| Recruiting | Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total NCT07292298 | University of Colorado, Denver | Phase 2 |
| Not Yet Recruiting | Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-ris NCT07527520 | Fudan University | Phase 2 |
| Not Yet Recruiting | 1. SAFE-AI ONCO-TRACK: Multimodal GenAI for Early Detection of Minimal Residual Disease and Recurrence in Gast NCT07189520 | Università Politecnica delle Marche | — |
| Not Yet Recruiting | Clinical and BIOgical Analyses of RECtal Tumors NCT07499921 | Centre Leon Berard | N/A |
| Not Yet Recruiting | Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathologica NCT07404228 | Institut du Cancer de Montpellier - Val d'Aurelle | — |
| Not Yet Recruiting | Injection of IP-001 Into Thermally Ablated Hepatic Tumors in Patients With Colorectal Liver Metastases NCT07321847 | Immunophotonics, Inc. | Phase 2 / Phase 3 |
| Not Yet Recruiting | PET/MRI in Rectal Cancer NCT06057831 | AHS Cancer Control Alberta | Phase 2 |
| Not Yet Recruiting | Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecita NCT07509424 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 |
| Recruiting | Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer NCT07528209 | Sun Yat-sen University | Phase 3 |
| Recruiting | Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Res NCT07537998 | Pei-Rong Ding | Phase 2 / Phase 3 |
| Not Yet Recruiting | FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases NCT07467434 | Assistance Publique - Hôpitaux de Paris | — |
| Not Yet Recruiting | Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal NCT07341126 | University of Edinburgh | — |
| Recruiting | Registry Maastro Applicator NCT07501845 | Maastricht Radiation Oncology | — |
| Recruiting | The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal NCT07369531 | The First Hospital of Jilin University | N/A |
| Not Yet Recruiting | Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer NCT07483060 | Vastra Gotaland Region | Phase 4 |
| Not Yet Recruiting | A Phase II Prospective Study of Maastro Applicator Brachytherapy for Rectal Cancer NCT07402486 | Siriraj Hospital | Phase 2 |
| Not Yet Recruiting | Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer NCT06123156 | University Hospital, Rouen | Phase 3 |
| Not Yet Recruiting | Advanced Endoscopic Resections for Rectal Neoplasms NCT07410767 | Jagiellonian University | — |
| Not Yet Recruiting | ctDNA-Informed Management of Early-Stage Rectal Cancer NCT07209215 | University of California, Davis | Phase 2 |
| Recruiting | Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab W NCT07505472 | The First Hospital of Jilin University | Phase 2 / Phase 3 |
| Not Yet Recruiting | Effect of Individualized Catheter Management on Early Removal After Rectal Cancer Surgery NCT07346586 | The First Hospital of Jilin University | N/A |
| Not Yet Recruiting | A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined Wit NCT07113275 | Tao Zhang | Phase 3 |
| Not Yet Recruiting | Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS NCT07394192 | Peking University Cancer Hospital & Institute | Phase 2 |
| Not Yet Recruiting | Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer ( NCT07381400 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | Phase 2 |
| Recruiting | A Study on the Accurate Evaluation of Pseudoprogression of Rectal Cancer Immunotherapy Based on Multitemporal NCT07381322 | Peiyi Xie | — |
| Recruiting | Organ Preservation in Rectal Cancer by Dose Escalated MR Guided Adaptive Radiotherapy NCT07337876 | University Hospital Tuebingen | Phase 2 |
| Not Yet Recruiting | A Pilot Study Evaluating β-hydroxybutyrate Supplementation Concomitant to Short-Course Radiotherapy Followed b NCT07239466 | Tao Zhang | Phase 2 |
| Not Yet Recruiting | A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Re NCT07248020 | Chang Gung Memorial Hospital | Phase 2 |
| Not Yet Recruiting | Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND) NCT07306390 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | — |
| Not Yet Recruiting | Autologous Probiotics in Patients With Defunctioning Ileostomy Following LAR for Rectal Cancer NCT07366047 | Peking University Cancer Hospital & Institute | N/A |
| Enrolling By Invitation | The SMART Trial: Modified Single-Stapled Anastomosis in Laparoscopic or Robotic Low Anterior Resection for Rec NCT07376980 | Korea University Anam Hospital | N/A |
| Not Yet Recruiting | SIB-RT Combined With CAPOX and PD-1 for High-Risk Rectal Cancer NCT07297030 | Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress NCT07253298 | National Taiwan University Hospital | N/A |
| Recruiting | Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior NCT07098182 | Institut du Cancer de Montpellier - Val d'Aurelle | N/A |
| Recruiting | A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy NCT07227636 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Withdrawn | A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Re NCT07223567 | M.D. Anderson Cancer Center | Phase 2 |
| Recruiting | The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function NCT07369830 | Huashan Hospital | N/A |
| Recruiting | Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer NCT07068763 | Sir Run Run Shaw Hospital | Phase 2 |
| Not Yet Recruiting | Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced R NCT07134218 | Changhai Hospital | Phase 2 / Phase 3 |
