Down Syndrome

306 registered clinical trials studyying Down Syndrome — 64 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Escalating Doses of Memantine in Down Syndrome (MEDS-123) NCT07531940	University Hospitals Cleveland Medical Center	Phase 1
Recruiting	Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thy NCT07416201	National Institute of Allergy and Infectious Diseases (NIAID)	—
Recruiting	Endotype DIrected Treatment for OSA in Down Syndrome NCT07280468	University of Arizona	Phase 4
Recruiting	Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Synd NCT07484464	Riphah International University	N/A
Recruiting	HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Sy NCT07296861	UNC Lineberger Comprehensive Cancer Center	N/A
Not Yet Recruiting	Rebound Therapy on Ventilatory Functions in Down Syndrome NCT07425353	Beni-Suef University	N/A
Recruiting	LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome NCT07234695	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	Phase 3
Not Yet Recruiting	Drumming Lessons' Influence on Children With Down Syndrome NCT07156318	Vanderbilt University	N/A
Not Yet Recruiting	Resilience Training Intervention: Its Effect on Parental Acceptance/Rejection and Burden of Children With Down NCT07306923	Ain Shams University	N/A
Not Yet Recruiting	Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome NCT07238465	University of Colorado, Denver	Phase 3
Recruiting	Effects of Jump Rope on Navicular Drop in Down Syndrome NCT07428863	Riphah International University	N/A
Active Not Recruiting	Cervical Spine Abnormalities in Down Syndrome NCT07260136	Sohag University	—
Recruiting	Effects of Vojta Therapy on Functional Mobility and Gait Parameters in Children With Down Syndrome NCT07248267	Riphah International University	N/A
Recruiting	Effects of Powerball in Children With Down Syndrome NCT07244133	Riphah International University	N/A
Recruiting	Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises NCT07248449	Riphah International University	N/A
Not Yet Recruiting	tDCS for Catatonic Depression in Down Syndrome: A Pilot Study NCT06866925	Hôpital le Vinatier	N/A
Recruiting	Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Ana NCT07366593	Badr University	—
Not Yet Recruiting	Nutritional Status in Children With Down Syndrome NCT06989060	Assiut University	—
Completed	Dual Task Balance Exercises and Vestibular Stimulation for Children With Down Syndrome NCT06998199	Riphah International University	N/A
Active Not Recruiting	Effects of (tDCS) Combined With Virtual Reality Versus CPT on Brain, Cognitive, and GMS in Children With DS. NCT07385066	Superior University	N/A
Recruiting	The Effects Of "Minds In Motion The Maze" on Balance and Gate In Children With Down Syndrome NCT06955052	Riphah International University	N/A
Completed	Comparative Effects of Dual Task Training and Embodied Learning on Dual Task Performance in Children With Down NCT06943144	Riphah International University	N/A
Not Yet Recruiting	Effects of Interactive Sensory Play on Manual Dexterity in Down Syndrome NCT06943352	Riphah International University	N/A
Recruiting	Nordic Walk on Balance and Functional Strength in Children With Down Syndrome NCT06943508	Riphah International University	N/A
Recruiting	Effects of Down Dog Yoga on Pre-writing Skills in Children With Down Syndrome NCT06977672	Riphah International University	N/A
Not Yet Recruiting	Effects of Task-oriented Training on Visual-motor Integration and Upper Limb Function in Children With Down Sy NCT06943261	Riphah International University	N/A
Recruiting	Measuring Aided Language Development NCT06512168	University of Central Florida	N/A
Not Yet Recruiting	Psychometric Properties of the Turkish Version of the Modified Mini Mental State Examination NCT06865248	Eastern Mediterranean University	—
Completed	Effects of Play Based Therapy on Attention Level of Children With Down Syndrome NCT06893666	Riphah International University	N/A
