Trials / Active Not Recruiting
Active Not RecruitingNCT04688905
Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
Diagnosestellung Der Herzinsuffizienz Mit Erhaltener Ejektionsfraktion Bei Patienten Mit Unklarer Belastungsdyspnoe - Validierung Gegen Den Invasiven Goldstandard (Diagnose-HFpEF)
- Status
- Active Not Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 30 (actual)
- Sponsor
- University of Leipzig · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
Invasive diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with unexplained dyspnea NYHA II-III compared to other diagnostic tools
Detailed description
Multiple diagnostic tests, including stress tests and the invasive conduction of left ventricular pressure-volume loops via conductance catheter (as gold standard) will be performed in patients with unexplained dyspnea NYHA II-III in order to identify patients with a heart failure with preserved ejection fraction (HFpEF). The results will be compared to previously reported diagnostic scores such as the H2FPEF and the HFA-PEFF score.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Invasive hemodynamics of left ventricle via conductance catheter at rest, with exercise and with temporary vena cava occlusion | Invasive hemodynamics of left ventricle will be done by the conductance method. Left ventricular stiffness constant will be obtained by temporary vena cava occlusion. Right heart catherization will be done by pulmonary artery catherization and cardiac output will be estimated by thermodilution and Fick´s method. |
Timeline
- Start date
- 2020-09-09
- Primary completion
- 2023-08-04
- Completion
- 2026-08-30
- First posted
- 2020-12-30
- Last updated
- 2025-11-19
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT04688905. Inclusion in this directory is not an endorsement.