| Not Yet Recruiting | Canadian Prehospital Syncope Risk Score (Prehospital CSRS) NCT05560126 | Venkatesh Thiruganasambandamoorthy | — |
| Active Not Recruiting | Pediatric Adhesion and New Dermal Approach Study NCT07118124 | iRhythm Technologies, Inc. | N/A |
| Recruiting | AVEIR™ Leadless Pacemaker (LP) United Kingdom (UK) Registry NCT06854484 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Recruiting | Do QT-Prolonging Drugs Cause Major Adverse Cardiac Events in Hospitalized Adults? NCT07374263 | St. Joseph's Healthcare Hamilton | — |
| Recruiting | AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor NCT06699056 | Peerbridge Health, Inc | — |
| Enrolling By Invitation | COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Usi NCT06763549 | Peerbridge Health, Inc | — |
| Recruiting | Comparison of the Efficacy and Safety of Cardioneuroablation to Permanent Pacing in Patients With an Implanted NCT05896592 | 4th Military Clinical Hospital with Polyclinic, Poland | N/A |
| Active Not Recruiting | Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC) NCT06526884 | University of California, Los Angeles | N/A |
| Recruiting | Remote Symptom Review in Patients With Implantable Diagnostic Holter NCT06431828 | Andres Iñiguez Romo | N/A |
| Completed | Assessment of the Mechanism of Non-cardiac Syncope NCT05728255 | Istituto Auxologico Italiano | — |
| Active Not Recruiting | Creation of a Syncope Channel for Patients Admitted to the Emergency Department for Loss of Consciousness and NCT06503653 | Versailles Hospital | N/A |
| Recruiting | Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT Study NCT06356207 | Azienda Ospedaliera di Bolzano | — |
| Recruiting | Cardioneuroablation for Bradyarrhythmia NCT06288633 | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | N/A |
| Recruiting | The Z Stitch Early Bed Rest Assessment Study NCT06087497 | Oregon Health and Science University | N/A |
| Completed | Using Mirabegron to Increase BP in Patients With POTS NCT06133075 | Cedars-Sinai Medical Center | Phase 2 |
| Recruiting | In Hospital 24 Hour Observation of Syncope Patients NCT06472375 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Terminated | Arrhythmia Identification in Syncope Patients: ePatch® Versus 24h Holter NCT06310707 | Philips Clinical & Medical Affairs Global | N/A |
| Recruiting | SW-RCT Implementation of Canadian Syncope Risk Score Based Practice Recommendations NCT04972071 | Ottawa Hospital Research Institute | N/A |
| Unknown | Mobile Cardiac Outpatient Telemetry for Unexplained Syncope NCT05957315 | Carilion Clinic | N/A |
| Unknown | Checklists Resuscitation Emergency Department NCT05649891 | Region Skane | N/A |
| Recruiting | The Effect of Water Carbonation on Orthostatic Tolerance NCT05621460 | Simon Fraser University | N/A |
| Completed | Ambulatory Leadless Electrocardiogram Recorder Trial Feasibility NCT05821465 | HelpWear Inc. | — |
| Recruiting | A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of NCT05755737 | University of Calgary | Phase 2 |
| Completed | Autonomic Monitoring in Neurocardiogenic Syncope NCT05907018 | Children's Hospital Medical Center, Cincinnati | — |
| Recruiting | Syncope Trial to Understand Tilt Testing or ECG Recording Tenth Prevention of Syncope Trial NCT05776810 | University of Calgary | N/A |
| Completed | LBBAP Data Collection Registry NCT05887323 | Abbott Medical Devices | — |
| Completed | The U.K. Embryologist Fatigue Study NCT05708963 | TMRW Life Sciences | — |
| Completed | Effect of Pharmacological Interventions on Systolic Blood Pressure Drops (SynABPM 2 Proof-of-concept) NCT05729724 | Istituto Auxologico Italiano | — |
| Unknown | Management of Transitory Loss of Consciousness and Syncopes in the Emergency Department NCT05575934 | University Hospital, Clermont-Ferrand | — |
| Completed | Head-up Tilt Test in Patients With Reflex Syncope and Asystolic Response Who Received a Dual-chamber Pacemaker NCT06038708 | Biotronik SE & Co. KG | — |
| Completed | The Management of Transient Loss of Consciousness and Suspected Syncope in European Emergency Departments NCT05571254 | NHS Lothian | — |
| Recruiting | REmote Cardiac MOnitoring of At-risk SYNCope Patients After Emergency Department Discharge -RCT NCT05066347 | Ottawa Hospital Research Institute | N/A |
| Completed | The U.S. Embryologist Fatigue Study NCT05326802 | TMRW Life Sciences | — |
| Unknown | Improving Management of Emergency Department Patients With Undifferentiated Syncope: Prospective Validation of NCT05538143 | Kaiser Permanente | — |