| Not Yet Recruiting | ESD in Locally Advanced Rectal Cancer Following CRT NCT07192627 | Assiut University | — |
| Recruiting | Response-adapted Total Neoadjuvant Therapy Guided by Induction Chemotherapy in Early- and Intermediate-risk Lo NCT07260526 | West China Hospital | — |
| Not Yet Recruiting | ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer NCT07188025 | Erasmus Medical Center | Phase 3 |
| Not Yet Recruiting | Magnetic Resonance Imaging (MRI)-Guided Rectal Cancer Preservation Program NCT07134296 | Clinica Universidad de Navarra, Universidad de Navarra | N/A |
| Recruiting | A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Canc NCT07011576 | SCRI Development Innovations, LLC | Phase 2 |
| Not Yet Recruiting | Walking and Sitting Difficulties After Rectal Cancer Surgery NCT07035600 | Sahlgrenska University Hospital | N/A |
| Recruiting | SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC NCT07284992 | Shandong Provincial Hospital | Phase 2 |
| Recruiting | CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors NCT07179692 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Recruiting | SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Lea NCT07209787 | Beijing Chao Yang Hospital | Phase 4 |
| Recruiting | SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC NCT07198165 | Ruijin Hospital | Phase 2 |
| Not Yet Recruiting | SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer NCT07162714 | Zhejiang Cancer Hospital | Phase 2 |
| Not Yet Recruiting | Low Powered Colorectal Anastomosis After Rectal Excision (OASIS) NCT07146334 | Bordeaux Colorectal Institute | — |
| Not Yet Recruiting | Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensifie NCT06936774 | University Hospital, Basel, Switzerland | Phase 3 |
| Recruiting | Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Toripalimab, Liposomal Irinotecan, NCT07104604 | Affiliated Cancer Hospital of Shantou University Medical College | Phase 1 |
| Not Yet Recruiting | Neoadjuvant Chemoradiotherapy Followed by Chemotherapy With or Without Tislelizumab for Resectable Ultra-low R NCT07132463 | Fudan University | Phase 3 |
| Not Yet Recruiting | the Efficacy of MR-guided Online Adaptive Radiotherapy for Locally Advanced Rectal Cancer NCT07080411 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Not Yet Recruiting | Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-cente NCT06850090 | Shandong Cancer Hospital and Institute | Phase 3 |
| Recruiting | Sample Collection for Ongoing Research and Product Evaluation Study NCT07318051 | Natera, Inc. | — |
| Withdrawn | Neoadjuvant Chemoradiotherapy Plus Sintilimab for MSS, Locally Advanced Rectal Cancer- NCT06895577 | Sun Yat-sen University | Phase 2 |
| Recruiting | Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoad NCT07108127 | Peking Union Medical College Hospital | Phase 2 |
| Recruiting | Leucine Plus Radiochemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cancer NCT07359989 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Not Yet Recruiting | Preservation Vs. Dissection of No. 253 Lymph Nodes of Robotic Resection for Mid/Low Rectal Cancer NCT06956976 | Fudan University | N/A |
| Recruiting | A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With S NCT06682793 | A2 Biotherapeutics Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer NCT06931873 | Changhai Hospital | EARLY_Phase 1 |
| Recruiting | Node-Sparing Short-Course Radiotherapy Sequential Chemotherapy and PD-1 Inhibitor for Mid/Low pMMR/MSS Rectal NCT06958432 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 / Phase 3 |
| Not Yet Recruiting | Safety and Efficacy Study of Single-port Robotic Versus Multi-port Robotic Radical Rectal Cancer Surgery NCT06943690 | Ruijin Hospital | N/A |
| Recruiting | Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable) NCT06914245 | KU Leuven | N/A |
| Recruiting | Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women NCT06904365 | Washington University School of Medicine | — |
| Not Yet Recruiting | Short-course Radiation (SCRT) Followed by 6 Cycles of Cadonilimab Plus MFOLFOX6 As Neoadjuvant Therapy for Pat NCT06832917 | Wan He | Phase 3 |
| Recruiting | Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low L NCT06923345 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | External Beam Radiotherapy Combined with Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients NCT06729645 | University Hospital of Cologne | N/A |
| Recruiting | Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions NCT07056374 | Amsterdam UMC, location VUmc | — |
| Recruiting | Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant The NCT06884670 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Recruiting | Brodalumab in the Treatment of Immune-Related Adverse Events NCT06673329 | Brian Henick, MD | Phase 1 |
| Recruiting | Contact Radiotherapy for Rectal Cancer NCT06501053 | Alexander Valdman | N/A |
| Recruiting | Neoadjuvant Short-Course Radiotherapy With or Without Chemotherapy and AK112 in Locally Advanced Rectal Cancer NCT06718543 | fan li | Phase 2 |
| Recruiting | Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer. NCT06758830 | National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos | Phase 2 / Phase 3 |
| Not Yet Recruiting | A Prospective Study of Expression Profiling-based Assessment of the Efficacy of Neoadjuvant Therapy for Rectal NCT06746298 | Shanghai Minimally Invasive Surgery Center | — |
