| Not Yet Recruiting | my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults NCT07516353 | Dana-Farber Cancer Institute | N/A |
| Not Yet Recruiting | Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma NCT07514819 | St. Jude Children's Research Hospital | N/A |
| Recruiting | Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas NCT06465199 | Milton S. Hershey Medical Center | Phase 1 / Phase 2 |
| Not Yet Recruiting | Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma NCT07321912 | Milton S. Hershey Medical Center | Phase 2 |
| Recruiting | A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People Wit NCT07477457 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Recruiting | Apatinib Combined With Liposomal Irinotecan for Refractory or Metastatic Osteosarcoma NCT07479732 | Peking University People's Hospital | Phase 1 / Phase 2 |
| Recruiting | Atezolizumab in Combination With Stereotactic Body Radiation Therapy (SBRT) and Surgery for Relapsed Osteosarc NCT06492954 | Emory University | Phase 1 |
| Recruiting | Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors NCT06625190 | University of Florida | Phase 1 / Phase 2 |
| Recruiting | Musculoskeletal Cancers Remote Monitoring and Care NCT07129226 | Case Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | Envafolimab Combined With Neoadjuvant Chemotherapy Treat Stage IIb Resectable Osteosarcoma Patients NCT07142863 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | Phase 2 |
| Not Yet Recruiting | Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas NCT07052383 | Tcelltech Inc. | Phase 1 |
| Active Not Recruiting | Study of HS-20093 Versus Gemcitabine in Combination With Docetaxel in Treatment of Osteosarcoma After Previous NCT06935409 | Hansoh BioMedical R&D Company | Phase 3 |
| Active Not Recruiting | A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer NCT06521567 | GlaxoSmithKline | Phase 1 / Phase 2 |
| Not Yet Recruiting | Precision Therapy Based on Immune Microenvironment by Transcriptome Sequencing of Osteosarcoma, a Prospective, NCT06776198 | Peking University People's Hospital | — |
| Recruiting | Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomi NCT06709495 | David S Shulman, MD | Phase 1 / Phase 2 |
| Not Yet Recruiting | Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy NCT06726512 | University Medical Center Groningen | N/A |
| Recruiting | A Phase 2 Pilot Study to Evaluate the Safety and the Anti-Tumour Activity of the Myc Inhibitor OMO-103 Adminis NCT06650514 | Vall d'Hebron Institute of Oncology | Phase 2 |
| Not Yet Recruiting | ARTEMIS-103: Phase 1b Study of HS-20093 Combinations in Patients with Bone and Soft Tissue Sarcoma. NCT06699576 | Hansoh BioMedical R&D Company | Phase 1 |
| Recruiting | PET-imaging of Two Vartumabs in Patients With Solid Tumors NCT06645808 | Var2 Pharmaceuticals | EARLY_Phase 1 |
| Completed | Intra-arterial Cisplatin Plus Rh-endostatin Combined With Systematic Chemotherapy in Osteosarcoma NCT06562673 | Shanghai 6th People's Hospital | Phase 1 / Phase 2 |
| Terminated | Effects of Maintenance Cabozantinib+BSC Versus BSC in Children and AYA With Osteosarcoma NCT06341712 | Ipsen | Phase 2 |
| Recruiting | Trilaciclib Combing Chemotherapy in the Neoadjuvant Treatment of Osteosarcoma NCT06714383 | Peking University People's Hospital | Phase 2 |
| Recruiting | Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors NCT06541262 | Milton S. Hershey Medical Center | Phase 1 / Phase 2 |
| Not Yet Recruiting | Assessing Clinical Trial Experiences of Patients With Osteosarcoma NCT05535283 | Power Life Sciences Inc. | — |
| Active Not Recruiting | Exploring the Expression Level of Cadherin 6 Protein (CDH6) in Primary Malignant Bone Tumor Specimens and Its NCT06850506 | Peking University People's Hospital | — |
| Not Yet Recruiting | Single High-dose Brachytherapy for Giant Osteosarcoma Masses NCT06524778 | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | Phase 2 |
| Recruiting | Agnostic Therapy in Rare Solid Tumors NCT06638931 | Instituto do Cancer do Estado de São Paulo | Phase 2 |
| Recruiting | Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors NCT06500819 | Crystal Mackall, MD | Phase 1 |
