NCT01914146

Insulin Therapy and Falls Due to Orthostatic Hypotension

Insulin Therapy and Falls Due to Orthostatic Hypotension (Pilot Study)

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

In the proposed study, the investigators examine in older adults with Type 2 diabetes the impact of beginning insulin therapy on the orthostatic drop in blood pressure as well as the response of arterial blood pressure and Doppler measures of cerebral blood flow during upright tilt. The investigators hypothesize that in older adults with Type 2 diabetes, the cardiovascular effects of insulin would precipitate or worsen orthostatic intolerance not present at baseline.

Detailed description

Before and 2 weeks after the start of standard insulin therapy several tests will be done: * orthostatic hypotension will be tested for with 3 orthostatic maneuvers * vasovagal syncope will be tested with 2 tilt table tests, one augmented with 400ug of nitroglycerin * MCA velocity will be measured with a transcranial doppler * Heart Rate and Blood Pressure will be measured throughout the test with a Finometer and Power Lab on a beat to beat basis

Conditions

• Orthostatic Hypotension
• Diabetes
• Syncope

Interventions

Type	Name	Description
OTHER	Insulin	Initiation of insulin administration will be determined as part of standard of care by the subjects diabetologist in the VGH Diabetes Centre and not as part of participation in this study.
OTHER	No Insulin	Study session will occur prior to initiation of insulin therapy.

Timeline

• Start date: 2015-04-01
• Primary completion: 2018-01-02
• Completion: 2018-01-02
• First posted: 2013-08-01
• Last updated: 2018-01-10

Locations

1 site across 1 country: Canada