NCT06870890

Impact of Sarcopenia on Dyspnea in Patients With Asthma

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University Hospital, Clermont-Ferrand · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea . The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction. The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.

Conditions

• Sarcopenia
• Asthma
• Dyspnea
• Dyspnea; Asthmatic
• Cytokines
• Adipokines
• Myokine
• Muscle Disorder

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	muscle evaluation	The investigators will evaluate the muscle mass and muscle strenght for all patients included
BIOLOGICAL	Dosage	Evaluation of the cinetic of biomarkers during exercise
DIAGNOSTIC_TEST	Cardiopulmonary exercise test	CPET
COMBINATION_PRODUCT	Questionnaire and Physical Exam	Evaluating dyspnea, anxiety, sleep, physical activity, quality of life

Timeline

• Start date: 2025-03-25
• Primary completion: 2025-10-01
• Completion: 2026-10-01
• First posted: 2025-03-11
• Last updated: 2025-03-11

Locations

1 site across 1 country: France