| Recruiting | Safety and Feasibility of Intraoperative Visualization With Cytalux in Children NCT06235125 | Ann & Robert H Lurie Children's Hospital of Chicago | Phase 1 |
| Recruiting | Upfront Surgical Resection for Osteosarcoma NCT06384404 | Montefiore Medical Center | — |
| Recruiting | A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning NCT06387485 | Ricoh USA, Inc. | N/A |
| Terminated | TQB2928 Injection Combined Anlotinib Hydrochloride Capsule in Recurrent/Metastatic Osteosarcoma and Other Soli NCT06438783 | Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. | Phase 1 |
| Recruiting | An Organoid-based Functional Precision Medicine Trial in Osteosarcoma NCT06064682 | Jonsson Comprehensive Cancer Center | — |
| Unknown | Trilaciclib Combined With Chemotherapy for Perioperative Treatment of Osteosarcoma NCT06217003 | The First Affiliated Hospital of Xinxiang Medical College | Phase 2 |
| Recruiting | Donor Site Morbidity After Free Vascularized Fibular Graft NCT06324916 | Assiut University | — |
| Recruiting | A Clinical Study of Surufatinib Combined With Chemotherapy as Neoadjuvant Treatment in Osteosarcoma NCT05926492 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Unknown | Tucidinostat Plus Apatinib for Advanced Osteosarcoma NCT06125171 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 |
| Recruiting | B7-H3 NIR Imaging for Osteosarcoma Surgery NCT06778603 | Peking University People's Hospital | Phase 1 / Phase 2 |
| Recruiting | Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas NCT06156410 | Children's Hospital of Philadelphia | Phase 1 |
| Recruiting | Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy NCT06029218 | Centre Antoine Lacassagne | N/A |
| Recruiting | SPEARHEAD-3 Pediatric Study NCT05642455 | USWM CT, LLC | Phase 1 / Phase 2 |
| Recruiting | A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors NCT06171282 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Recruiting | ARTEMIS-002: HS-20093 in Patients With Relapsed or Refractory Osteosarcoma and Other Sarcomas NCT05830123 | Hansoh BioMedical R&D Company | Phase 2 |
| Recruiting | Soluble B7-H3 as a Biomarker for Osteosarcoma NCT05942456 | Peking University People's Hospital | — |
| Recruiting | Pulmonary Resectable Osteosarcoma Treated by Metastasectomy and Pre-operative Immunotherapy and Stereotactic B NCT06114225 | Ruijin Hospital | Phase 2 |
| Recruiting | Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Pro NCT05588648 | MedPacto, Inc. | Phase 1 / Phase 2 |
| Recruiting | A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Ti NCT05851456 | Shanghai Yunying Medical Technology | EARLY_Phase 1 |
| Recruiting | Use of GnRHa During Chemotherapy for Fertility Protection NCT05328258 | Kenny Rodriguez-Wallberg | Phase 3 |
| Completed | Quality of Life of Patients With Bone Tumor of the Lower Limbs Treated With Salvage Surgery NCT05772312 | Istituto Ortopedico Rizzoli | — |
| Active Not Recruiting | START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer NCT05492682 | Valo Therapeutics Oy | Phase 1 |
| Not Yet Recruiting | A Study of Sulfatinib on Relapsed or Refractory Drug Resistant Osteosarcoma NCT05590572 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 1 / Phase 2 |
| Recruiting | Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salva NCT05779670 | Istituto Ortopedico Rizzoli | — |
| Not Yet Recruiting | Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas NCT05515068 | Klinikum Stuttgart | — |
| Unknown | Safety and Efficacy of NK510 to Treat Osteosarcoma and Soft Tissue Sarcoma NCT06117878 | Base Therapeutics (Shanghai) Co., Ltd. | EARLY_Phase 1 |
| Recruiting | AOH1996 for the Treatment of Refractory Solid Tumors NCT05227326 | City of Hope Medical Center | Phase 1 |
| Withdrawn | A Dose Finding Study of CycloSam® Combined With External Beam Radiotherapy NCT03612466 | Albert Einstein College of Medicine | Phase 1 |
| Recruiting | B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3 NCT04897321 | St. Jude Children's Research Hospital | Phase 1 |
| Recruiting | An Observational Study of Local Relapse After High Grade Osteosarcoma NCT06017518 | Istituto Ortopedico Rizzoli | — |