| Not Yet Recruiting | Multi-Technology Integrated Total Mesorectal Excision Versus Conventional Total Mesorectal Excision for the Tr NCT06613399 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Not Yet Recruiting | Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Pa NCT05807646 | Sichuan Cancer Hospital and Research Institute | N/A |
| Recruiting | The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Underg NCT06565052 | Dana-Farber Cancer Institute | N/A |
| Active Not Recruiting | A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in C NCT06710847 | GlaxoSmithKline | Phase 1 / Phase 2 |
| Recruiting | Implementation of a Tumor Response Assessment Program Integrating the Shared Medical Decision Into the Organ P NCT06740357 | Centre Hospitalier Universitaire Dijon | N/A |
| Recruiting | EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With NCT06263088 | Case Comprehensive Cancer Center | N/A |
| Completed | A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant C NCT06608537 | Sun Yat-sen University | Phase 2 |
| Recruiting | Total Neoadjuvant Treatment of Rectal Cancer by MRI-guided Radiotherapy NCT05916040 | Universitair Ziekenhuis Brussel | — |
| Completed | Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients NCT06698289 | Mersin University | — |
| Recruiting | Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome. NCT06628674 | Chang Gung Memorial Hospital | N/A |
| Not Yet Recruiting | CGA Guided Ultrafractionated RT and First-line Systemic Treatment in Elderly or Frail Patients with MCRC NCT06665087 | Fudan University | Phase 2 |
| Active Not Recruiting | the Effect of Environmental Factors on Colorectal Cancer Based on Macrogenomes NCT06852495 | Dong Peng | — |
| Recruiting | Planed Organ Preservation for Low Rectal Cancer After Neoadjuvant Chemotherapy (OPLAR) NCT07070622 | West China Hospital | Phase 3 |
| Not Yet Recruiting | CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized NCT06652412 | Fudan University | Phase 2 |
| Completed | PeLear CCC: Proyecto Latino Contra Cancer Colorrectal NCT06426927 | University of North Carolina, Chapel Hill | N/A |
| Recruiting | Asian Watch-and-Wait Database (AWWD) NCT06631443 | Tata Memorial Centre | — |
| Recruiting | Application of Amide Proton Transfer-Weighted Imaging in Predicting Pathological Complete Response After Neoad NCT06719414 | Sixth Affiliated Hospital, Sun Yat-sen University | — |
| Recruiting | Virtual Ileostomy Versus Diverting Ileostomy in Patients Undergoing Total Mesorectal Excision NCT06633133 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Recruiting | A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer NCT06637462 | Memorial Sloan Kettering Cancer Center | N/A |
| Recruiting | A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy With IL-2 Followed by Sequential Im NCT06577194 | The First Affiliated Hospital with Nanjing Medical University | Phase 2 |
| Not Yet Recruiting | Study of the Predictive and Prognostic Role of Pharmacogenetic and Radiogenic Variants on the Response to Neoa NCT06616870 | Centro di Riferimento Oncologico - Aviano | — |
| Not Yet Recruiting | Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer NCT06097416 | St. James's Hospital, Ireland | Phase 3 |
| Not Yet Recruiting | Neoadjuvant Moderately Hypofractionated Radiotherapy Combined with Chemotherapy and Immunotherapy for High-ris NCT06599827 | Shanghai Zhongshan Hospital | Phase 2 |
| Recruiting | Hyperthermia With Chemoradiotherapy in Rectal Cancer NCT06831981 | University Hospital Tuebingen | N/A |
| Recruiting | Pre-therapeutic MRI Assessment of Early-Stage Rectal Cancer and Significant Rectal Polyps to Avoid Major Resec NCT04103372 | Imperial College London | N/A |
| Recruiting | Selective Defunctioning Stoma in Low Anterior Resection for Rectal Cancer NCT06214988 | Skane University Hospital | N/A |
| Active Not Recruiting | Feasibility of the Maastro Applicator in Rectal Cancer NCT06087718 | Maastricht Radiation Oncology | N/A |
| Not Yet Recruiting | Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Tria NCT06524362 | GEM Hospital & Research Center | N/A |
| Recruiting | Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUC NCT06770270 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Not Yet Recruiting | Effects of Exosome Adminstration in Preventing Early Leakage in Rectal Cancer Patients Undergoing Low Anterior NCT06536712 | Tehran University of Medical Sciences | Phase 1 |
| Completed | Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision NCT06505863 | Cantonal Hospital of St. Gallen | — |
| Recruiting | Watch and Wait Management on Rectal Cancer Patients Using New Swift Local Therapy NCT04336202 | Sir Mortimer B. Davis - Jewish General Hospital | N/A |
| Recruiting | Node-sparing Short-Course Radiation Combined With CAPOX and Tislelizumab for MSS Rectal Cancer NCT06507371 | Sir Run Run Shaw Hospital | Phase 3 |
| Recruiting | Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARC NCT06542588 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 |
| Recruiting | Prospective Monocentric Study Evaluating the Circulating NK Cells Phenotype and the ImmunoScore® in Patients W NCT06536127 | Institut Sainte Catherine | N/A |
