NCT06162962

Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric Patient

Department of Orthopedic Oncology, The First Affiliated Hospital of Sun Yat-sen University

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 345 (actual)
• Sponsor: Changye Zou · Academic / Other
• Sex: All
• Age: 4 Years – 14 Years
• Healthy volunteers: Not accepted

Summary

Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.

Detailed description

Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (\>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.

Conditions

• Osteosarcoma
• Pediatric
• Lower Limb Injury
• Outcome

Interventions

Type	Name	Description
OTHER	Retrospective analysis	Retrospective analysis

Timeline

• Start date: 2000-01-01
• Primary completion: 2023-11-23
• Completion: 2023-11-23
• First posted: 2023-12-08
• Last updated: 2023-12-08

Locations

1 site across 1 country: China