| Active Not Recruiting | A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Paren NCT05312411 | Seattle Children's Hospital | Phase 1 |
| Active Not Recruiting | Regorafenib in Patients With Refractory Primary Bone Tumors NCT05395741 | Institute of Mother and Child, Warsaw, Poland | Phase 1 / Phase 2 |
| Recruiting | Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas NCT05182164 | Institut Bergonié | Phase 2 |
| Recruiting | Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma NCT05235165 | Children's Oncology Group | Phase 3 |
| Withdrawn | Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma NCT05116800 | Brown University | Phase 2 |
| Completed | Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors NCT05302921 | Children's National Research Institute | Phase 2 |
| Recruiting | Early Ageing During Therapy in AYA Cancer Patients NCT05062707 | University Medical Center Groningen | — |
| Completed | Prehabilitation to Improve Cancer Surgery Outcomes in AYA Patients With Extremity Sarcomas NCT04248959 | University Health Network, Toronto | N/A |
| Unknown | Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary B NCT05057130 | Blokhin's Russian Cancer Research Center | Phase 2 / Phase 3 |
| Recruiting | HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced NCT04995003 | Baylor College of Medicine | Phase 1 |
| Completed | A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With NCT05093322 | Hutchmed | Phase 1 / Phase 2 |
| Unknown | Efficacy of Epidural Analgesia in Lower Extremity Osteosarcoma NCT04945512 | Istanbul University | N/A |
| Completed | Extracorporeal Shock Wave Therapy on Osteoblast-Like Cells In- Vitro Study NCT05801887 | Krishnadevaraya College of Dental Sciences & Hospital | N/A |
| Unknown | Efficacy of Exercise Program on Osteosarcoma Patients NCT04757064 | Cairo University | N/A |
| Completed | Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirem NCT05024253 | Children's Cancer Hospital Egypt 57357 | Phase 3 |
| Completed | A Study of Azenosertib (ZN-c3) in Combination With Gemcitabine in Subjects With Osteosarcoma NCT04833582 | K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc | Phase 1 |
| Recruiting | Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcoma NCT04698785 | Centre Leon Berard | Phase 2 |
| Completed | The Prognostic Value of Serum Biomarkers in Osteosarcoma NCT05093101 | Istituto Ortopedico Rizzoli | — |
| Active Not Recruiting | SARC038: Phase 2 Study of Regorafenib and Nivolumab in Osteosarcoma NCT04803877 | Sarcoma Alliance for Research through Collaboration | Phase 2 |
| Terminated | IBI188 Combination Therapy in Solid Tumors NCT04861948 | Innovent Biologics (Suzhou) Co. Ltd. | Phase 1 |
| Unknown | Clinical Study of CD276 Targeted Autologous Chimeric Antigen Receptor T Cell Infusion in Patients With CD276 P NCT04864821 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | EARLY_Phase 1 |
| Completed | The Registry of Oncology Outcomes Associated With Testing and Treatment NCT04028479 | Taproot Health | — |
| Unknown | A Study to Evaluate the Safety and Efficacy of ALMB-0168 in Patients With Osteosarcoma NCT04886765 | AlaMab Therapeutics (Shanghai) Inc. | Phase 1 / Phase 2 |
| Unknown | Dietary Habits, Metabolome, Immune Profile and Microbiota in Patients With Bone Sarcoma NCT04735289 | Istituto Ortopedico Rizzoli | — |
| Suspended | Trastuzumab Deruxtecan for the Treatment of HER2+ Newly Diagnosed or Recurrent Osteosarcoma NCT04616560 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse NCT04758000 | Istituto Ortopedico Rizzoli | Phase 2 |
| Terminated | 18F-FTC-146 PET/CT in Newly-Diagnosed Osteosarcoma NCT04365660 | Davidzon, Guido, M.D. | Phase 2 |
| Recruiting | Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignanc NCT04282044 | BioEclipse Therapeutics | Phase 1 |
| Unknown | Predictive Models of Treatment Responses and Survival Outcomes in Patients With Osteosarcoma NCT05194605 | West China Hospital | — |
| Active Not Recruiting | A Post-treatment Program to Identify and Manage Complications Related to Oncology or Hematology Treatments in NCT04671693 | Centre Leon Berard | N/A |