Recruiting	Sleep Intervention and Quality of Life in Down Syndrome NCT06783725	University of Alabama at Birmingham	N/A
Recruiting	Aerobic Exercise With and Without Low Calorie Diet on Adiposity and BMI of Down Syndrome NCT06943170	Riphah International University	N/A
Enrolling By Invitation	Shared Book Reading to Promote Mental Well-being Among Young People with and Without Down's Syndrome NCT06813625	University of Macau	N/A
Recruiting	Non-Invasive Brain Stimulation to Improve Language in Down Syndrome. NCT07044804	Floriana Costanzo	N/A
Recruiting	Physical Activity and Community EmPOWERment Project NCT06740162	University of North Carolina, Chapel Hill	N/A
Recruiting	How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome NCT06951516	Michigan State University	N/A
Terminated	Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION NCT06673069	Ionis Pharmaceuticals, Inc.	Phase 1
Not Yet Recruiting	Effects of Aerobic-Based Virtual Reality Exercise Training and Traditional Aerobic Exercise Training on Physic NCT06617637	Bezmialem Vakif University	N/A
Not Yet Recruiting	Up, Down, and All Around: Evaluating Mobility Devices for Young Children with Down Syndrome NCT06591559	University of Washington	N/A
Completed	Effect of Whole Body Vibration on Down Syndrome NCT06838754	Riphah International University	N/A
Recruiting	Effects of High Intensity Interval Training in Down Syndrome NCT06777394	Riphah International University	N/A
Recruiting	Effects of Pelvic Girdle Stabililty With Use of Therapeutic Taping in Down Syndrome NCT06770218	Riphah International University	N/A
Recruiting	Brain Outcomes With Lifestyle Change in Down Syndrome NCT05985486	University of Kansas Medical Center	N/A
Recruiting	Swiss Ball Versus Frenkel Exercises Effects in Down Syndrome NCT06732713	Riphah International University	N/A
Active Not Recruiting	Group-based Resistance Training for Adults With Down Syndrome NCT07347912	Saint John of God Intellectual Disability Services - Dublin South East	N/A
Completed	A Comparison of Cognitive-Motor Dual-Task Exercise and Exergaming on Balance, Functional Mobility, and Executi NCT06146907	safia Darweesh halwsh	N/A
Completed	Effects of Cuevas Medek Exercises on Trunk Control and Balance in Children With Down Syndrome NCT06461858	Riphah International University	N/A
Completed	Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome NCT06537648	University of Kansas Medical Center	N/A
Recruiting	Harness-based Mobility Intervention for Infants With Down Syndrome NCT06219863	Boston University Charles River Campus	N/A
Completed	Visual Perception Intervention Programmes Impact on Down Syndrome Affiliate Children's Fine Motor and Visual P NCT06531213	Riphah International University	N/A
Completed	Hippotherapy Versus Balance Therapy on Funvtional Mobility in Down Syndrome NCT06502652	Riphah International University	N/A
Completed	Effects of Lower Limb Fitness Program in Children With DS NCT06407895	Riphah International University	N/A
Completed	Effects of Bin Therapy on Finger Gnosia And Fine Motor Skill NCT06576206	Riphah International University	N/A
Completed	Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric NCT06336577	Centre Hospitalier Sud Francilien	—
Completed	Phosphoproteomic Profile of Children With Down Syndrome NCT06279208	Perha Pharmaceuticals	—
Completed	Clinical Comparison of a Postbiotic-gel With Placebo Gel for Gingival Inflammation in Patients With Down Syndr NCT06293911	University of Pavia	N/A
Unknown	The Coping With and Caring for Infants With Special Needs Intervention in Down Syndrome Infants NCT06197035	University of Seville	N/A
Active Not Recruiting	Proactive Speech and Language Intervention for Infants With Down Syndrome NCT06450509	Arizona State University	N/A
Completed	Caregiver-Involved Nutrition Education in Down Syndrome NCT07330128	Hülya YILMAZ ÖNAL	N/A
Recruiting	Patterns of Neurodevelopmental Disorders NCT06213090	Richard Frye	—
