NCT03108677

Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma

A Pilot Study of Circulating Exosome RNA as Diagnostic and Prognostic Markers in Lung Metastases of Primary High-Grade Osteosarcoma

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 90 (actual)
• Sponsor: Ruijin Hospital · Academic / Other
• Sex: All
• Age: 12 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to learn whether the profile of RNA from circulating exosomes can be used as a biomarker for lung metastases of primary high-grade osteosarcoma. Circulating exosomes plays roles in metastases in many kinds of cancer including osteosarcoma. By RNA profiling researchers may find lung metastases earlier than conventional work-up and predict the oncological outcomes.

Detailed description

Investigators have performed a 4 patients pilot study under the oversight of hospital's ethics committee, and investigator found that the levels and mutations of circulating exosome RNA from patients with or without lung metastasis have significant differences. Then investigators wish to register this study to do a further research, in order to reveal the roles of circulating exosome RNA in metastases of osteosarcoma.

Conditions

• Lung Metastases
• Osteosarcoma

Interventions

Type	Name	Description
OTHER	Blood samples	15 ml peripheral blood

Timeline

• Start date: 2017-05-01
• Primary completion: 2023-09-19
• Completion: 2023-12-30
• First posted: 2017-04-11
• Last updated: 2023-10-03

Locations

1 site across 1 country: China