| Recruiting | Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy NCT07386444 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Pilot Trial of a Clinical Decision-Support App for Managing Emergencies Among Clinicians in a Rural Ugandan Ho NCT07257705 | University of Milano Bicocca | N/A |
| Not Yet Recruiting | Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer NCT06791057 | Massachusetts General Hospital | N/A |
| Recruiting | Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism NCT07143539 | Insel Gruppe AG, University Hospital Bern | N/A |
| Not Yet Recruiting | Evaluating Dyspnea in Autoimmune Myasthenia Gravis "Why am I Short of Breath?" NCT06866652 | Institut de Myologie, France | — |
| Completed | INSPIRatory Efforts Estimation Under High-flow Nasal Oxygen NCT07228676 | Poitiers University Hospital | N/A |
| Recruiting | LUng and Cardiac Ultrasound for REspiratory Distress in ElDerly NCT06807983 | University Hospital, Toulouse | N/A |
| Recruiting | Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound NCT07324980 | Università degli Studi del Piemonte Orientale Amedeo Avogadro | — |
| Not Yet Recruiting | Hypnosis on Breathlessness Mastery in Patients With Persistent Dyspnea NCT07173348 | University Hospital, Geneva | N/A |
| Not Yet Recruiting | Cervical Erector Spinae Plane Block for Dyspnea in Acute Respiratory Failure: A Prospective Cohort NCT07182695 | Hacettepe University | — |
| Not Yet Recruiting | Evaluation of the Effectiveness of the CardioStory Device in Distinguishing Heart Failure From Other Causes in NCT07147699 | Hôpital Universitaire Sahloul | — |
| Recruiting | Evaluation of the Impact of Pleuropulmonary Ultrasound on the Diagnosis of Dyspnea NCT07104578 | University Hospital, Toulouse | — |
| Not Yet Recruiting | Non-medicinal Technique and Dyspnea in Weaning Patients NCT06926231 | Hospices Civils de Lyon | N/A |
| Completed | Asymmetric High-Flow Nasal Cannula During Pulmonary Rehabilitation in COPD NCT07497230 | Universidad de Santiago de Chile | N/A |
| Completed | The Effect of Transcranial Direct Current Stimulation (tDCS) on Dyspnoea Perception, Pulmonary Function and Fu NCT06944626 | Okan University | N/A |
| Recruiting | Videoconferencing for the Management of Paediatric Dyspnoea in an Emergency Medical Call Centre NCT06847997 | Poitiers University Hospital | N/A |
| Not Yet Recruiting | Impact of Sarcopenia on Dyspnea in Patients With Asthma NCT06870890 | University Hospital, Clermont-Ferrand | N/A |
| Recruiting | Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients NCT06867354 | Assistance Publique - Hôpitaux de Paris | — |
| Recruiting | Effect of Fan Application in Preventing Ticagrelor-Associated Dyspnea NCT07268859 | Acibadem University | N/A |
| Completed | Dyspnea and Psychosocial Effects of Hand Fan Application in COPD Patients NCT06857422 | Ardahan University | N/A |
| Completed | "Turkish Validation of the Respiratory Distress Observation Scale in Palliative Care" NCT06922292 | Istinye University | — |
| Recruiting | Proof-of-concept Study on Dyspnea Analysis Via GapCO2 NCT06556797 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Alleviating Dyspnea With Non-Invasive Neuromodulation NCT06985628 | Université de Sherbrooke | N/A |
| Withdrawn | ExoFlo™ Infusion for Post-Acute COVID-19 and Chronic Post-COVID-19 Syndrome NCT05116761 | Direct Biologics, LLC | Phase 1 / Phase 2 |
| Recruiting | Cardiopulmonary Exercise Testing and Oscillometry for the Evaluation of Dyspnea NCT06554353 | University of Rochester | — |
| Recruiting | The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser) NCT06524856 | University of Nebraska | N/A |
| Withdrawn | The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease. NCT04181359 | University of Alberta | Phase 1 / Phase 2 |
| Not Yet Recruiting | Prevalence of EILO Among Children With Asthma NCT06480084 | Medisch Spectrum Twente | N/A |
| Completed | A Controlled Breathing Intervention to Reduce Stress and Improve Symptoms in COPD Patients (REST) NCT06404008 | University of Texas at Austin | N/A |
| Recruiting | Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention ( NCT06326957 | King's College Hospital NHS Trust | N/A |
| Completed | Additive Effects of 4-7-8 Breathing Technique With Standard Management on Dyspnea, Pulmonary Function and Qual NCT06966063 | Foundation University Islamabad | N/A |
| Recruiting | Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology NCT06336642 | M.D. Anderson Cancer Center | Phase 2 / Phase 3 |
| Completed | Dyspnea and Cerebral Cortex Activation Measured by fNIRS During Spontaneous Breathing Trial NCT06211738 | Assistance Publique - Hôpitaux de Paris | — |
| Suspended | Non-pharmacological Treatment of Dyspnea in Chronic Obstructive Pulmonary Disease (COPD) NCT04231058 | Azienda USL Toscana Nord Ovest | N/A |
| Recruiting | Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH NCT05937854 | VA Office of Research and Development | Phase 2 |
| Not Yet Recruiting | PAthwAy of Dyspneic patIent in Emergency in the North-east Region (North-East PArADIsE) NCT06235008 | Pr. Nicolas GIRERD | — |