| Active Not Recruiting | Olaparib With Ceralasertib in Recurrent Osteosarcoma NCT04417062 | Dana-Farber Cancer Institute | Phase 2 |
| Completed | Drug Sensitivity and Mutation Profiling NCT04956198 | Florida International University | — |
| Completed | Construction of Microfluidic Exosome Chip for Diagnosis of Lung Metastasis of Osteosarcoma NCT05101655 | Ruijin Hospital | — |
| Unknown | Phase II Clinical Trial Scheme of Ganoderma Lucidum Spore Powder for Postoperative Chemotherapy of Osteosarcom NCT04319874 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Unknown | A Phase I Clinical Trial of Neoadjuvant Chemotherapy With/Without SPIONs/SMF for Patients With Osteosarcoma NCT04316091 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 1 |
| Active Not Recruiting | B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults NCT04483778 | Seattle Children's Hospital | Phase 1 |
| Unknown | Comparison of MAPI+Camrelizumab Versus API+Apatinib Versus MAPI in Patients With a Poor Response to Preoperati NCT04351308 | Peking University People's Hospital | Phase 2 |
| Completed | A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, NCT04154189 | Eisai Inc. | Phase 2 |
| Recruiting | Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sar NCT04055220 | Centre Leon Berard | N/A |
| Unknown | Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy in the Treatment of Osteosarcoma NCT04294511 | Sun Yat-sen University | Phase 2 |
| Unknown | Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR NCT04461223 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Recruiting | ICONIC: Improving Outcomes Through Collaboration in OsteosarComa NCT04132895 | University College, London | — |
| Recruiting | Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration NCT04040205 | Medical College of Wisconsin | Phase 2 |
| Active Not Recruiting | Nivolumab or Nivolumab and Azacitidine in Patients With Recurrent, Resectable Osteosarcoma NCT03628209 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 |
| Recruiting | Losartan + Sunitinib in Treatment of Osteosarcoma NCT03900793 | University of Colorado, Denver | Phase 1 |
| Completed | Cancer Genome Study Using Samples From Patients Treated on Clinical Trial SHR1020-SHR-1210-II-OS NCT03997747 | Peking University People's Hospital | — |
| Unknown | Pulmonary Resectable Metastases of Osteosarcoma With Anti-angiogenics and CHemotherapy NCT03742193 | Ruijin Hospital | Phase 2 |
| Active Not Recruiting | EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults NCT03618381 | Seattle Children's Hospital | Phase 1 |
| Active Not Recruiting | Dose Escalation Study of CLR 131 in Pediatric Relapsed/Refractory Malignant Tumors Including Neuroblastoma and NCT03478462 | Cellectar Biosciences, Inc. | Phase 1 |
| Active Not Recruiting | Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma NCT03960177 | OHSU Knight Cancer Institute | EARLY_Phase 1 |
| Terminated | Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/R NCT03860207 | Y-mAbs Therapeutics | Phase 1 / Phase 2 |
| Recruiting | Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma or Relapsed/ NCT03721068 | UNC Lineberger Comprehensive Cancer Center | Phase 1 |
| Completed | M6620 (VX-970) in Selected Solid Tumors NCT03718091 | Massachusetts General Hospital | Phase 2 |
| Active Not Recruiting | Mifamurtide Combined With Post-operative Chemotherapy for Newly Diagnosed High Risk Osteosarcoma Patients NCT03643133 | UNICANCER | Phase 2 |
| Unknown | A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma NCT03676985 | Lee's Pharmaceutical Limited | Phase 1 / Phase 2 |
| Unknown | Proteomics Research of Osteosarcoma NCT03932058 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Terminated | Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients NCT03458728 | Bayer | Phase 1 / Phase 2 |
| Active Not Recruiting | Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO) NCT03496402 | Institut Curie | N/A |
| Withdrawn | Treatment of Relapsed or Refractory Neuroblastoma and Osteosarcoma With Expanded Haploidentical NK Cells and H NCT03209869 | University of Wisconsin, Madison | Phase 1 |
| Recruiting | Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas NCT03442465 | Memorial Sloan Kettering Cancer Center | — |