| Not Yet Recruiting | Application of PD-1 Monoclonal Antibody in Combination With IL-2 and CapeOX in Organ Preservation Therapy for NCT06504875 | The First Affiliated Hospital with Nanjing Medical University | — |
| Not Yet Recruiting | Taking a Look at Patient Experiences In Rectal Cancer Clinical Trials NCT05910099 | Power Life Sciences Inc. | — |
| Recruiting | Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer NCT06205485 | Canadian Cancer Trials Group | Phase 3 |
| Recruiting | A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo NCT06923150 | Qufora A/S | — |
| Recruiting | Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors NCT06239194 | ModeX Therapeutics, An OPKO Health Company | Phase 1 / Phase 2 |
| Recruiting | Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic Cancers NCT05938322 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Not Yet Recruiting | Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally A NCT06443671 | Peking University Cancer Hospital & Institute | Phase 2 / Phase 3 |
| Enrolling By Invitation | The Effect of Minimally Invasive Surgery on Systemic Inflammatory Response in Rectal Cancer NCT06540027 | Başakşehir Çam & Sakura City Hospital | — |
| Recruiting | ctDNA Monitoring to Predict the Efficacy of TNT for Rectal Cancer NCT06589388 | Gene Solutions | — |
| Recruiting | Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal NCT06328361 | Tampere University Hospital | N/A |
| Recruiting | Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant Treatment NCT05927584 | Fundación de Investigación Biomédica - Hospital Universitario de La Princesa | — |
| Not Yet Recruiting | Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors NCT04889742 | Charite University, Berlin, Germany | Phase 2 |
| Recruiting | Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rec NCT06455124 | Fudan University | Phase 2 |
| Active Not Recruiting | A Clinical Trial Comparing Staged Turnbull-Cutait Pull-through Anastomosis With Direct Anastomosis Plus Prophy NCT06662643 | Zhongnan Hospital | N/A |
| Recruiting | Stigma and Psychological profilE in REctal-anal caNcer pAtients NCT06366841 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | Study of Fruquintinib Combined With Tegafur Gimeracil Oteracil in Patients With Metastatic Colorectal Cancer NCT06255379 | Guangzhou University of Traditional Chinese Medicine | Phase 2 |
| Unknown | Multimodal Imaging in Rectal Cancer & Pancreatic Cancer NCT06395337 | Radboud University Medical Center | Phase 1 / Phase 2 |
| Not Yet Recruiting | Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE NCT06390982 | Fudan University | Phase 2 |
| Recruiting | Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary NCT06274190 | KU Leuven | N/A |
| Completed | Comprehensive Management of Rectal Cancer NCT06839508 | Centre Hospitalier de Saint-Denis | — |
| Not Yet Recruiting | A Randomized Controlled Trial of the Safety and Efficacy of Robotic Telesurgery Versus Laparoscopic Surgery NCT06369597 | Sun Yat-sen University | N/A |
| Recruiting | High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial) NCT06337552 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Recruiting | A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With So NCT06051695 | A2 Biotherapeutics Inc. | Phase 1 / Phase 2 |
| Recruiting | Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome) NCT06519006 | F. D. Roosevelt University Hospital | N/A |
| Recruiting | Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients NCT06314646 | Istituto Clinico Humanitas | — |
| Withdrawn | Effect of ICCAUT Strategy on Postoperative Urinary Retention After Radical Rectal Cancer Surgery (ICCAUT-2) NCT06217016 | The First Hospital of Jilin University | N/A |
| Completed | Effect of ICCAUT Strategy on Postoperative Urinary Dysfunction After Radical Rectal Cancer Surgery NCT06241703 | The First Hospital of Jilin University | N/A |
| Not Yet Recruiting | Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab NCT06304545 | Harbin Medical University | Phase 2 |
| Unknown | Phase 1 Study of UCMYM802 Injection in Mesothelin-positive Advanced Malignant Solid Tumors NCT06256055 | UTC Therapeutics Inc. | Phase 1 |
| Unknown | Genotype-driven Weekly Irinotecan Liposomes in Combination With Capecitabine-based Neoadjuvant Chemoradiation NCT06300489 | Zhejiang Cancer Hospital | Phase 1 |
| Recruiting | The Effects of Neoadjuvant Tislelizumab Combined With Chemotherapy in Locally Advanced MSS Rectal Cancer NCT06254521 | First Affiliated Hospital of Guangxi Medical University | Phase 2 |
| Recruiting | Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cance NCT06210971 | Hebei Medical University Fourth Hospital | Phase 2 |
| Recruiting | Organ Preservation First Strategy and Intentional Watch and Wait for MRI Defined Low-risk Rectal Cancer NCT06209099 | Peking University Cancer Hospital & Institute | N/A |
| Recruiting | Lumeneye Rectoscope for Assessment on Tumor Response After Total Neoadjuvant Treatment in Rectal Cancer NCT06189846 | Bordeaux Colorectal Institute Academy | — |
| Recruiting | Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy NCT05965531 | Sun Yat-sen University | Phase 2 |
| Unknown | PET/MR Evaluation of Regression Grading After Neoadjuvant Therapy for Rectal Cancer NCT06318234 | Xiao Chen | — |
| Recruiting | Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy NCT06765616 | Feng Tian | Phase 2 |
| Completed | A Prediction Model of Anastomotic Stricture After Rectal Cancer NCT06404554 | Northern Jiangsu People's Hospital | — |