| Recruiting | The Impact of Inhaled Furosemide and Perorally Administered Levodropropizine on Dyspnea in Patients With Respi NCT06252454 | University Hospital Hradec Kralove | Phase 2 / Phase 3 |
| Unknown | Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease NCT06229509 | University Hospital, Clermont-Ferrand | N/A |
| Recruiting | 129Xe MRI Cardiopulmonary NCT06038630 | Bastiaan Driehuys | Phase 2 |
| Recruiting | The Effect of Music Therapy on Dyspnea Severity and Vital Signs NCT06358235 | Suleyman Demirel University | N/A |
| Unknown | Effects of a Functional Re-education and Environmental Adaptation Programme in Cancer Patients With Associated NCT06035263 | University of Salamanca | N/A |
| Completed | Effectiveness of I COUGH Program to Dyspnea, Respiratory Parameters, Mobility and Pain After Major Abdominal S NCT06255327 | Yeditepe University | N/A |
| Completed | Home-Based Respiratory Muscle Strength Training Program for Individuals With Post-COVID-19 Persistent Dyspnea NCT06091280 | University of South Florida | N/A |
| Unknown | Diagnostic Performance of Chest Computed Tomography Scan in Patients Aged 65 and Over Presenting to Emergency NCT06104475 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functionin NCT06156202 | University of Pennsylvania | N/A |
| Terminated | Arterial Stiffness for Improved Prediction of Coronary Artery Disease by Coronary CT Angiography NCT06734247 | Danderyd Hospital | — |
| Completed | Virtual Reality at End-of-life NCT06149429 | State University of New York at Buffalo | N/A |
| Unknown | Two-year Efficacy of Three Exercise Rehabilitation Strategies on Dyspnea in Patients Who Presented With Second NCT05890560 | Fondation Hôpital Saint-Joseph | — |
| Completed | Improving Patient Prioritization During Hospital-homecare Transition NCT04136951 | Columbia University | N/A |
| Withdrawn | Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity NCT05812183 | University of California, Los Angeles | Phase 4 |
| Completed | A Wearable In-phase Chest Wall Vibration Device for Relief of Dyspnoea in COPD: a First-in-human Exploratory S NCT06432920 | Elevre Medical Ltd. | N/A |
| Recruiting | Diaphragmatic Function as a Biomarker NCT05903001 | RWTH Aachen University | — |
| Unknown | Neurobiological and Immunological Mechanisms of Dyspnea in ALS (BIOPNEA) NCT04332198 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Completed | Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Trainin NCT06165835 | Tri-Service General Hospital | N/A |
| Recruiting | Ventilation/Perfusion PET/CT With Galligas and 68Ga-MAA for Regional Lung Function Assessment After Pulmonary NCT05103670 | University Hospital, Brest | N/A |
| Completed | Evaluation of the Impact of Lung Ultrasound on Mortality and Rehospitalization in Patients Admitted to the Eme NCT05787665 | Hospices Civils de Lyon | — |
| Recruiting | Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection NCT05866952 | Tufts Medical Center | — |
| Unknown | Muscle Reflex Inhibition in Hypoxic Exercise NCT05619887 | University of British Columbia | N/A |
| Unknown | The Effect of Acupressure on the Management of Dyspnea NCT05884450 | Istanbul Aydın University | N/A |
| Completed | Autonomic Monitoring in Neurocardiogenic Syncope NCT05907018 | Children's Hospital Medical Center, Cincinnati | — |
| Unknown | Post-Coronavirus Disease of 2019 (COVID-19) Rehabilitation Clinics in Saudi Arabia NCT05799534 | Majmaah University | N/A |
| Completed | Walking Football for People With Chronic Breathlessness NCT05575102 | Teesside University | N/A |
| Recruiting | Added Diagnostic Value of Point of Care Ultrasound in Acute Dyspnea NCT05782478 | Region Skane | — |
| Completed | Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate Decline NCT05984186 | Vapotherm, Inc. | N/A |
| Unknown | Investigation of Arm Swings Characteristics in Patient With Chronic Obstructive Pulmonary Disease NCT05746702 | Hacettepe University | — |
| Unknown | Value of Transthoracic Ultrasonography (TTU) for Etiological Diagnosis of Acute Dyspnea: Cross Sectional Study NCT05647655 | Assiut University | — |
| Unknown | POCUS VS CT in Diagnosis of Acute Dyspnea in Chronic Hemodialysis Patients NCT05729035 | Randa Ahmed Sarhan | — |
| Unknown | Effect of Breathing Exercises and Upper Limb Endurance Exercises in Pregnant Women Presented With Physiologica NCT05710003 | Entsar Hsanen | N/A |
| Completed | Point-Of-Care Ultrasound-Driven vs Standard Diagnostic Pathway in Emergency Department Patients With Dyspnea NCT05674916 | Aarhus University Hospital | N/A |
| Unknown | Improving Quality of Life and Daily Life Activities With Bioarginine in Patients With COPD NCT05412160 | University of Milan | N/A |
| Recruiting | Menthol for Dyspnea Relief in Health and COPD NCT05785026 | KU Leuven | N/A |
| Completed | Effect of Progressive Relaxation Exercıses on Dyspnea and Comfort Level in Individuals With COPD NCT06459882 | Izmir Bakircay University | N/A |
| Recruiting | Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and Adolescents NCT06201494 | Charles University, Czech Republic | — |
