NCT05759741

Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy

Alterations of Gut Microbiome, Function, and Its Intervention After Total Mesorectal Excision With Defunctioning Ileostomy for Mid-low Rectal Cancer

• Status: Unknown
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Huashan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study focused on the alterations of gut microbiome and function during defunctioning ileostomy, and observed the effects of probiotic intervention on intestinal microbiome and function. The investigators looked forward to find the specific intestinal maladjusted flora from this work, which could provide a new scheme for the subsequent treatment of the damaged intestinal function and the reduction of the incidence of postoperative complication.

Conditions

• Ileostomy - Stoma
• Rectal Cancer
• Microbial Disease
• Intestinal Functional Disorder

Interventions

Type	Name	Description
DRUG	MIYAIRI 588	4 tablets of MIYAIRI 588 were inserted into the distal ileostomy once a week for 6 months

Timeline

• Start date: 2023-01-17
• Primary completion: 2024-07-17
• Completion: 2024-07-17
• First posted: 2023-03-08
• Last updated: 2023-03-14

Locations

1 site across 1 country: China