| Withdrawn | Circulating Tumor DNA to Monitor the Efficacy of Total Neoadjuvant Therapy for Rectal Cancer NCT05356585 | Case Comprehensive Cancer Center | — |
| Recruiting | The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection NCT06222255 | Seoul National University Hospital | N/A |
| Recruiting | Safety of Mid and Low Rectal Cancer Surgery Without Dissection of the No.253 Lymph Node (S-M-O-O-T-H) NCT06146946 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | N/A |
| Recruiting | Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Adva NCT06246344 | Shandong Cancer Hospital and Institute | — |
| Unknown | Defunctioning Left-sided Colostomy in Low Anterior Resection for Rectal Cancer NCT06149741 | Umeå University | N/A |
| Completed | Changes of Low Anterior Resection Syndrome and Balance Ability in Patients With Rectal Cancer. NCT06006260 | Chang Gung Memorial Hospital | — |
| Recruiting | Total Neoadjuvant Therapy in Rectal Cancer NCT06162650 | National Cheng-Kung University Hospital | Phase 2 |
| Not Yet Recruiting | Treatment of Low Locally Advanced Rectal Cancer With Radiotherapy Removal TNT Plus Neoadjuvant Therapy NCT06035133 | Tang-Du Hospital | N/A |
| Recruiting | Clinical Study of CEA Targeting Chimeric Antigen Receptor T Lymphocytes（CAR-T） for CEA Positive Advanced Malig NCT06126406 | Chongqing Precision Biotech Co., Ltd | Phase 1 |
| Not Yet Recruiting | Hepatopulmonary Radio-sterilization With Immunotherapy NCT06053996 | Sheba Medical Center | N/A |
| Withdrawn | Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer NCT04620473 | Shanghai Minimally Invasive Surgery Center | Phase 2 |
| Completed | Robotic Natural Orifice Specimen Extraction Surgery Versus Robotic Transabdominal Specimen Extraction Surgery NCT06405308 | Taiyuan Li | — |
| Recruiting | An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer NCT05914766 | Massachusetts General Hospital | N/A |
| Recruiting | Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Local NCT06380101 | University of South Florida | N/A |
| Recruiting | CEA Targeting Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of CEA Positive Advanced Solid NCT06006390 | Chongqing Precision Biotech Co., Ltd | Phase 1 / Phase 2 |
| Recruiting | Salvage Chemotherapy Versus Total Mesorectal Resection for Local Resection Rectal Cancer Patients NCT06043999 | Sun Yat-sen University | N/A |
| Recruiting | Efficacy and Toxicity of Total Neoadjuvant Sandwich Treatment Via Short Course Radiotherapy in the Treatment o NCT07095439 | Ain Shams University | Phase 2 |
| Recruiting | Factors Affecting the Results of Treatment of Patients With Colorectal Cancer NCT06050447 | Immanuel Kant Baltic Federal University | — |
| Not Yet Recruiting | Short-course Radiotherapy Combined With Furoquintinib and PD-1 Monoclonal Antibody NCT06014944 | Changhai Hospital | Phase 2 |
| Unknown | Quality of Life and Psychosocial Status of Young-onset Patients With Rectal Cancer NCT06216834 | Shandong Provincial Hospital | — |
| Recruiting | Neoadjuvant CIETAI With Concurrent Chemoradiotherapy in Local Advanced Rectal Cancer NCT05957016 | Third Military Medical University | Phase 2 |
| Not Yet Recruiting | Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal NCT05969847 | 池畔 | Phase 2 |
| Unknown | Online Adaptive Radiation Therapy for Rectal Cancer NCT05911789 | Peking Union Medical College Hospital | Phase 1 / Phase 2 |
| Recruiting | Natural Orifice Specimen Extraction in Low Rectal Cancer Surgery NCT06326892 | Istituto Clinico Humanitas | — |
| Recruiting | Toripalimab Combined With Neoadjuvant Chemoradiotherapy as First-line Treatment for Locally Advanced，High-Risk NCT05877573 | Nanfang Hospital, Southern Medical University | N/A |
| Recruiting | Total Neoadjuvant Treatment Combined With Adaptive Radiotherapy for Rectal Cancer NCT05883800 | Haukeland University Hospital | N/A |
| Unknown | 68Ga-FAPI-04 PET Imaging in Early Response Evaluation of Rectal Cancer Patients Treated With Immunotherapy NCT05999227 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | N/A |
| Recruiting | Prophylactic Mesh Placement During Stoma Closure After Low Anterior Resection NCT05939687 | Blokhin's Russian Cancer Research Center | Phase 3 |
| Completed | Exploring the Predictive Effect of Intestinal and Oral Microbiota on the Efficacy of Neoadjuvant Radiotherapy NCT07346729 | Nanfang Hospital, Southern Medical University | — |
| Recruiting | A Multicenter Single-arm P2 to Evaluate Safety and Efficacy of the Total Neoadjuvant Therapy for cT2 Rectal Ca NCT05939661 | Osaka University | Phase 2 |
| Recruiting | The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard NCT05943210 | Weill Medical College of Cornell University | N/A |
| Unknown | Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal A NCT05772481 | Institut de cancérologie Strasbourg Europe | — |
| Recruiting | Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer NCT05806931 | Rutgers, The State University of New Jersey | Phase 2 |
| Recruiting | Reasons for Non-reversal of Temporary Stomas After Surgeries of Mid-low Rectal Cancer （NORESTO Study） NCT06194708 | Peking Union Medical College Hospital | — |
| Unknown | Total Neoadjuvant Therapy With Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Adva NCT05858567 | Sir Run Run Shaw Hospital | Phase 2 |