| Recruiting | Pediatric PET/MR Image Registry NCT03458520 | Stanford University | — |
| Unknown | Patient-derived Xenograft (PDX) Modeling to Test Drug Response for High-grade Osteosarcoma NCT03358628 | Peking University People's Hospital | — |
| Unknown | Feasibility Study of Interval Compressed Regimen Using Four-drugs for Osteosarcoma NCT03390946 | Byung-Kiu Park | Phase 2 |
| Unknown | The Osteosarcoma Biobank in Peking University People's Hospital NCT03362086 | Peking University People's Hospital | — |
| Active Not Recruiting | Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or O NCT03373097 | Bambino Gesù Hospital and Research Institute | Phase 1 / Phase 2 |
| Completed | Osteosarcoma in Patients Older Than 40 Years. Prognostic Factors and Survival NCT03911245 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Biospecimen Analysis in Determining Effects of Chemotherapy on Fertility in Osteosarcoma Survivors NCT03206450 | Children's Oncology Group | — |
| Terminated | Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies NCT03422679 | Cellestia Biotech AG | Phase 1 / Phase 2 |
| Unknown | A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma NCT02982486 | Assaf-Harofeh Medical Center | Phase 2 |
| Completed | Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or H NCT03220035 | National Cancer Institute (NCI) | Phase 2 |
| Terminated | A Study of Pembrolizumab in Patients With Relapsed Or Metastatic Osteosarcoma Not Eligible for Curative Surger NCT03013127 | Oslo University Hospital | Phase 2 |
| Active Not Recruiting | Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wi NCT02867592 | National Cancer Institute (NCI) | Phase 2 |
| Unknown | Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma NCT03108677 | Ruijin Hospital | — |
| Unknown | Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. NCT03242382 | Grupo Espanol de Investigacion en Sarcomas | Phase 2 |
| Completed | A Phase II Trial of Avelumab in Patients With Recurrent or Progressive Osteosarcoma NCT03006848 | St. Jude Children's Research Hospital | Phase 2 |
| Completed | Biology of Osteosarcoma (BOOST) Registry and Biobank NCT03225872 | University of Minnesota | — |
| Unknown | Clinical Trial Evaluating Metronomic Chemotherapy in Patients With Metastatic Osteosarcoma NCT03063983 | Grupo de Apoio ao Adolescente e a Crianca com Cancer | Phase 2 |
| Terminated | Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma, Rhabdomyosarcoma, and Wilms T NCT02581384 | Dana-Farber Cancer Institute | Phase 1 / Phase 2 |
| Withdrawn | HIFU Hyperthermia With Liposomal Doxorubicin (DOXIL) for Relapsed or Refractory Pediatric and Young Adult Soli NCT02557854 | Theodore Laetsch | Phase 1 |
| Completed | Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors NCT02982941 | MacroGenics | Phase 1 |
| Unknown | Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer NCT02856048 | Assistance Publique - Hôpitaux de Paris | Phase 2 / Phase 3 |
| Completed | Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma NCT02945800 | H. Lee Moffitt Cancer Center and Research Institute | Phase 2 |
| Terminated | A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumor NCT02536183 | AeRang Kim | Phase 1 |
| Withdrawn | Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors NCT02689336 | Washington University School of Medicine | Phase 2 |
| Terminated | Phase II Trial for the Treatment of Relapsed Osteosarcoma NCT02718482 | Italian Sarcoma Group | Phase 2 |
| Completed | NAC to Prevent Cisplatin-induced Hearing Loss NCT02094625 | Children's Hospital Los Angeles | Phase 1 |
| Completed | Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy NCT02711007 | GUO WEI | Phase 2 / Phase 3 |
| Recruiting | Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and S NCT02508038 | University of Wisconsin, Madison | Phase 1 |
| Completed | Diffusion Weighted Magnetic Resonance in Imaging Younger Patients With Newly Diagnosed Bone or Soft Tissue Sar NCT02415816 | St. Jude Children's Research Hospital | N/A |
| Completed | Metronomic Chemotherapy in Patients With Advanced Solid Tumor With Bone Metastasis and Advanced Pretreated Ost NCT02517918 | Institut Bergonié | Phase 1 |