Recruiting	Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Di NCT06206824	Perha Pharmaceuticals	Phase 1
Recruiting	Down Syndrome, Physical Activity and Sleep Apnea NCT06061562	University Hospital, Grenoble	—
Completed	Effects of Maze Activities in Down's Syndrome NCT06234644	Riphah International University	N/A
Unknown	Gynaecological Follow-up of Women With Down Syndrom Aged 18 to 30 in France NCT06117228	Université de Reims Champagne-Ardenne	—
Completed	Effects of Rhythmic Aerobic Exercises on Functional Balance in Children With Down Syndrome NCT06196983	Riphah International University	N/A
Completed	Action Observation Therapy on Balance in Children With Down Syndrome NCT06198075	Riphah International University	N/A
Recruiting	A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia NCT05702645	Children's Oncology Group	—
Recruiting	The (Cost)Effectiveness of a Social Robot for Persons with Problems in Daily Structure and Planning in Disabil NCT06592404	Academy Het Dorp	N/A
Completed	Effects of Dohsa Hou Exercises on Functional Mobility NCT06131099	Riphah International University	N/A
Recruiting	Down Syndrome Obstructive Sleep Apnea NCT06043440	Brigham and Women's Hospital	Phase 2
Withdrawn	Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome NCT05482334	University of Colorado, Denver	Phase 2
Unknown	Effect of Whole Body Vibration Versus Core Stability Exercises on Balance and Muscle Strength in Children With NCT06036069	Ragaee Saeed Mahmoud	N/A
Completed	Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome NCT05995223	University of Nevada, Las Vegas	N/A
Completed	Effects of Orofacial Therapy and Therapeutic Yoga in Children With Down Syndrome NCT06352151	Hasan Kalyoncu University	N/A
Active Not Recruiting	Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome NCT05933603	University of Arizona	Phase 2
Recruiting	Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) NCT05508971	Oregon Health and Science University	N/A
Completed	Effect of Aerobic Training on Sleep Problems and Pulmonary Functions in Children With Down Syndrome NCT05861141	Cairo University	N/A
Completed	Effect Of Pilates On Postural Control And Balance In Children With Down's Syndrome NCT05969873	Riphah International University	N/A
Active Not Recruiting	Therapies for Down Syndrome Regression Disorder NCT05662228	University of Colorado, Denver	Phase 2
Terminated	LIFE-DSR-Biomarker Sub-study of Biomarkers in Down Syndrome Related Alzheimer's Disease (DS-AD) NCT06860373	LuMind IDSC Foundation	Phase 3
Unknown	Pilates Exercises and Down Syndrome NCT05928949	Cairo University	N/A
Completed	Effects of Active Video Gaming on Pre-handwriting Skills of Children With Down Syndrome. NCT05978778	Riphah International University	N/A
Completed	Effects of Plyometric Exercises on Static and Dynamic Balance of Children With Down,s Syndrome. NCT05951543	Riphah International University	N/A
Completed	Relationship Between BMI, Physical Fitness and Motor Skills in Children With Down's Syndrome NCT05904821	Riphah International University	—
Completed	Effect of Aerobic Exercises on Static & Dynamic Balance NCT05915780	Riphah International University	N/A
Completed	Effect Of Brain Gym Exercises On Postural Stability In Children With Down Syndrome NCT05769556	Aliaa Altohamy Goda	N/A
Unknown	Virtual Reality Technology For Cognitive Functions Of Children With Down Syndrome NCT05849818	Cairo University	N/A
Completed	Video Based Breathing Exercise Rehabilitation NCT06125990	Saglik Bilimleri Universitesi	N/A
Unknown	Weight Bearing Exercises With and Without Jaffrey's Core Stability Exercise Training in Children With Down Syn NCT05719662	Riphah International University	N/A
Enrolling By Invitation	Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities NCT05301361	University of California, Davis	Phase 1
Completed	Motor Intervention Whit the Intorus Tool on Children With Down Syndrome NCT05740046	University of Extremadura	N/A
