HSV) Infection and AIDS Who Have Not Had Su NCT00002310 | Shaman Pharmaceuticals | N/A |
| Completed | Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have NCT00000985 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 3 |
| Completed | Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot NCT00000635 | National Institute of Allergy and Infectious Diseases (NIAID) | N/A |
| Completed | A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine D NCT00002116 | Gilead Sciences | Phase 1 |
| Completed | A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital H NCT00002084 | Glaxo Wellcome | N/A |
| Completed | The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the Blood NCT00001115 | National Institute of Allergy and Infectious Diseases (NIAID) | N/A |
| Completed | An Open Study of Foscarnet Treatment of Acyclovir-Resistant Herpes Simplex Virus in Patients With the Acquired NCT00002021 | Astra USA | N/A |
| Completed | The Pilot Study of Foscarnet Cream in the Treatment of Mucocutaneous Herpes Simplex Virus Infections in Immuno NCT00002144 | Astra USA | Phase 1 |