| Completed | Validation of PMcardio AI-assisted Clinical Assistant in Primary Care NCT05329246 | Powerful Medical | N/A |
| Completed | Rapid Measurement of Adenosine in Syncope Patients NCT05782712 | Istituto Auxologico Italiano | — |
| Active Not Recruiting | CSRS Implementation - A Pilot Study NCT04790058 | Ottawa Hospital Research Institute | — |
| Unknown | Observational and Diagnostical Study on Transient Allostatic Responses of Thyroid Function After Syncopation a NCT04879147 | Ruhr University of Bochum | — |
| Unknown | Clinical Audit on Evaluation of Patient With Syncope at Asssiut University Children Hospital NCT04575376 | Assiut University | — |
| Recruiting | Efficacy of a Right-sided Ablation of the Anterior Ganglionated Plexus for Neurally Mediated Syncope NCT04755101 | Imelda Hospital, Bonheiden | N/A |
| Completed | LUX-Dx Insertable Cardiac Monitor Remote Programming and Performance Study NCT04732728 | Boston Scientific Corporation | — |
| Unknown | Comparative Study of the Sternal Patch System With a Conventional Holter Recorder NCT04241692 | Children's National Research Institute | N/A |
| Completed | BIO|STREAM.ICM Obesity NCT04198220 | Biotronik SE & Co. KG | — |
| Completed | Practical Approaches to Care in Emergency Syncope NCT04533425 | Columbia University | — |
| Recruiting | Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine NCT04615065 | University Medical Center Groningen | — |
| Unknown | Syncope and Implanted Loop Recorder: the Utility of Remote Monitoring and Patients Centered Setting Alarms NCT04435262 | University of Campania Luigi Vanvitelli | — |
| Completed | BIO|STREAM.ICM France NCT04206774 | Biotronik SE & Co. KG | — |
| Recruiting | Global Approach to Faint and Falls NCT05752682 | Istituto Auxologico Italiano | — |
| Unknown | Validation of a Novel Simplified Head up Tilt Test (HUTT) Protocol Versus the Conventional Protocol NCT05029323 | University of Campania Luigi Vanvitelli | N/A |
| Completed | Advancing Understanding of Transportation Options NCT04141891 | University of Colorado, Denver | N/A |
| Completed | Evaluation of Ambulatory Monitoring of Patients After High-risk Acute Coronary Syndrome Using Two Different Sy NCT03940066 | Fundación EPIC | N/A |
| Recruiting | Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs) NCT04075084 | Biotronik SE & Co. KG | — |
| Completed | Master Study of the BIOMONITOR III and Incision and Insertion Tool (FIT OneStep) NCT04025710 | Biotronik SE & Co. KG | N/A |
| Completed | Abbott Brady 3T MRI PMCF NCT03786640 | Abbott Medical Devices | — |
| Unknown | Lower Body Muscle Pre-activation in Initial Orthostatic Hypotension NCT03970551 | University of Calgary | N/A |
| Completed | Improving Safety of Diagnosis and Therapy in the Inpatient Setting NCT04393909 | Brigham and Women's Hospital | N/A |
| Completed | Syncope Trial to Understand Tilt Testing Early or Recorders Study NCT03974412 | University of Alberta | N/A |
| Completed | BIO|CONCEPT.BIOMONITOR III NCT03850327 | Biotronik SE & Co. KG | N/A |
| Completed | Physiologic Pacing Registry NCT03719040 | Abbott Medical Devices | — |
| Completed | ConfirmRxTM: Posture and Activity NCT03803969 | Abbott Medical Devices | N/A |
| Unknown | Hypersensitive Troponin Performance to Identify Syncope at Risk of Serious Adverse Events in the Short Term NCT03528161 | University Hospital, Toulouse | — |
| Completed | Prevalence of PE in ED Patients With Isolated Syncope NCT03487237 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Confirm Rx™ Versus Reveal LINQ™ - Which is More Reliable in Data Transmission? A Randomized Clinical Study NCT03720639 | Sparrow Clinical Research Institute | N/A |
| Completed | Pacemaker Effect With Closed Loop Sensor in Neuromodulated Syncope Refractory to Medical Therapy NCT03876652 | CES University | N/A |
| Completed | Effect of Psychotherapy on Quality of Life and Recurrence of Events in Patients With Recurrent Vasovagal Synco NCT04252729 | Mauricio Ibrahim Scanavacca | N/A |
| Unknown | A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa NCT03231449 | Cardiologie et Développement | — |
| Unknown | Assessing the Risk of Pulmonary Embolism in Patients After Hospitalization for First Episode of Syncope NCT03034525 | Rambam Health Care Campus | — |
| Unknown | Serum Lactate in Convulsive Syncopes Compared to Non-convulsive Syncopes NCT03062683 | RWTH Aachen University | — |
