NCT05907018

Autonomic Monitoring in Neurocardiogenic Syncope

Comparing Phenotypic and Autonomic Physiologic Determinants of Neurocardiogenic Syncope

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Children's Hospital Medical Center, Cincinnati · Academic / Other
• Sex: All
• Age: 7 Years – 24 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective observational pilot study of suitability of autonomic monitoring via the VU-AMS device for prediction of neurocardiogenic syncope (NCS) in children referred to cardiopulmonary exercise testing (CPET) for a diagnosis of syncope. The study population is children referred for CPET to evaluate for neurocardiogenic syncope. The purpose is to describe autonomic function during rest and exercise and determine the positive predictive value of autonomic function measurements against the gold standard for diagnosis of neurocardiogenic syncope, the CPET. Children presenting for CPET with chest pain or who are status post orthotopic heart transplantation will serve as positive and negative controls respectively.

Conditions

• Syncope
• Chest Pain
• Dyspnea

Timeline

• Start date: 2023-05-12
• Primary completion: 2024-10-23
• Completion: 2024-10-23
• First posted: 2023-06-18
• Last updated: 2025-01-29

Locations

1 site across 1 country: United States