Completed	Effects of Simulated Equestrian Therapy on Motor Proficiency and Gait Parameters Among Down Syndrome Children NCT05912803	Ziauddin University	N/A
Completed	Investigating the Impact of JASPER Behavioral Therapy in Children With Down Syndrome NCT05638412	Boston Children's Hospital	N/A
Completed	GameSquad for Adults With Down Syndrome NCT05473247	University of Kansas Medical Center	N/A
Recruiting	Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome NCT06465823	Stefano Vicari	Phase 2
Completed	Occupational Therapy Home Programs in Children With Down Syndrome NCT06244108	Bezmialem Vakif University	N/A
Recruiting	Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome NCT05767216	Institut Jerome Lejeune	N/A
Completed	Phase 1/2 Trial of AEF0217 in Participants With Down Syndrome NCT05748405	Aelis Farma	Phase 1 / Phase 2
Completed	Fluoxetine Treatment of Depression in Down Syndrome NCT05458479	Massachusetts General Hospital	Phase 4
Recruiting	Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome NCT06030349	Children's Health Ireland	—
Recruiting	Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia NCT05527652	University of Michigan	N/A
Recruiting	Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin NCT05767203	Institut Jerome Lejeune	N/A
Completed	Blood Flow and Blood Pressure Investigation in Down Syndrome NCT05528549	University of Illinois at Chicago	Phase 3
Completed	TheraTogs Versus Reciprocal Electrical Stimulation on Children With Diplegic Cerebral Palsy: a Randomized Cont NCT05702632	Cairo University	N/A
Unknown	Effects of Core Stability Exercises With and Without Treadmill Training on Balance in Children With Down Syndr NCT05460910	Riphah International University	N/A
Completed	Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome NCT05059041	Ohio State University	Phase 2
Completed	Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS) NCT05312177	Carelon Research	—
Unknown	Whole-Body Vibration Versus Gravity Force Stimulation on Postural Stability in Children With Down Syndrome NCT05330741	Beni-Suef University	N/A
Completed	Neuro-Nutrition to Support Physiological Function and Cognitive Skills in People With Down Syndrome, Autism Sp NCT07165509	Elizabeth Guadalupe Ibarra Coronado	N/A
Completed	Qualitative Exploratory Study Among Reunionese Women and Their Partners Who Have a Child With Trisomy 21 NCT04811534	Centre Hospitalier Universitaire de la Réunion	—
Completed	Use of Partial Body Weight Support Play Environment to Encourage Mobility and Exploration in Infants With Down NCT05307523	University of Washington	N/A
Completed	Down Syndrome Autonomic Nervous System Induction Bradycardia NCT05120531	Children's Hospital Medical Center, Cincinnati	—
Completed	Role of Early Motor Experience in Infants With Down Syndrome NCT05144373	Georgia State University	N/A
Recruiting	Gamma Frequency Stimulation in Individuals With Down Syndrome NCT05196984	Massachusetts Institute of Technology	N/A
Active Not Recruiting	Transcranial Photobiomodulation With Near-Infrared Light for Language in Individuals With Down Syndrome NCT04668001	Massachusetts General Hospital	N/A
Completed	The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic NCT05098600	Faculty Hospital Kralovske Vinohrady	—
Completed	Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR) NCT05020366	University of Pittsburgh	N/A
Withdrawn	A Study of ACI-24 in Adults With Down Syndrome NCT04373616	AC Immune SA	Phase 2
Completed	Blood Flow Regulation in Individuals With Down Syndrome - Training Study NCT04854122	University of Nevada, Las Vegas	N/A
Active Not Recruiting	Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition NCT05231798	Vanderbilt University Medical Center	Phase 2
Unknown	Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women? NCT05492981	National University Hospital, Singapore	N/A