| Completed | Effect of Diuretics Withdrawal in Chronic Heart Failure With Reduced Ejection Fraction NCT05964738 | Maimónides Biomedical Research Institute of Córdoba | Phase 2 |
| Active Not Recruiting | Breathlessness Relieved by Employing Medical Air to be Titrated by Hospitalized Patients to Improve Inpatient NCT05416437 | Ohio State University | N/A |
| Withdrawn | Effects of Wearing a Face Mask During CrossFit Exercise NCT04688502 | University of Saskatchewan | N/A |
| Unknown | TaiChi-DTx for Treating Long Covid Symptoms NCT05419219 | Tim Shi | N/A |
| Completed | Short Term Results of Tele-Rehabilitation NCT05381675 | Harran University | N/A |
| Completed | KINO-DYSPNEA: Validation of Kinocardiography to Distinguish Dyspnea of Cardiac Origin From Others NCT06008600 | Centre Hospitalier Universitaire de Tivoli | — |
| Terminated | Clinician Assessment of Patient Dyspnea NCT05319379 | Rush University Medical Center | — |
| Terminated | Post-Acute Sequelae of Coronavirus-19 (COVID-19) With Dyspnea on Exertion And Associated TaChycardia TrEatment NCT05096884 | Hackensack Meridian Health | EARLY_Phase 1 |
| Withdrawn | Sentinel - Triaging Acute Breathlessness Using Multi-Modal Biomarkers NCT05304494 | Sanome | — |
| Unknown | Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound NCT05352490 | University of Monastir | — |
| Completed | Evaluation of Treatment With Viusid in Post-COVID-19 Syndrome NCT06437210 | Catalysis SL | N/A |
| Unknown | Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals. NCT05623696 | Oxford Brookes University | N/A |
| Completed | The Effectiveness Pulmonary Telerehabilitation and Cognitive Telerehabilitation in COPD Patients NCT05222295 | Saglik Bilimleri Universitesi | N/A |
| Completed | The Effects of a Music Therapy Respiratory Protocol on Post-Covid-19 Respiratory Symptoms NCT05231512 | Icahn School of Medicine at Mount Sinai | N/A |
| Terminated | Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Device Equivalence NCT04590014 | Vapotherm, Inc. | N/A |
| Withdrawn | Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19 NCT05137795 | APR Applied Pharma Research s.a. | Phase 3 |
| Unknown | Prevalence of Rest Dyspnea and Impact of Non Invasive Ventilation on Breathing Sensations in CCHS Patients NCT04447196 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | — |
| Completed | Validation of PMcardio AI-assisted Clinical Assistant in Primary Care NCT05329246 | Powerful Medical | N/A |
| Unknown | Artificial Intelligence to Improve Physicians' Interpretation of Chest X-Rays in Breathless Patients NCT05117320 | Bispebjerg Hospital | N/A |
| Completed | Venous Versus Arterial Blood Gas Sampling in Undifferentiated Emergency Patients NCT04409470 | University Hospital, Linkoeping | — |
| Unknown | Dyspnea Neuroscience Education on Patients With Chronic Obstructive Pulmonary Disease NCT04987125 | Cardenal Herrera University | N/A |
| Completed | Hypnosis for the Management of Anxiety and Breathlessness During a Pulmonary Rehabilitation Program NCT04868357 | Centre Hospitalier de Bligny | N/A |
| Completed | Preventing Dyspnea During Speech in Older Speakers NCT05029986 | University of Delaware | N/A |
| Active Not Recruiting | Improving Diagnostic Accuracy for Acute Heart Failure NCT04886128 | Vanderbilt University Medical Center | — |
| Unknown | Ventilation Imbalances in Mild to Moderate Chronic Obstructive Pulmonary Disease NCT04880551 | Oregon Health and Science University | — |
| Completed | Radiofrequency in Patients Post Covid 19 With Respiratory Sequelae. NCT07184372 | Clinica Gema Leon | N/A |
| Unknown | The Effectiveness of Respiratory Tele-rehabilitation After COVID-19 Pneumonia Related: a Randomized Controlled NCT05007457 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Completed | Inhaled Nitric Oxide (iNO) in Post-Pulmonary Embolism (Post-PE) NCT04920695 | Dr. Denis O'Donnell | N/A |
| Unknown | Effects of a Specific Programme for the Recovery of Autonomy Plus Multimodal Physical Exercise in Oncology Pat NCT04766593 | University of Salamanca | N/A |
| Unknown | Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation NCT04859894 | Linkoeping University | — |
| Terminated | Dyspnea and Cardiotoxicity in Multiple Myeloma Patients Who Receive Carfilzomib NCT04827563 | University of Chicago | — |
| Completed | Establishing Clinical Utility for a New Diagnostic Test for Patients With Shortness of Breath NCT04693793 | Qure Healthcare, LLC | N/A |
| Completed | Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19 NCT04732663 | University of Alberta | — |
| Terminated | Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19 NCT04360096 | APR Applied Pharma Research s.a. | Phase 2 / Phase 3 |
| Withdrawn | Fatigue in Patients With Amyotrophic Lateral Sclerosis NCT04468191 | Cara Donohue | N/A |
| Completed | SELF-BREATHE RCT for Chronic Breathlessness NCT04574050 | King's College Hospital NHS Trust | N/A |
| Completed | Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest NCT04170062 | Johns Hopkins University | N/A |
| Recruiting | Feasibility and Accuracy of an Ultrasound Algorithm for Acute Dyspnea Diagnosis in the Emergency Department NCT03691857 | CHOUIHED Tahar | N/A |