| Completed | Syncope Decision Aid for Emergency Care NCT02971163 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Second Study on Cardio-neuromodulation in Humans NCT02954666 | Imelda Hospital, Bonheiden | N/A |
| Completed | Remote Cardiac Monitoring of Higher-Risk Emergency Department Syncope Patients After Discharge - A Pilot Study NCT02786940 | Ottawa Hospital Research Institute | N/A |
| Completed | Comparison of Continuous Sternal ECG Patch Monitors (Carnation and Zio) Trial NCT02952781 | EvergreenHealth | — |
| Unknown | Comparison of Continuous Sternal ECG Patch Monitors (Carnation and Zio) Trial NCT02031484 | Bardy Diagnostics, Inc. | — |
| Completed | Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Depart NCT02861508 | Yale University | N/A |
| Completed | Theophylline for Low Adenosine Syncope NCT03803215 | Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella | — |
| Recruiting | Genetic Markers of Cardiovascular Disease in Epilepsy NCT02824822 | Mayo Clinic | — |
| Completed | Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. NCT02809131 | Vanderbilt University Medical Center | Phase 3 |
| Completed | Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emerg NCT02781207 | University of Turin, Italy | — |
| Completed | Diagnosis of Arrhythmias in Syncope by Pocket-ECG III® or Conventional Holter NCT02614235 | Complexo Hospitalario Universitario de A Coruña | N/A |
| Completed | Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PA NCT02683174 | NHS Lothian | N/A |
| Completed | Lactate Compared to Creatine Kinase as Diagnostic Marker in Generalized Epileptic Seizure NCT02926703 | RWTH Aachen University | — |
| Completed | Benefit of Dual-chamber Pacing With Closed Loop Stimulation (CLS) in Tilt-induced Cardioinhibitory Reflex Sync NCT02324920 | Biotronik SE & Co. KG | N/A |
| Completed | BIO.MASTER.BioMonitor 2 Study NCT02565238 | Biotronik SE & Co. KG | — |
| Completed | Study of Pulse Pressure During Tilttable and Erigo® in Adult Patients With Acquired Brain Injury NCT02700399 | University of Aarhus | N/A |
| Recruiting | High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2) NCT02448485 | Medical University Innsbruck | — |
| Unknown | Registry Of Acute meDical Emergencies in Brazil NCT02753023 | University of Sao Paulo General Hospital | — |
| Withdrawn | Insulin Therapy and Falls Due to Orthostatic Hypotension NCT01914146 | University of British Columbia | N/A |
| Completed | Oral Water Hydration to Prevent Post-Vaccination Presyncope NCT02353390 | Duke University | N/A |
| Completed | Qualitative Sweat Distribution During Tilt Table Procedure NCT02329548 | Nationwide Children's Hospital | N/A |
| Completed | Urgent Medical and Surgical Conditions During Flights NCT02457455 | Antalya Training and Research Hospital | — |
| Completed | The Diagnostic Performance of Tilt Test in Athletes NCT02316860 | Aristotle University Of Thessaloniki | N/A |
| Completed | Ambulatory Post-Syncope Arrhythmia Protection Feasibility Study NCT02188147 | Zoll Medical Corporation | N/A |
| Unknown | Sternal ECG Patch Comparison Trial NCT02126631 | Bardy Diagnostics, Inc. | — |
| Completed | EEG Characteristics in Youth POTS and/or Syncope NCT02167412 | Nationwide Children's Hospital | — |
| Withdrawn | Autonomous Syncope Onset Prediction and Prevention NCT02684539 | Swiss Federal Institute of Technology | N/A |
| Completed | Acarbose and Older Adults With Postprandial Hypotension NCT01914133 | Kenneth Madden | Phase 2 |
| Completed | Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System NCT01965899 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Unknown | Feasibility of Contact Force Catheter Mapping and Ablation in Epicardial and Endocardial Ventricular Tachycard NCT01847378 | Federal University of São Paulo | — |
| Completed | Improving Syncope Risk Stratification in Older Adults NCT01802398 | University of Pennsylvania | — |
| Completed | Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients NCT01795469 | Nationwide Children's Hospital | N/A |
| Completed | Vagal Nerve Stimulation Assessed by the Diving Reflex: An Investigation Into Mechanisms of Asthma Death NCT02083029 | Hull University Teaching Hospitals NHS Trust | N/A |
| Completed | Haemodynamic Feasibility Study of Sensors Within a Tilting Table Examination NCT01831297 | RWTH Aachen University | — |
| Terminated | Point-of-Care Ultrasound in the Emergency Department Evaluation of Syncope NCT01671371 | Yale University | N/A |