Active Not Recruiting	Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apne NCT04801771	Inspire Medical Systems, Inc.	Phase 3
Completed	Elucidating Age-related Comorbidity Patterns in Down Syndrome (DS) NCT05310552	King's College London	—
Recruiting	Trial-Ready Cohort-Down Syndrome (TRC-DS) NCT04165109	University of Southern California	—
Completed	Turkish Adaptation of Segmental Assessment of Trunk Control Scale NCT04657276	Hacettepe University	—
Completed	Effect of the Sensory Integration Approach on Balance and Motor Coordination in Children With Down Syndrome NCT05583565	Cairo University	N/A
Completed	Impact of an Orthotic Garment on Gross Motor Skills for Infants With Down Syndrome NCT04603352	University of St. Augustine for Health Sciences	N/A
Completed	OHRQoL and Parental Perception in a Group of Children and Adolescents With Down Syndrome: A Cross NCT04394221	Cairo University	—
Completed	Assessing Malleability of Spatial Abilities in Down Syndrome NCT05332912	University of Alabama, Tuscaloosa	N/A
Recruiting	PAP for Children With DS and OSAS NCT04132999	University of Miami	N/A
Unknown	Assessment of Skills and Behaviors in Children With Down Syndrome NCT04754178	Universidad de Granada	—
Unknown	Prospective Monitoring of Antibody Response Following COVID-19 Vaccination in Patients With Down Syndrome. NCT05145348	UMC Utrecht	—
Completed	Vascular Health and Risk Factors in Children With Down Syndrome NCT04735874	University of Utah	—
Unknown	Activities and Participation of Children With Down Syndrome NCT05152251	Hacettepe University	—
Completed	The Effects of Virtual Zumba® in Individuals With Developmental Disabilities NCT05198232	Auburn University	N/A
Completed	Effect of Exercise Intensity on Vitamin D NCT05024110	Taif University	N/A
Unknown	Assessment of Neural Oscillations in Adult Subjects With Down Syndrome and Typically Developing Subjects in Re NCT04791124	Parc de Salut Mar	—
Completed	Early Detection of Children With Developmental Disabilities in Assiut Governorate NCT06263777	Beni-Suef University	N/A
Recruiting	A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse NCT04546399	National Cancer Institute (NCI)	Phase 2
Completed	Effect of Hippotherapy in Children With Down Syndrome NCT05297149	Halic University	N/A
Completed	Remote Exercise Study for Individuals With Down Syndrome NCT04647851	University of Nevada, Las Vegas	N/A
Completed	Medications for Obstructive Sleep Apnea In Children With Down Syndrome NCT04115878	University of Arizona	Phase 2
Completed	Tofacitinib for Immune Skin Conditions in Down Syndrome NCT04246372	University of Colorado, Denver	Phase 2
Recruiting	Evaluating Treatment of ADHD in Children with Down Syndrome NCT04219280	Children's Hospital Medical Center, Cincinnati	Phase 4
Completed	Investigation of Cardiopulmonary Parameters, Motor Development and Muscle Strength in DS With and Without CHD NCT05191654	Atılım University	—
Completed	Life Skills Improved in Children With Down Syndrome After Using Assistive Technology NCT05343468	MapHabit, Inc.	N/A
Completed	Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial NCT04767412	Cairo University	N/A
Recruiting	GnRH Therapy on Cognition in Down Syndrome NCT04390646	Nelly Pitteloud	Phase 2 / Phase 3
Unknown	Pulmonary Health in Children With Down Syndrome NCT04398862	University of Colorado, Denver	—
Completed	Developing a Down Syndrome Health Instrument NCT04631237	Massachusetts General Hospital	—
Recruiting	Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Stan NCT04278404	Duke University	—
Terminated	Training Balance Among People With Neurodevelopmental Disabilities NCT04293120	University of Hartford	N/A
Completed	The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome NCT04048759	University of Kansas Medical Center	N/A
Completed	Efficacy of AAC for Functional Communication NCT04583332	Riphah International University	N/A
Completed	Exercise Intensity for Down Syndrome Children NCT05271201	Taif University	N/A