| Completed | MRI T1 Relaxation Time in Rectal Cancer NCT05876026 | Vejle Hospital | — |
| Recruiting | Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer NCT04339374 | Washington University School of Medicine | N/A |
| Not Yet Recruiting | Re-irradiation Therapy of Locally Recurrent Rectal Cancer With Carbon Ion NCT05807984 | Xin Cai | Phase 2 |
| Unknown | Prognostic Factors Affecting Recurrence and Disease-Free Survival After Surgical Resection for Cancer Rectum NCT06096493 | South Valley University | — |
| Not Yet Recruiting | The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard NCT05640726 | Fujian Cancer Hospital | Phase 2 |
| Recruiting | Quality Of Life In Colorectal Cancer Survivors NCT07427901 | Institute of Oncology Ljubljana | N/A |
| Completed | Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer NCT05943041 | GILongevity | Phase 1 |
| Withdrawn | GI Organ Tracking Via Balloon Applicators NCT05471401 | Washington University School of Medicine | N/A |
| Recruiting | Radical vs Local Excision for Rectal Cancer With Clinically Complete Remission NCT05964530 | National Taiwan University Hospital | N/A |
| Recruiting | Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenoc NCT05752136 | Sir Run Run Shaw Hospital | Phase 3 |
| Unknown | CRP-guided Transanal Drainage Removal After Rectal Surgery NCT05502354 | Qilu Hospital of Shandong University | N/A |
| Recruiting | CLASSICA: Validating AI in Classifying Cancer in Real-Time Surgery NCT05793554 | Mater Misericordiae University Hospital | — |
| Recruiting | Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi) NCT06229041 | Peking University Cancer Hospital & Institute | Phase 3 |
| Unknown | XELOX Combined With Cadonilimab Versus XELOX as Neoadjuvant Treatment for Locally Advanced, pMMR Rectal Cancer NCT05815303 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 2 |
| Recruiting | SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rec NCT05576480 | Ruijin Hospital | Phase 2 |
| Unknown | Video Analysis of Errors and Technical Performance Within Minimally Invasive Surgery Short Title: Video Analys NCT05279287 | The Griffin Institute | — |
| Unknown | Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy NCT05759741 | Huashan Hospital | EARLY_Phase 1 |
| Recruiting | Longterm Functional Outcomes in Patients Undergoing Organ Preserving Treatment for Rectal Cancer With or Witho NCT06249672 | Insel Gruppe AG, University Hospital Bern | — |
| Recruiting | Advanced Pelvic Surgical Oncology Database - Prospective Observational Study NCT05696002 | Glasgow Royal Infirmary | — |
| Unknown | PelvEx - Beating the Empty Pelvis Syndrome NCT05683795 | University of Southampton | — |
| Completed | Virtual Ileostomy Versus Diverting Ileostomy NCT05985239 | fan li | — |
| Unknown | Indocyanine Green-guided Lymphadenectomy in Laparoscopic Total Mesorectal Excision for Low Rectal Cancer After NCT05873621 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | N/A |
| Not Yet Recruiting | Effects of Different Treatment for Anorectal Function of Patients With Rectal Cancer NCT05671809 | Sixth Affiliated Hospital, Sun Yat-sen University | — |
| Not Yet Recruiting | ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer NCT05629442 | Massachusetts General Hospital | — |
| Not Yet Recruiting | The OPERa Study: Evaluating QoL After Rectal Cancer Surgery NCT04893876 | Jewish General Hospital | — |
| Unknown | Radioisotope and Fluorescence Guidance in Rectal Cancer NCT05336643 | University College, London | N/A |
| Unknown | Sarcopenia and Multimodal Rehabilitation on the Prognosis of Rectal Cancer Patients Receiving CCRT NCT05664607 | Chang Gung Memorial Hospital | N/A |
| Recruiting | A Study of Tucatinib and Trastuzumab in People With Rectal Cancer NCT05672524 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Completed | The Application Value of da Vinci Linear Cutting Stapler SureForm in Robotic Anus Preserving Surgery for Recta NCT05667181 | Nanchang University | N/A |
| Completed | A Study of CTX-009 in Adult Patients With Metastatic Colorectal Cancer NCT05513742 | Compass Therapeutics | Phase 2 |
| Completed | Multiple Firings in Double-stapled Colorectal Anastomosis NCT05498506 | Shanghai Minimally Invasive Surgery Center | — |
| Recruiting | Magnetomotoric Ultrasound (MMUS) in Rectal Cancer NCT05052086 | Region Skane | N/A |
| Unknown | Neoadjuvant Bevacizumab + Chemotherapy Combined With Short-course Radiotherapy NCT05111860 | Shanghai Minimally Invasive Surgery Center | Phase 1 / Phase 2 |
| Unknown | The Anatomical Localization of the Inferior Mesenteric Artery in Relation to the Left Colonic Artery NCT05651971 | Tang-Du Hospital | — |
| Unknown | Neoadjuvant Treatment of Fruquintinib Combined With Concurrent Chemoradiotherapy for LARC NCT05575635 | Henan Provincial People's Hospital | Phase 2 |
| Recruiting | Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS) NCT06340646 | Washington University School of Medicine | N/A |
| Completed | Pilot Study of Individualized Comprehensive Rehabilitation in Patients With Colorectal Cancer NCT07428239 | Institute of Oncology Ljubljana | N/A |
| Completed | Neoadjuvant Chemoradiation Therapy Combined With Immunotherapy for MSS Ultra-low Rectal Cancer NCT05215379 | Changhai Hospital | Phase 2 / Phase 3 |
| Recruiting | A Study to Validate the Safety and Feasibility of ArtiSential in Colorectal Cancer Surgery Using Prospectively NCT05566249 | Samsung Medical Center | — |
