NCT03911245

Osteosarcoma in Patients Older Than 40 Years. Prognostic Factors and Survival

Our Experience About Limb and Pelvic Osteosarcoma in Patients Older Than 40 Years and Comparative Study With the Age Group < 40 Years. Prognostic Factors, Survival, Amputation Rate and Limb Salvage Surgery After Neoadjuvant Chemotherapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 195 (actual)
• Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of this work is to carry out an exhaustive analysis of the characteristics of osteosarcoma in patients with an age equal to or greater than 40 years, in the Hospital de la Santa Creu and Sant Pau in Barcelona, during the years 1986-2016, with the objective to establish the factors that determine the disease and survival, as well as to evaluate the rates of limb salvage and amputation after neodyuvant chemotherapy. With the result of the results, the report of osteosarcoma and the age less than 40 years, with the aim of providing new information that is related to the appearance of osteosarcoma is available from 40 years.

Detailed description

The main objectives of this study are the following: * Describe the prognostic factors of osteosarcoma in patients aged 40 years or older, treated at the Hospital de la Santa Creu and Sant Pau in Barcelona during the years 1986-2016, as well as overall survival and disease-free survival. * Quantify the frequency of limb salvage surgery and amputation, determining the influence of the use of neoadjuvant chemotherapy in the definitive therapeutic management. * Compare the results obtained with a group formed patients with a range of less than 40 years, diagnosed and treated with osteosarcoma at the Hospital de la Santa Creu i Sant Pau in Barcelona during the same period of years. The secondary objectives of this study are the following: * Analyze the frequency of occurrence of local recurrence. * Determine postoperative complications. * Evaluate the frequency of distant spread of the disease. * Describe the characteristics of the group of patients in the study. * Demonstrate that the incidence of osteosarcoma in adulthood is increasing over the years. * Determine predisposing factors or lesions to the appearance of osteosarcoma not described in the literature.

Conditions

• Osteosarcoma

Interventions

Type	Name	Description
OTHER	Retrospective study. Analyze of data in medical records	Retrospective study. Analyze of data in medical records

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2019-04-11
• Last updated: 2019-04-11

Locations

1 site across 1 country: Spain