Trials / Unknown
UnknownNCT01758666
A Clinical Research on the Relation of Blood Drug Concentration and Calcium Folinate Rescued in High-dose MTX Therapy
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital · Academic / Other
- Sex
- All
- Age
- 12 Years – 60 Years
- Healthy volunteers
- Not accepted
Summary
At present, the most effective drugs to osteosarcoma include ADM,DDP,,HD-MTX,IFO and so on.The effective rate of single drug was about 30%, and if the chemotherapy contains HD-MTX, the survival rate can reach about 60%, so the HD-MTX is the most important component in patients of osteosarcoma. Studies have shown that, MTX efficacy and adverse reactions were associated with blood concentration level and duration, selecting the right time and dose to give CF is the critical point.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Methotrexate,Calcium folinate |
Timeline
- Start date
- 2012-09-01
- Primary completion
- 2016-11-01
- Completion
- 2016-12-01
- First posted
- 2013-01-01
- Last updated
- 2015-12-22
Source: ClinicalTrials.gov record NCT01758666. Inclusion in this directory is not an endorsement.