| Recruiting | F-Tryptophan PET/CT in Human Cancers NCT05556473 | Barbara Ann Karmanos Cancer Institute | Phase 1 |
| Active Not Recruiting | CRC Detection Reliable Assessment With Blood NCT05551052 | New Day Diagnostics | — |
| Completed | Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors NCT05515796 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | Phase 2 |
| Unknown | Norwegian Stoma Trial NCT05243771 | The Hospital of Vestfold | — |
| Unknown | Neoadjuvant Therapy for Locally Advanced Rectal Cancer With Fruquintinib, Toripalimab and SRT NCT05763927 | West China Hospital | Phase 2 |
| Recruiting | Organ Preservation Strategy of Total Neoadjuvant Chemoradiotherapy for Low Rectal Carcinoma NCT05563922 | Shanghai Zhongshan Hospital | Phase 2 |
| Recruiting | Flexible Colonoscope Assisted Hybrid Transanal Total Mesorectal Resection (taTME) NCT06380855 | Sun Yat-sen University | — |
| Recruiting | DETECT: Target Volume for Rectal Endoluminal Radiation Boosting NCT04927897 | Maastricht Radiation Oncology | — |
| Recruiting | Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001 NCT05254327 | University of Nebraska | Phase 2 |
| Recruiting | Chinese Colorectal Cancer Database NCT05434026 | Beijing Friendship Hospital | — |
| Completed | Stoma Discharge Reinfusion After Sphincter Preservation for Middle and Low Rectal Cancer NCT05461248 | The First Hospital of Jilin University | N/A |
| Recruiting | Short-course Radiotherapy (5×6Gy/7Gy/8Gy) Followed by Neo-adjuvant Chemotherapy for Locally Advanced Rectal Ca NCT03466424 | Fujian Medical University Union Hospital | — |
| Withdrawn | Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients NCT04379830 | McMaster University | N/A |
| Unknown | Prebiotics in Rectal Cancer NCT05516641 | Ochsner Health System | N/A |
| Completed | Effect of Precise Grip Strength Training on PICC Catheter-Related Thrombosis in Cancer Patients NCT05638048 | Junyan Zhao | N/A |
| Completed | SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer NCT04417699 | Providence Health & Services | Phase 2 |
| Recruiting | The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With NCT05984485 | Sun Yat-sen University | Phase 3 |
| Recruiting | Predicting the Efficacy of Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer Using an AI Pla NCT05523245 | Sixth Affiliated Hospital, Sun Yat-sen University | — |
| Unknown | Safety and Efficacy of CEA-targeted CAR-T for CEA-positive Advanced Malignant Solid Tumors NCT05538195 | Chongqing Precision Biotech Co., Ltd | Phase 1 / Phase 2 |
| Active Not Recruiting | Clinical Study on the Safety and Relationship of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatmen NCT07127497 | The First Affiliated Hospital of Anhui Medical University | Phase 2 |
| Completed | Physical Activity in Rectal Cancer Survivors NCT06435975 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Role of Gut Microbiota in Neoadjuvant Radioimmunotherapy for MSS, Locally Advanced Rectal Cancer NCT06898359 | Yanhong Deng | — |
| Completed | Immune Checkpoints in Predicting Response to Neoadjuvant Therapy in Rectal Cancer NCT05457075 | Istanbul Training and Research Hospital | — |
| Completed | Evaluation of a Decision Aid Tool in Rectal Cancer patiënts NCT04938336 | University Hospital, Ghent | — |
| Completed | The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer. NCT05445245 | Chang Gung Memorial Hospital | — |
| Recruiting | Liver Magnetic Resonance Imaging Before Treatment for Rectal Cancer. A Randomised Controlled Trial. NCT05215535 | Vastra Gotaland Region | N/A |
| Recruiting | A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists W NCT05024097 | Weill Medical College of Cornell University | Phase 2 |
| Completed | Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancie NCT05462314 | Viome | — |
| Recruiting | Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision NCT05233787 | University Hospital, Bordeaux | N/A |
| Active Not Recruiting | A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants Wi NCT05009069 | Hoffmann-La Roche | Phase 2 |
| Unknown | Rectal Cancer Shared Care NCT04966819 | Jewish General Hospital | N/A |
| Completed | Impact of Quality of Life in the Patients With Sleep Disturbance From Low Anterior Resection Syndrome in Advan NCT06271629 | Seoul National University Hospital | — |
| Recruiting | Early Ileostomy Closure for Rectal Cancer Patients in North America NCT05027737 | Jewish General Hospital | N/A |
| Unknown | The Pandemic's Effect on Diagnosis and Treatment of Rectal Cancer NCT05328960 | Sahlgrenska University Hospital | — |
| Terminated | Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant P NCT05179837 | Washington University School of Medicine | N/A |
| Recruiting | Resilience and Equity in Aging, Cancer, and Health (REACH) NCT04674267 | Dana-Farber Cancer Institute | N/A |
| Completed | Study on Fatigue in Colorectal Cancer Survivors, a Lifestyle Intervention NCT05390398 | Wageningen University | N/A |
| Terminated | SafeHeal Colovac Colorectal Anastomosis Protection Device Evaluation (SAFE-2) Pivotal Study NCT05010850 | SafeHeal Inc | N/A |
| Active Not Recruiting | Transanal Irrigation for the Management of LARS NCT05007015 | Jewish General Hospital | N/A |
| Recruiting | Neoadjuvant Chemoradiotherapy Plus Sintilimab for Intermediate/High Immunoscore Locally Advanced Rectal Cancer NCT05450029 | Yanhong Deng | Phase 2 |