| Completed | Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors NCT02390843 | Emory University | Phase 1 |
| Completed | Study of Lenvatinib in Children and Adolescents With Refractory or Relapsed Solid Malignancies and Young Adult NCT02432274 | Eisai Limited | Phase 1 / Phase 2 |
| Completed | Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies NCT02223052 | Celgene | Phase 1 |
| Completed | Monocyte Phenotypic and Functional Differences NCT02132182 | Duke University | — |
| Terminated | A Eurosarc Study of Mifamurtide in Advanced Osteosarcoma (MEMOS) NCT02441309 | University of Oxford | Phase 2 |
| Completed | A Retrospective Non-intervention Study to Characterize FOlate Rescue Treatment in Osteosarcoma Patients Treate NCT02383901 | Isofol Medical AB | — |
| Completed | Pretreatment Anti-Therapeutic Antibodies (PATA) in Patients Treated With hu14.18K322A Antibody NCT02159443 | St. Jude Children's Research Hospital | — |
| Completed | Molecular-Guided Therapy for Childhood Cancer NCT02162732 | Giselle Sholler | N/A |
| Completed | ABCB1/P-glycoprotein Expression Influence on Non-metastatic Osteosarcoma of the Extremities NCT04383288 | Grupo Espanol de Investigacion en Sarcomas | — |
| Active Not Recruiting | iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma NCT01953900 | Baylor College of Medicine | Phase 1 |
| Completed | MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors NCT02076906 | AeRang Kim | Phase 1 |
| Recruiting | Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Canc NCT01790152 | Children's Oncology Group | — |
| Completed | A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With NCT02107963 | National Cancer Institute (NCI) | Phase 1 |
| Terminated | Cryoablation, Radiofrequency Ablation, or Microwave Ablation in Treating Patients With Metastatic Sarcoma Stab NCT01986829 | Washington University School of Medicine | Phase 2 |
| Unknown | Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophos NCT02013336 | South Plains Oncology Consortium | Phase 1 |
| Completed | Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patien NCT01987102 | Isofol Medical AB | Phase 1 / Phase 2 |
| Terminated | Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With NCT01987596 | Barbara Ann Karmanos Cancer Institute | Phase 3 |
| Unknown | Haploidentical Stem Cell Transplantation and NK Cell Therapy in Patients With High-risk Solid Tumors NCT01807468 | Samsung Medical Center | Phase 2 |
| Completed | Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy NCT01848457 | Children's Hospital of Philadelphia | Phase 2 |
| Terminated | Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung NCT01759303 | Emerald Clinical Inc. | Phase 2 |
| Terminated | Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors NCT02100891 | Monica Thakar | Phase 2 |
| Terminated | Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma NCT01882231 | Vanderbilt-Ingram Cancer Center | N/A |
| Unknown | Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma NCT01669369 | Sun Yat-sen University | Phase 4 |
| Completed | Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors NCT01661400 | Washington University School of Medicine | Phase 1 |
| Unknown | A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX NCT01758666 | Tianjin Medical University Cancer Institute and Hospital | N/A |
| Completed | Effects of Preoperative Physical Therapy in Patients With Lower Extremity Malignancy NCT01674101 | St. Jude Children's Research Hospital | N/A |
| Completed | Trial With Gemcitabine and Rapamycin in Second Line of Metastatic Osteosarcoma NCT02429973 | Broto, Javier Martín, M.D. | Phase 2 |
| Withdrawn | Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting NCT01492569 | Stanford University | N/A |
| Terminated | Eltrombopag for the Prevention of Chemotherapy Induced Thrombocytopenia NCT01491594 | Duke University | Phase 1 |
| Completed | Dose Escalation Study of Sorafenib and Irinotecan Combination Therapy in Pediatric Patients With Solid Tumors NCT01518413 | HMeany | Phase 1 |
| Terminated | Surveillance Study of Patients With Newly Diagnosed Osteosarcoma NCT01194284 | Millennium Pharmaceuticals, Inc. | — |