| Completed | Virtual Reality Intervention Alleviates Dyspnea in Patients Recovering From COVID Pneumonia NCT04844567 | Ecole Polytechnique Fédérale de Lausanne | N/A |
| Completed | Clinical Stabilization of Hypercapnia: NIPPV v HVNI NCT04709562 | Vapotherm, Inc. | N/A |
| Completed | Effectiveness of Volume Spirometry and Deep Breathing Exercise for Dyspnea During Third Trimester of Pregnancy NCT04994028 | Riphah International University | N/A |
| Completed | Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs NCT04512781 | Vapotherm, Inc. | N/A |
| Active Not Recruiting | Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF NCT04688905 | University of Leipzig | — |
| Recruiting | Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine NCT04615065 | University Medical Center Groningen | — |
| Completed | The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)" NCT04305639 | Istanbul Medeniyet University | — |
| Completed | Effectiveness of an Exercise Re-training Program on Dyspnea in Patients After Acute Respiratory Distress Syndr NCT04569266 | Fondation Hôpital Saint-Joseph | N/A |
| Completed | Prospective Study of Persistent Dyspnea in Recovered COVID-19 Patients NCT04689490 | Hospital Clínico Universitario de Valladolid | — |
| Completed | Dyspnea in Stable Patients With Coronary Artery Disease. NCT04408612 | National Research Center for Preventive Medicine | — |
| Completed | Patient Dyspnea Under Veno-arterial Extracorporeal Circulation NCT04815330 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | — |
| Completed | International SARS-CoV-2 (COVID-19) Infection Observational Study NCT04385251 | University of Minnesota | — |
| Completed | Follow-up of Respiratory Sequelae of Hospitalized Patients With COVID-19 NCT04505631 | Groupe Hospitalier de la Region de Mulhouse et Sud Alsace | — |
| Completed | SELF - BREATHE for Chronic Breathlessness NCT04466020 | King's College Hospital NHS Trust | — |
| Completed | Feasibility and Functionality Test of Ada's DDSS Prototype NCT04827342 | University Hospital, Basel, Switzerland | — |
| Completed | Knowledge, Attitude and Practice of Dental Students About COVID-19 NCT04449081 | Melaka Manipal Medical College | — |
| Withdrawn | Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection NCT04290858 | Xijing Hospital | Phase 2 |
| Completed | Hydrogen/Oxygen Mixed Gas Inhalation for Coronavirus Disease 2019 (COVID-19) NCT04378712 | Guangzhou Institute of Respiratory Disease | N/A |
| Completed | Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis NCT04236934 | Naestved Hospital | — |
| Completed | Blue Protocol Assessment NCT04223297 | Centre Hospitalier Universitaire, Amiens | — |
| Completed | Sensory and Emotional Modulation of Dyspnea Under Artificial Ventilation in the Intensive Care Unit NCT04815317 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Terminated | Assessment of Pulmonary Congestion During Cardiac Hemodynamic Stress Testing NCT04019613 | Mayo Clinic | N/A |
| Completed | Value of Diaphragmatic Motion Measurement at Ultrasonography to Predict Poor Prognosis in Emergency Department NCT04119505 | University Hospital, Montpellier | — |
| Completed | Monitoring Patients With Shortness of Breath With Repeated Ultrasound Examinations NCT04091334 | Slagelse Hospital | N/A |
| Completed | Mobile-Application Based Respiratory Rehabilitation For COPD NCT05890443 | Ordu University | N/A |
| Completed | Effects of Menthol on Dyspnoea in COPD Patients NCT03626519 | Groupe Hospitalier du Havre | N/A |
| Unknown | Point-of-care Ultrasound Interest in Dyspneic Emergency Department Patients: an Observational Bicentric Study NCT04327882 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Is Reduced Hypoxia Through a Robot Intervention, Associated With Sensory and Emotional Descriptions of Dyspnea NCT04375917 | Copenhagen University Hospital, Hvidovre | N/A |
| Completed | Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD NCT04370990 | Copenhagen University Hospital, Hvidovre | N/A |
| Completed | Deventilation Dyspnea in COPD Patients Using NIV NCT03503123 | University Medical Center Groningen | — |
| Unknown | Effects of Transcutaneous Nerve Electrostimulation (TENS) of Acupuncture Points on Pulmonary Function and Dysp NCT04051398 | Hospital Santa Marcelina | N/A |
| Unknown | Delirium, Agitation/Sedation, Pain and Dyspnea in Respiratory Intensive Care Unit (NIVILIUM) NCT03880084 | University of Modena and Reggio Emilia | — |
| Completed | Interdisciplinary Approach for Refractory Dyspnoea NCT04015817 | Ligue Pulmonaire Neuchâteloise | N/A |
| Terminated | Influence of an Inverse Pressure Ramp in Long-term Non-invasive Ventilation on Dyspnea in the Morning After Th NCT04093427 | Wissenschaftliches Institut Bethanien e.V | N/A |
| Completed | Improving Safety of Diagnosis and Therapy in the Inpatient Setting NCT04393909 | Brigham and Women's Hospital | N/A |
| Completed | Point-of-care Ultrasound in Prehospital Dyspnea NCT03905460 | University of Aarhus | — |
| Unknown | Prevalence and Characterization of Persistent Dyspnea After Hospitalization NCT03798158 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | — |
