NCT00203593

Exercise and Prevention of Syncope: EXPOSE

EXercise for the Prevention of Syncope Evaluation

• Status: Suspended
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (planned)
• Sponsor: University of Calgary · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether eight weeks of exercise performed at an intensity of approximately 65% VO2max will improve symptoms associated with fainting (vasovagal syncope).

Detailed description

Background: Vasovagal syncope affects 20-30% of the population, and for those who faint recurrently it causes a significant reduction in the quality of life. Although significant progress has been made in the past 15 years in our understanding of its diagnosis and prognosis, our therapeutic attempts often end in failure. Many patients who have been diagnosed with vasovagal syncope have a reduced orthostatic tolerance. Improved orthostatic tolerance has been achieved through exercise in a number of studies on healthy individuals. However, its efficacy as a means of treatment for those with vasovagal syncope has not been thoroughly explored. Comparison: Subjects will be randomized to one of two groups: an exercise group or control. The exercise group will be asked to train at a target of approximately 65% of their maximum exercise capacity (VO2max) for 8 weeks/3 times per week. The control group will be asked to perform a series of neck rotation exercises. Orthostatic tolerance will be examined in both groups pre and post intervention.

Conditions

• Syncope

Interventions

Type	Name	Description
BEHAVIORAL	Exercise
DEVICE	Blood volume
PROCEDURE	VO2max test
PROCEDURE	Lower body negative pressure
BEHAVIORAL	Heart Rate
PROCEDURE	Blood Pressure
BEHAVIORAL	Total Peripheral Resistance

Timeline

• Start date: 2006-03-01
• Completion: 2007-06-01
• First posted: 2005-09-20
• Last updated: 2007-03-14

Locations

1 site across 1 country: Canada