| Completed | Intraoperative Assessment of Distal Resection Margins Using Frozen Section in Mid and Low Rectal Cancer Surger NCT07398716 | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | N/A |
| Enrolling By Invitation | Chemotherapy Combined With High-dose Radiotherapy for Low Rectal Cancer Using MR Guided Linear Accelerator NCT05338866 | Sun Yat-sen University | — |
| Completed | Enhanced Recovery After Laparoscopic Colorectal Surgery NCT05406765 | University Hospital of North Norway | Phase 4 |
| Unknown | Timing Evaluation of Stoma Closure (TIMES). Early vs Late Closure of Stoma After Rectal Cancer Surgery. NCT05284864 | Hospital Universitario La Fe | N/A |
| Unknown | Chemotherapy and Tislelizumab With Split-course HFRT for Locally Advanced Rectal Cancer NCT05176964 | Fujian Medical University Union Hospital | — |
| Active Not Recruiting | Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer NCT02403505 | Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair | Phase 1 |
| Completed | Prehabilitation During Neoadjuvant Chemoradiotherapy for Rectal Cancer NCT06542354 | Fudan University | N/A |
| Completed | Healing of Rectal Anastomosis Sealed With a Concentrate Derived From the Patient's Blood, After Rectal Cancer NCT05293054 | University of Aarhus | — |
| Unknown | Efferent Loop Stimulation Previous to Ileostomy Closure. Ileostim Trial. NCT05302557 | Universidad de León | N/A |
| Recruiting | Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecT NCT05136326 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Phase 2 |
| Recruiting | Multicenter Study on Postoperative Urinary and Sexual Function During Laparoscopic Functional Total Mesorectum NCT05049317 | Renmin Hospital of Wuhan University | N/A |
| Not Yet Recruiting | Robotic vs. TaTME Rectal Surgery (ROTA STUDY) NCT04200027 | Odense University Hospital | — |
| Recruiting | Targeted Optical Biopsy for Local Rectal Scars in Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy NCT05316103 | Nanfang Hospital, Southern Medical University | N/A |
| Completed | The Development of a Patient Reported Outcomes Measure Committed to the Watch-and-wait Program for Rectal Canc NCT05040646 | Maastricht University Medical Center | — |
| Recruiting | Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit) NCT05056077 | University of California, San Francisco | N/A |
| Unknown | Neoadjuvant Cetuximab + Chemotherapy Combined With Short-course Radiotherapy NCT04923620 | Shanghai Minimally Invasive Surgery Center | — |
| Recruiting | Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes NCT04907643 | Cedars-Sinai Medical Center | N/A |
| Unknown | Mitochondria Preservation by Exercise Training: a Targeted Therapy for Cancer and Chemotherapy-induced Cachexi NCT05028192 | University of Turin, Italy | — |
| Active Not Recruiting | A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Tr NCT04852653 | University Hospital, Bordeaux | — |
| Recruiting | Artificial Intelligence Assists Surgeons' Decision Making NCT04999007 | Jichao Qin | N/A |
| Recruiting | Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorect NCT05424692 | Peking Union Medical College Hospital | N/A |
| Recruiting | Patient Reported Outcomes Following Cancer of the Rectum NCT04936581 | University Hospital Gregorio Marañón | — |
| Terminated | Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy NCT05018325 | Washington University School of Medicine | N/A |
| Recruiting | Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer NCT05201430 | Fudan University | Phase 3 |
| Active Not Recruiting | Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/II NCT04922853 | West China Hospital | Phase 3 |
| Completed | Capecitabine-based Chemoradiotherapy in Combination With the IL-1 Receptor Antagonist Anakinra for Rectal Canc NCT04942626 | Goethe University | Phase 1 |
| Unknown | Management of LLN Metastasis in Locally Advanced Rectal Cancer: A Prospective Radiation Dose Escalation Study NCT04991090 | Sixth Affiliated Hospital, Sun Yat-sen University | N/A |
| Unknown | Planned Non-operative Management for Rectal Cancer NCT05241574 | Maria Sklodowska-Curie National Research Institute of Oncology | Phase 2 |
| Completed | DataBase for Analysis of Rectal Cancer Oncological Results NCT04947020 | Jagiellonian University | — |
| Completed | Perineal Flap Reconstruction Following Surgery for Advanced Pelvic Malignancy NCT05074082 | St Vincent's University Hospital, Ireland | — |
| Active Not Recruiting | Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy and Camrelizumab in Locally Advanced Rectal Can NCT04928807 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 3 |
| Completed | Gender Differences in Robotic Surgery for Rectal Cancer: a Retrospective Study NCT06391060 | Daorong Wang | — |
| Recruiting | Chemoradiation and Consolidation Chemotherapy With or Without Oxaliplatin for Distal Rectal Cancer and Watch a NCT05000697 | Hospital Alemão Oswaldo Cruz | N/A |
| Completed | TRUS-FNA For The Prediction Of pCR After Neoadjuvant Treatment In Rectal Cancer NCT04939103 | Sixth Affiliated Hospital, Sun Yat-sen University | — |
| Completed | Electric Tubular Anastomosis in Rectal Cancer NCT05879172 | LI XIN-XIANG | N/A |
| Unknown | Early and Late Removal of the Urinary Catheter After Rectum Resection NCT05020613 | Marmara University | N/A |