| Completed | Adenosine Testing to DEtermine the Need for Pacing Therapy NCT01481168 | Newcastle-upon-Tyne Hospitals NHS Trust | N/A |
| Completed | Prevalence of Pulmonary Embolism in Patients With Syncope NCT01797289 | University of Padova | N/A |
| Withdrawn | NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness NCT01498471 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Guideline-based Pacing Therapy for Reflex Syncope NCT01509534 | Gruppo Italiano Multidisciplinare per lo Studio della Sincope | — |
| Completed | Syncope: Pacing or Recording in the Later Years NCT01423994 | Canadian Institutes of Health Research (CIHR) | Phase 4 |
| Completed | The Simple ECG Monitoring Trial (Comparison of a Novel Recording System With a Standard Holter Monitor) NCT01382953 | Seattle Institute for Cardiac Research | — |
| Recruiting | Registry of Device Implantation NCT03360227 | Klinik für Kardiologie, Pneumologie und Angiologie | — |
| Completed | Implantable Loop Recorder in Traumatic Syncope NCT04832542 | Azienda Ospedaliera Cardinale G. Panico | — |
| Completed | Monitoring of Syncopes and/or Sustained Palpitations of Suspected Arrhythmic Origin With External Loop-Recorde NCT02253134 | LivaNova | — |
| Withdrawn | fMRI in Blood Phobia Syncope NCT00715065 | Vanderbilt University | — |
| Active Not Recruiting | BAsel Syncope EvaLuation (BASEL IX) Study NCT01548352 | University Hospital, Basel, Switzerland | — |
| Completed | Evaluating an Emergency Department Observation Syncope Protocol for Older Adults NCT01003262 | University of California, Los Angeles | N/A |
| Unknown | Risk of Syncopal Relapses in Patients Treated With Permanent Pacing for Bradyarrhythmic Syncope NCT04229589 | Azienda Ospedaliera Cardinale G. Panico | — |
| Completed | Study of New Implantable Loop Recorder NCT00746564 | Abbott Medical Devices | N/A |
| Unknown | Observational Study of the Sleuth Implantable ECG Monitoring System NCT00717106 | Transoma Medical | — |
| Completed | Heat Stress and Volume Administration NCT00714766 | Rigshospitalet, Denmark | N/A |
| Completed | Evaluation of Syncope,Its Diagnosis, Treatment, Outcome and Prognosis NCT00764985 | St. Luke's-Roosevelt Hospital Center | — |
| Completed | Multi-Site Near Infrared Spectroscopy (NIRS) Monitoring of Children During Tilt Table Testing NCT00659464 | Medical College of Wisconsin | — |
| Unknown | Eastbourne Syncope Assessment Study II NCT00517023 | Eastbourne General Hospital | N/A |
| Unknown | Feasibility Study: Sleuth Monitoring System NCT00719277 | Transoma Medical | N/A |
| Completed | ISSUE3: International Study on Syncope of Uncertain Etiology 3 NCT00359203 | Medtronic Cardiac Rhythm and Heart Failure | Phase 4 |
| Suspended | Exercise and Prevention of Syncope: EXPOSE NCT00203593 | University of Calgary | Phase 1 |
| Unknown | Evaluation of a Mobile Cardiac Outpatient Telemetry System Versus Standard Loop Event Monitor NCT00295204 | Cardionet | — |
| Completed | Prevention of Syncope by Cardiac Pacing in Patients With Bifascicular Block NCT01463358 | Boston Scientific Corporation | N/A |
| Completed | Validation of the San Francisco Syncope Rule NCT00300625 | Albert Einstein College of Medicine | — |
| Completed | Non-Pharmacologic Therapy for Neurocardiogenic Syncope NCT00096902 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 |
| Completed | Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance NCT00093860 | National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2 |
| Withdrawn | One Hospital ClinicalService Project NCT01007474 | Medtronic Italia | — |
| Completed | PREPARE - Primary Prevention Parameters Evaluation NCT00279279 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Completed | Evaluation of Chronic Orthostatic Intolerance NCT00069693 | National Institute of Neurological Disorders and Stroke (NINDS) | — |
| Terminated | International Study on Syncope of Uncertain Etiology NCT00120094 | Azienda USL Reggio Emilia - IRCCS | — |
| Completed | ELIAS: Early Loop-Recorder in Suspected Arrhythmogenic Syncope NCT00170261 | Medtronic Cardiac Rhythm and Heart Failure | Phase 4 |
| Completed | Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope NCT00004479 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | Essential Hypotension and Allostasis Registry NCT02018497 | CES University | — |
| Completed | Identifying High Risk Patients With Syncope NCT00005202 | National Heart, Lung, and Blood Institute (NHLBI) | — |