| Completed | Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI NCT01336803 | Heike E Daldrup-Link | Phase 2 |
| Completed | ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcom NCT01459484 | Italian Sarcoma Group | Phase 2 |
| Completed | Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors NCT01331135 | Emory University | Phase 1 |
| Completed | Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients With Osteosarcoma NCT01005043 | University Hospital Heidelberg | Phase 1 / Phase 2 |
| Unknown | Intravenous Palifosfamide-tris in Combination With Etoposide and Carboplatin in Patients With Malignancies NCT01242072 | Alaunos Therapeutics | Phase 1 |
| Withdrawn | RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia NCT01236586 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma NCT01176981 | The Hospital for Sick Children | Phase 3 |
| Completed | Diffusion Study on Patients With Osteosarcoma NCT01615640 | Klinikum Stuttgart | — |
| Terminated | A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, If NCT01258634 | University of Chicago | Phase 1 |
| Withdrawn | A Phase I Study of Pazopanib as a Single Agent for Children With Refractory Solid Tumors NCT01130623 | National Cancer Institute (NCI) | Phase 1 |
| Withdrawn | Markers of Anthracycline-Related Cardiac Muscle Injury NCT01112800 | St. Jude Children's Research Hospital | — |
| Completed | HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors NCT00931931 | Timothy Cripe | Phase 1 |
| Completed | Genetic Biomarkers in Tissue Samples From Patients With Osteosarcoma NCT01807143 | Children's Oncology Group | — |
| Active Not Recruiting | Methionine PET/CT Studies In Patients With Cancer NCT00840047 | St. Jude Children's Research Hospital | Phase 2 |
| Completed | Adjuvant High-Dose Thiotepa and Stem Cell Rescue Associated With Conventional Chemotherapy in Relapsed Osteosa NCT00978471 | Centre Leon Berard | Phase 2 |
| Unknown | Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young NCT01780779 | Universitaire Ziekenhuizen KU Leuven | — |
| Terminated | A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the L NCT00752206 | Sarcoma Alliance for Research through Collaboration | Phase 2 |
| Unknown | A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma NCT01002092 | Shandong Simcere-Medgenn Bio-pharmaceutical Co., Ltd | Phase 2 |
| Completed | Informed Consent in Pediatric Cancer Trials NCT00923650 | National Cancer Institute (NCI) | — |
| Completed | A Phase I Trial Of The Humanized Anti-GD2 Antibody In Children And Adolescents With Neuroblastoma, Osteosarcom NCT00743496 | St. Jude Children's Research Hospital | Phase 1 |
| Terminated | High Dose Methotrexate With Leucovorin Rescue With or Without Glucarpidase in Osteosarcoma NCT00634322 | BTG International Inc. | Phase 2 |
| Completed | A Phase II Study of Oral Cyclophosphamide and Sirolimus (OCR) in Advanced Sarcoma NCT00743509 | University of Michigan Rogel Cancer Center | Phase 2 |
| Completed | A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma NCT00667342 | St. Jude Children's Research Hospital | Phase 2 |
| Terminated | Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted Outpatient Chemotherapy NCT00673179 | M.D. Anderson Cancer Center | N/A |
| Completed | Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without Vorax NCT00634504 | BTG International Inc. | Phase 1 |
| Unknown | Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma NCT00691236 | Tata Memorial Hospital | Phase 2 / Phase 3 |
| Unknown | Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma NCT00689195 | Tata Memorial Hospital | Phase 1 / Phase 2 |
| Completed | Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma NCT00899275 | Children's Oncology Group | — |
| Terminated | A Study to Determine the Activity of Robatumumab (SCH 717454) in Participants With Relapsed Osteosarcoma or Ew NCT00617890 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Sorafenib in Relapsed High Grade Osteosarcoma NCT00889057 | Italian Sarcoma Group | Phase 2 |
| Completed | Mifamurtide (L-MTP-PE) for High-Risk Osteosarcoma NCT00631631 | Millennium Pharmaceuticals, Inc. | — |
