NCT03803215

Theophylline for Low Adenosine Syncope

Theophylline in Patients With Unexplained Syncope and Low Adenosine. Study Verified by ICM, Controlled by Propensity-score Matching

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 77 (actual)
• Sponsor: Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aims at assessing that theophylline is effective in patients with no prodromes, normal heart and with low values of plasmatic adenosine compared with a propensity-score matched untreated control population who have received an implantable cardiac monitor (ICM) for diagnosis of unexplained or atypical reflex syncope.

Detailed description

Theophylline has been used for 3 decades in ordinary medical practice to tentatively prevent syncopal recurrences in patients affected by neurally-mediated syncope. Observational studies report a recurrence rate with this drug ranging between 12% and 22%. Theophylline was much more effective in selected patients with syncope without prodromes and normal heart who had ECG documentation of long pauses at the time of syncopal attack and low values of baseline plasmatic adenosine. Since theophylline is a non-selective antagonist of purinergic receptors, it has been hypothesized that purinergic receptors are involved in the mechanism of syncope in such patients. Conversely, theophylline was suspected to be ineffective (or less effective) in patients affected by other forms of neurally-mediated syncope. The present study aims at assessing that theophylline is effective in patients with no prodromes, normal heart and with low values of plasmatic adenosine compared with a propensity-score matched untreated control population. This will be a multicenter, non interventional study, verified by ICM, with 2 predefined subgroups: Subgroup #1 * Low adenosine group: Patients with Low Adenosine values (\<0.40 μmol/L) * Normal/high adenosine (≥0.40 μmol/L) group: any other patient Subgroup #2 * Patients with no prodromes or very short prodromes (≤5 sec), normal heart and normal ECG (No prodrome group) * Any other form of atypical neurally-mediated syncope with prodromes \>5 sec. Remote or in-hospital periodic follow-up will be done according to centre's clinical practice for ICM monitoring. Patients will be followed up until the first primary endpoint event with a maximum follow-up of 24 months since start of theophylline treatment.

Conditions

• Syncope

Interventions

Type	Name	Description
DRUG	Theophylline	Oral theophylline initially 600 mg bid and then titrated at the maximum tolerated dose

Timeline

• Start date: 2016-05-11
• Primary completion: 2020-11-30
• Completion: 2020-12-30
• First posted: 2019-01-14
• Last updated: 2021-01-20

Locations

1 site across 1 country: Italy