NCT01418248

Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease

Evaluation of Exercise Intolerance and Right Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 108 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise Testing (CPX) as compared with gold standard invasive hemodynamic assessment.

Detailed description

* The broad objective of this proposal is to characterize the dynamic changes in cardiopulmonary mechanics during stress in patients with exertional dyspnea, establishing a comprehensive multimodality diagnostic approach to the evaluation of exercise intolerance. * The specific objective is to prospectively compare established and novel parameters derived from echocardiography and CPX with simultaneous, gold standard invasive measures of cardiovascular hemodynamics at rest and with exercise stress to define the role of noninvasive testing in the diagnostic workup. * The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.

Conditions

• Exercise Tolerance
• Dyspnea
• Heart Failure
• Pulmonary Hypertension

Timeline

• Start date: 2011-08-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2011-08-17
• Last updated: 2014-01-09

Locations

1 site across 1 country: United States