| Recruiting | Effects of a Pulmonary and Cardiovascular Rehabilitation Program NCT06772922 | University of Campinas, Brazil | N/A |
| Completed | Individualized Plan for Improving Adherence to Portable Oxygen Therapy in Patients With Respiratory Pathology NCT04691336 | Air Liquide Healthcare Spain | N/A |
| Terminated | Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance NCT05267418 | Laval University | N/A |
| Completed | Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced NCT04630743 | University of Cologne | N/A |
| Terminated | The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams NCT03214809 | Rijnstate Hospital | N/A |
| Completed | Symptom-related Screening for Early Detection of CTEPH. NCT03953560 | Luis Jara-Palomares, MD | N/A |
| Completed | Emergency Classification According to Fingertip Circulation NCT05742113 | Manisa Celal Bayar University | N/A |
| Unknown | Nursing Care for Breathing Discomfort Among Mechanically Ventilated Patients NCT04019236 | Assiut University | N/A |
| Completed | HVNI Ambulation Feasibility Study NCT03885726 | Vapotherm, Inc. | N/A |
| Unknown | Randomized Study Evaluating the Efficacy of Low Intensity Transcranial Electrical Stimulation (Tdcs) for the R NCT03640455 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Unknown | The Safety and Efficacy of FFR Protocol in NTUH System NCT03693157 | National Taiwan University Hospital Hsin-Chu Branch | — |
| Unknown | Effects of P2Y12 Receptor Inhibitors on Central and Peripheral Chemoreceptors' Sensitivity NCT05080478 | Wroclaw Medical University | — |
| Unknown | Education and Training Competences in Thoracic Ultrasound NCT03728491 | Odense University Hospital | N/A |
| Completed | The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD NCT03679312 | University of Alberta | Phase 1 / Phase 2 |
| Completed | Efficacy and Mechanism of NIV in Relieving Dyspnea After Exercise in Patients With Stable Severe COPD NCT03568747 | Guangzhou Institute of Respiratory Disease | N/A |
| Withdrawn | Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot NCT03653104 | VA Quality Enhancement Research Intiative | N/A |
| Completed | Effects on Experimental Dyspnea of High Flow Nasal Cannula NCT03469037 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Completed | The Relating Experienced To Recalled Breathlessness Observational Study NCT03468205 | Skane University Hospital | — |
| Completed | Validity and Reliability of The Turkish Version of Breathlessness Beliefs Questionnaire NCT03517826 | Bezmialem Vakif University | — |
| Completed | Wireless Assessment of Respiratory and Circulatory Distress in Chronic Obstructive Pulmonary Disease NCT03467815 | Bispebjerg Hospital | — |
| Completed | Breathlessness During Exercise: Experience and Memory NCT03458182 | Magnus Ekström | N/A |
| Completed | Spinal Structure and Mobility in Chronic Obstructive Pulmonary Disease NCT05021068 | Izmir Katip Celebi University | — |
| Completed | High-flow Nasal Oxygen in Palliative Care: Pilot Study NCT03423888 | University Hospital, Toulouse | N/A |
| Active Not Recruiting | Dexamethasone in Controlling Dyspnea in Patients With Cancer NCT03367156 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | Vitabreath Pilot in Chronic Obstructive Pulmonary Disease (COPD) Patients NCT03349437 | Philips Respironics | N/A |
| Unknown | Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS NCT03604822 | Alisa Apreleva | N/A |
| Unknown | Cycle-ergometer in the Postoperative of Thoracic Surgery NCT03229070 | Federal University of Health Science of Porto Alegre | N/A |
| Completed | Pulmonary Rehabilitation, Dyspnoea and Emotional Cognition in COPD NCT03092700 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | — |
| Unknown | Incentive Spirometry in Non-critically Ill Hospitalized Patients With Acute Respiratory Failure NCT02873000 | Jewish Hospital, Cincinnati, Ohio | N/A |
| Completed | Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF) NCT03831204 | University of Monastir | — |
| Unknown | Efficacy of Inspiratory Muscle Training on Elite Swimmers NCT03062735 | Universidade do Porto | N/A |
| Terminated | Palliation of Dyspnea With Mouth Piece Ventilation in AECOPD NCT03025425 | Tampere University Hospital | N/A |
| Terminated | Palliation of Dyspnea With Mouth Piece Ventilation NCT03012737 | Tampere University Hospital | N/A |
| Completed | EMPOWER-PULM (PULMonary Outcomes in Older Adults Empowered With Movement to Prevent Obesity and Weight Regain) NCT03621098 | Wake Forest University Health Sciences | — |
| Completed | Progressive Relaxation Exercises in COPD NCT04559503 | Nigde Omer Halisdemir University | N/A |
| Unknown | Multisystem Shortness of Breath Evaluation Study NCT03276507 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | — |
| Terminated | Diagnostic Reasoning and Sense of Alarm at Dyspnoea and / or Chest Pain NCT02932982 | University Hospital, Brest | — |
| Completed | Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath NCT02638649 | Yale University | — |
| Completed | Breathlessness Exertion and Morphine Sulphate NCT02720822 | Flinders University | Phase 3 |