| Completed | Phase II Study of Intravenous Rexin-G in Osteosarcoma NCT00572130 | Epeius Biotechnologies | Phase 2 |
| Completed | Chemotherapy for Patients With Osteosarcoma NCT00523419 | Eli Lilly and Company | Phase 2 |
| Completed | A Study of Pemetrexed in Children With Recurrent Cancer NCT00520936 | Eli Lilly and Company | Phase 2 |
| Terminated | Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemothe NCT02022358 | University College, London | Phase 2 |
| Completed | Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lun NCT00503295 | Oncolytics Biotech | Phase 2 |
| Completed | Collecting and Storing Tissue From Young Patients With Cancer NCT00898755 | Children's Oncology Group | — |
| Completed | Development of Indices Predicting Response to Pre-operative Chemotherapy in Osteosarcoma Patients NCT00686738 | National Cancer Center, Korea | — |
| Recruiting | Clinical Orthopaedic Data Bank (Acute and Chronic) NCT00411060 | University of Florida | — |
| Terminated | HGS-ETR2 to Treat Children With Solid Tumors NCT00428272 | National Cancer Institute (NCI) | Phase 1 |
| Completed | ZD1839 and Oral Irinotecan in Treating Young Patients With Refractory Solid Tumors NCT00132158 | St. Jude Children's Research Hospital | Phase 1 |
| Completed | Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants Wi NCT00093080 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Phase II Study of Chemotherapy and Pamidronate for the Treatment of Newly Diagnosed Osteosarcoma NCT00586846 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Terminated | Huntsman Biopsy Study NCT00615329 | State University of New York - Upstate Medical University | — |
| Completed | Machine Learning Applied to EHRs Data of Patients With Sarcoma NCT07215728 | University of Milano Bicocca | — |
| Terminated | Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: NCT00615628 | State University of New York - Upstate Medical University | — |
| Completed | European Study in Bone Sarcoma Patients Over 40 Years NCT02986503 | Italian Sarcoma Group | — |
| Completed | Eligibility Screening for a NCI Pediatric Oncology Branch Research Study NCT00026780 | National Cancer Institute (NCI) | — |
| Completed | Liposomal Vincristine for Pediatric and Adolescent Patients With Relapsed Malignancies NCT00038207 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | Recombinant Human Thrombopoietin in Children Receiving Ifosfamide, Carboplatin, and Etoposide Chemotherapy NCT00187109 | St. Jude Children's Research Hospital | Phase 1 / Phase 2 |
| Completed | Detection of Circulating Osteosarcoma Tumor Cells in the Blood of Patients Using the Polymerase Chain Reaction NCT00588510 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric Patient NCT06162962 | Changye Zou | — |
| Completed | Osteosarcoma1999-A Study Of Intensive Chemotherapy for Osteosarcoma NCT00145639 | St. Jude Children's Research Hospital | Phase 2 |
| Active Not Recruiting | Chemotherapy Resistance in Osteogenic Sarcoma and Other Solid Tumors NCT00580385 | Memorial Sloan Kettering Cancer Center | N/A |
| Completed | Recombinant Interferon Alpha and Etoposide in Relapsed Osteosarcoma NCT00504140 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | A Phase I Study of OncoLAR® (Registered Trademark) (NSC 685403) With/Without Tamoxifen in Patients With Osteos NCT00001436 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma C NCT00180908 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 3 |
| Completed | Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chem NCT00001217 | National Cancer Institute (NCI) | Phase 3 |
| Completed | A Pilot Study for the Treatment of Patients With Metastatic and High Risk Sarcomas and Primitive Neuroectoderm NCT00001209 | National Cancer Institute (NCI) | Phase 1 |
| Available | Expanded Access Use of L-MTP-PE for the Treatment of Osteosarcoma NCT04571229 | Memorial Sloan Kettering Cancer Center | — |
| Available | BLESSED: Expanded Access for DNG64-CAR-V for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast NCT04091295 | Aveni Foundation | — |
| Completed | Clinical Studies of Gemcitabine-Oxaliplatin NCT00407433 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 2 |