| Completed | Evaluating the Effectiveness of Incentive Spirometry NCT02952027 | Lifespan | N/A |
| Completed | Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Depart NCT02861508 | Yale University | N/A |
| Completed | AFrican Resuscitation Ultrasound In Critically-ill Adults NCT02794909 | Rockefeller Oteng | N/A |
| Completed | Effect of Hypnosis on Dyspnea NCT02792738 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Unknown | Hospital Without Dyspnea. Rationale and Design of a Multidisciplinary Intervention NCT02538289 | Hospital General Universitario Gregorio Marañon | N/A |
| Terminated | Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application NCT02758990 | Verifomics LLC | N/A |
| Completed | Impact of Proportional Assisted Ventilation on Dyspnea and Asynchrony in Mechanically Ventilated Patients NCT02801994 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Completed | Validation of an Observational Scale of Dyspnea in Non-communicating Patients in the ICU NCT02801838 | Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil | N/A |
| Completed | Emergency Department Cardiac Ultrasound NCT02719509 | Hennepin Healthcare Research Institute | — |
| Completed | Focus Thoracic Ultrasound for Dyspnea Diagnosis in Elderly Patient in the Emergency Department NCT04029051 | Nantes University Hospital | — |
| Completed | Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease NCT02622022 | University of Aarhus | Phase 4 |
| Completed | Impact of Dyspnea on Patients in the Intensive Care Unit NCT02336464 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Feasibility Testing of a Hospice Family Caregiver Intervention to Improve Patient Dyspnea Care NCT02441868 | Wayne State University | N/A |
| Completed | The Use of Intranasal Fentanyl for the Treatment of Incident Dyspnea in Congestive Heart Failure: A Prospectiv NCT02454751 | St. Boniface Hospital | Phase 2 |
| Completed | Specificity of Dyspnoea Relief With Inhaled Furosemide NCT02881866 | Oxford Brookes University | Phase 1 |
| Completed | Study of an Integral Respiratory Rehabilitation Program in Oncological Patient With Disney NCT04186754 | University of Salamanca | N/A |
| Completed | Comparison of Three Scores for Ultrasound Assessment and Monitoring of Pulmonary Aeration NCT02450825 | Centre hospitalier de l'Université de Montréal (CHUM) | N/A |
| Completed | PERCEPIC: PERC Rule Combined With Implicit Low Clinical Probability NCT02360540 | University Hospital, Angers | — |
| Withdrawn | Opioids for Refractory Breathlessness in Chronic Obstructive Pulmonary Disease NCT02455362 | Flinders University | Phase 3 |
| Completed | Evaluation of Transient Dyspnea During Gadoxetic Acid Enhanced Multiphasic Liver MRI NCT02395991 | Seoul National University Hospital | — |
| Unknown | High-Flow Oxygen in Reducing Shortness of Breath Caused by Exercise in Patients With Cancer NCT02357134 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | Aromatherapy and Essential Oils in Improving Insomnia and Other Symptoms in Patients With Newly Diagnosed Acut NCT02445378 | Ohio State University Comprehensive Cancer Center | N/A |
| Terminated | Trial of Caffeine to Alleviate Dyspnea Related to Ticagrelor NCT02311088 | Uppsala University | Phase 2 |
| Completed | Aerosol Inhalation Treatment for Dyspnea - Patients NCT02524054 | Beth Israel Deaconess Medical Center | Phase 1 / Phase 2 |
| Completed | Diaphragmatic Paralysis in Arthroscopic Shoulder Surgery NCT03192865 | Clinique Medipole Garonne | — |
| Completed | Making Sense of Dyspnea Assessment NCT02771262 | NYU Langone Health | — |
| Completed | Evaluation of Cardiopulmonary Diseases by Ultrasound NCT02248831 | Echosense Ltd. | N/A |
| Terminated | Chest Ultrasound of ER Patients With Cough or SOB NCT02269761 | University of Washington | — |
| Completed | Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization NCT02538770 | University of Oulu | N/A |
| Completed | Mind-Body Walking Exercise for Chronic Obstructive Pulmonary Disease NCT03388489 | National Taiwan University Hospital | N/A |
| Withdrawn | Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF NCT04592380 | The Medicines Company | Phase 3 |
| Completed | Precision of IMED-4 Lung Fluid Measurements NCT02187770 | Intersection Medical, Inc. | — |
| Completed | Utility of Lung Clearance Index Score as a Noninvasive Marker of Deployment Lung Disease NCT03012958 | National Jewish Health | — |
| Completed | Fluid Status of Outpatients With Dyspnea NCT02111525 | Intersection Medical, Inc. | — |
| Terminated | Treatment of Dyspnea in Do-not-intubate Patients NCT02114944 | Tufts Medical Center | — |
| Terminated | Diagnostic Value of Portable Ultrasound for Dyspneic Patient Support in the Emergency Department NCT01818882 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Completed | Dyspnea in COPD: Relationship With Exacerbations Frequency NCT02113839 | Hospital Clinic of Barcelona | N/A |
| Completed | Acupuncture Feasibility Trial for Dyspnea in Lung Cancer NCT02094950 | Abramson Cancer Center at Penn Medicine | Phase 1 |
| Completed | European Dyspnoea Survey in the EMergency Departments NCT02060799 | Hopital Lariboisière | — |
| Completed | Prehospital Triage of Patients With Severe Shortness of Breath Using Biomarkers NCT02050282 | University of Aarhus | N/A |
| Completed | Respiratory Complaints Checklist Trial NCT02283892 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Abdominal Binding in Chronic Obstructive Pulmonary Disease NCT01852006 | McGill University | N/A |
| Completed | Comparison Between Lung Ultrasound and Chest Radiography for Acute Dyspnea NCT02105207 | University of Turin, Italy | N/A |
| Completed | Effect of Non Invasive Brain Stimulation on Experimentally Induced Dyspnea (Breathlessness) NCT01892553 | Centre d'Investigation Clinique et Technologique 805 | N/A |
| Completed | Improving Management of Breathlessness in Patients With Lung Cancer NCT01937637 | Massachusetts General Hospital | N/A |
| Terminated | The Triple A Initiative Study ("Aktionsbündnis Akute Atemnot") NCT02049853 | Prof. Dr. Michael Christ | N/A |
| Completed | Inhaled Ondansetron & Dyspnea NCT01851993 | McGill University | EARLY_Phase 1 |
| Completed | Inhaled Fentanyl Citrate & Dyspnea NCT01853449 | McGill University | EARLY_Phase 1 |
| Completed | Lisinopril in Reducing Shortness of Breath Caused by Radiation Therapy in Patients With Lung Cancer NCT01880528 | Mayo Clinic | Phase 2 |
| Completed | Arterial pH Selectively Predicts Intensive Care Unit Transfer From the Emergency Department in Obese Patients NCT03239730 | Association pour la Formation du Personnel à la Medecine d'Urgence | — |
| Completed | Registry of Patients With Acute Dyspnea in the Emergency Department NCT01910233 | Klinikum Nürnberg | — |
| Completed | A Randomized Multicentre Trial to Evaluate the Utilization of Revascularization or Optimal Medical Therapy for NCT01760083 | Euro CTO Club | N/A |
| Withdrawn | Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patie NCT01687751 | Fraser Health | Phase 2 |
| Completed | Systolic Time Intervals in the Diagnosis of Heart Failure in Emergency Departement NCT02161445 | University of Monastir | — |
| Completed | Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure NCT01644331 | Duke University | Phase 3 |
| Unknown | Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chron NCT01655199 | Laval University | N/A |
| Completed | Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Drug NCT01841515 | University of Ulsan | Phase 1 |
| Terminated | Assessment of The Clinical Course of Dyspnea in Acute Heart Failure Patients NCT01615926 | Northwestern University | — |
| Completed | Database of All Patients Who Have Undergone Pulmonary Function Testing at Singapore General Hospital NCT01601288 | Singapore General Hospital | — |
| Completed | Breakthrough Dyspnea Fentanyl Study in Cancer Patients NCT01515566 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Completed | Improving Care of Patients With Heart Failure NCT01461681 | University of California, San Francisco | N/A |
| Terminated | Diaphragmatic Breathing Retraining in Heart Failure Patients: Health-Behavior Related Outcomes NCT01478932 | University of Nebraska | N/A |
| Completed | Chest CT-scan for the Diagnosis of Community-acquired Pneumonia NCT01574066 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | STRETCH OF RESPIRATORY MUSCLES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE NCT02036762 | University of Sao Paulo | Phase 2 / Phase 3 |
| Completed | BRIPPED Scan for Evaluation of Emergency Department (ED) Patients With Shortness of Breath NCT01662843 | Eastern Virginia Medical School | — |
| Completed | Non Opioid Treatment for Experimental Dyspnea NCT01577407 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Aerosol Inhalation Treatment for Dyspnea NCT01440764 | Beth Israel Deaconess Medical Center | Phase 1 / Phase 2 |
| Completed | Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease NCT01418248 | Mayo Clinic | — |
| Completed | Inspiratory Muscle Training in Stroke Patients With Stable Congestive Heart Failure: a Prospective RCT. NCT02614001 | Chang Gung Memorial Hospital | N/A |
| Completed | Effect of Indacaterol Maleate in Chronic Obstructive Pulmonary Disease (COPD) on Lung Volume and Related Dyspn NCT01377051 | University of Milan | Phase 4 |
| Completed | Influence of Routinely Adding Ultrasound Screening in Medical Department NCT01331187 | Helse Nord-Trøndelag HF | N/A |
| Completed | Ranolazine in Ischemic Cardiomyopathy NCT01345188 | Midwest Cardiovascular Research Foundation | Phase 4 |
| Completed | Device-guided Breathing for Shortness of Breath in COPD NCT01286181 | Mayo Clinic | N/A |
| Unknown | Study of a Tiotropium Inhaler For Shortness of Breath in Advanced Non-Small Cell Lung Cancer NCT01172925 | Hamilton Health Sciences Corporation | Phase 2 |
| Completed | Combined Use of Respiratory Devices After Thoracic Surgery NCT01510275 | Villa Pineta Hospital | N/A |
| Completed | Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea NCT01197586 | Universitätsmedizin Mannheim | — |
| Completed | Lung Ultrasound for Acute Dyspnea in Emergency Department NCT01287429 | University of Turin, Italy | — |
| Completed | Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department NCT01193998 | Unity Health Toronto | N/A |
| Unknown | Vibration Response Imaging (VRI) in Dyspnea Patients Presenting to the ED NCT01206621 | Deep Breeze | — |
| Unknown | Muscle Training Effectiveness in the Degree of Dyspnea and Aerobic Capacity in COPD NCT01452932 | CES University | Phase 1 / Phase 2 |
| Terminated | Effectiveness of Inhaled Corticosteroids in Preschool Children With Acute Dyspnea and Wheeze NCT00962299 | Princess Amalia Children's Clinic | Phase 4 |
| Completed | Screening of Patients Admitted to a Local Hospital With Pocket-sized Ultrasound NCT01081210 | Helse Nord-Trøndelag HF | — |
| Completed | The Impact of Udenafil on Exercise Capacity in Severe Chronic Obstructive Pulmonary Disease (COPD) Patients NCT01364181 | Seoul National University Hospital | Phase 3 |
| Completed | Study of Episodic Breathlessness in Patients With Lung Cancer or Other Advanced Disease NCT01138358 | King's College Hospital NHS Trust | — |
| Completed | The Use of a Handheld Fan to Manage Breathlessness - A Feasibility Study NCT00974558 | Cambridge University Hospitals NHS Foundation Trust | N/A |
| Unknown | The Incidence of TRALI in Patients Undergoing Orthopedic-Oncology Surgery NCT00914784 | Tel-Aviv Sourasky Medical Center | — |
| Unknown | Stress Ventricular Function in Evaluating Patients With Pulmonary Hypertension NCT02647034 | National Taiwan University Hospital | — |
| Completed | Utility of the History and Physical Exam in the Emergency Department NCT01154517 | Henry Ford Health System | — |
| Unknown | Study of How Caregivers Help Patients Cope With Respiratory and Other Symptoms Caused by Lung Cancer NCT00979888 | University of Manchester | N/A |
| Unknown | Diagnostic and Prognostic Value of New Biomarkers in Patients With Heart Disease NCT01374880 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Completed | Pulmonary Function Test, Bronchial Hyperresponsiveness and Quality of Life in Patients With Vocal Cord Dysfunc NCT00906867 | Johann Wolfgang Goethe University Hospital | — |
| Unknown | Study of Electrical Bioimpedance in Heart Failure. NCT00843245 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Withdrawn | Losartan in Treating Pulmonary Fibrosis in Patients With Stage I, II, or III Non-Small Cell Lung Cancer NCT00880386 | University of South Florida | N/A |
| Completed | Bedside Ultrasound Identifies Congestive Heart Failure NCT00833144 | Emory University | — |
| Unknown | Trial of a Breathlessness Intervention Service for Intractable Breathlessness NCT00678405 | Cambridge University Hospitals NHS Foundation Trust | Phase 3 |
| Completed | Heliox in Experimental Upper Airway Obstruction NCT00788788 | University of Witten/Herdecke | Phase 1 / Phase 2 |
| Withdrawn | Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal NCT00505791 | University of Medicine and Dentistry of New Jersey | Phase 4 |
| Completed | Correlation Research Study: IQ2, NcIQ and IQ101 NCT00491777 | Noninvasive Medical Technologies, Inc. | Phase 1 |
| Completed | Pilot Randomized Controlled Trial of a Breathlessness Intervention Service for Chronic Obstructive Pulmonary D NCT00711438 | Cambridge University Hospitals NHS Foundation Trust | Phase 2 |
| Completed | "Red Morphine Drops" for Symptomatic Treatment of Dyspnoea in Lung Cancer NCT00338481 | Sankt Lukas Hospice | Phase 4 |
| Active Not Recruiting | Basics in Acute Shortness of Breath EvaLuation (BASEL V) Study NCT01831115 | University Hospital, Basel, Switzerland | — |
| Completed | Intervention to Improve Care at Life's End NCT00234286 | US Department of Veterans Affairs | N/A |
| Completed | NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema NCT00143793 | Universitätsmedizin Mannheim | — |
| Completed | Palliative Oxygen for the Relief of Breathlessness NCT00327873 | National Health and Medical Research Council, Australia | N/A |
| Completed | Dyspnea and Biomarkers in a Prehospital Setting NCT00878475 | Community Healthcare Center dr. Adolf Drolc Maribor (HCM) | — |
| Completed | NT-proBNP in Acute Dyspnea: Effects on Treatment, Hospitalisation and Costs NCT00410293 | Erasmus Medical Center | N/A |
| Completed | Continuous Positive Airway Pressure for Acute Pulmonary Edema NCT00554580 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | B-type Natriuretic Peptide for Acute Shortness of Breath EvaLuation (BASEL) Study - Private Practice NCT00130611 | University Hospital, Basel, Switzerland | Phase 4 |
| Completed | FAST (Fluid Accumulation Status Trial) NCT00289276 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Unknown | Evaluation of Spirometry Expert Support in General Practice NCT00131157 | Radboud University Medical Center | N/A |
| Completed | Buspirone in Reducing Shortness of Breath in Patients With Cancer NCT00053846 | University of Rochester | Phase 2 / Phase 3 |
| Completed | The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure NCT00043836 | Synvista Therapeutics, Inc | Phase 2 |
| Completed | Evaluation of Breathing Pattern and Dyspnea in Subjects With Tetraplegia NCT00904436 | US Department of Veterans Affairs | N/A |