Completed	Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome NCT03903666	Institut Jerome Lejeune	N/A
Unknown	Protocol for a Non-randomized Survey in Down Syndrome People Who Practice Sports. Self and Observers´ Percepti NCT04037579	Universidad de Córdoba	—
Completed	Bobath and Vojta Therapy for DS NCT04536506	Pamukkale University	N/A
Active Not Recruiting	Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD) NCT04022460	Children's Hospital of Eastern Ontario	—
Completed	Effect of Core Stability Exercises and Balance Training in Postural Control Among Down Syndrome NCT04818437	Riphah International University	N/A
Completed	Self-Monitoring Shopping Intervention NCT04020302	Columbia University	N/A
Terminated	Down Syndrome Speech Intelligibility Diagnostic Treatment Study NCT04059354	University of Wisconsin, Madison	N/A
Completed	Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1) NCT04124471	Children's Hospital of Philadelphia	N/A
Active Not Recruiting	A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lympho NCT03914625	National Cancer Institute (NCI)	Phase 3
Completed	Delivering Early Intervention to Children With Down Syndrome NCT03935620	Oregon Health and Science University	N/A
Completed	Infants With Down Syndrome on a Different Surface NCT04539535	Hacettepe University	N/A
Completed	Healthy Sleep for Children With Down Syndrome NCT03922165	Brigham and Women's Hospital	—
Unknown	Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer's Disease (TriAL21) NCT03901261	Institut Jerome Lejeune	N/A
Completed	Awareness Levels of Caregivers of Disabled Children NCT05228405	Kahramanmaras Sutcu Imam University	—
Unknown	Clinical Validation of the Bordeaux Maze Test NCT04241042	Parc de Salut Mar	—
Completed	Assessment of Hypotonia in Children With Down Syndrome NCT05131542	Universidad de Murcia	—
Completed	Effect of Neuro Developmental Therapy in Infants With Down Syndrome NCT04816409	Riphah International University	N/A
Completed	Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities NCT03684512	University of Kansas	N/A
Completed	Motorized Movement Therapy & Pulmonary Functions in Down Syndrome NCT04787861	Taibah University	N/A
Completed	How Stuttering and Gestures Influence the Intelligibility of Individuals With Down Syndrome NCT03698539	Universitaire Ziekenhuizen KU Leuven	—
Completed	Effects of Stretch-shortening Cycle Exercises Postural Control in Down Syndrome NCT04966403	Qassim University	N/A
Enrolling By Invitation	Parent and Infant Inter(X)Action Intervention (PIXI) NCT03836300	RTI International	N/A
Completed	Balance Bike Training in Down Syndrome NCT03677245	University of Mississippi Medical Center	N/A
Suspended	Evaluation of Patients With Down Syndrome Compliance to Dental Therapy NCT05755464	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	—
Completed	The Impact of an 8-week Supported Exercise Program on Fitness and Symptoms in Adolescents With Down Syndrome NCT03192540	Boston Children's Hospital	N/A
Completed	Investigating Trunk Control in Young Children With Down Syndrome NCT03544840	Texas Woman's University	N/A
Active Not Recruiting	Validation of Sleep Questionnaires in the Down Syndrome Population NCT03771469	Oregon Health and Science University	N/A
Active Not Recruiting	Evaluating Cognitive Outcomes in Down Syndrome NCT04208685	Children's Hospital Medical Center, Cincinnati	—
Terminated	Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome NCT03551418	Wake Forest University Health Sciences	N/A
Terminated	Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome NCT03778528	University of Colorado, Denver	—
Completed	Building Sentences With Preschoolers Who Use AAC NCT03538925	University of Central Florida	Phase 2
Unknown	Turkish Version of The Measure of Processes of Care (MPOC) NCT03508583	Hacettepe University	—
Unknown	QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease NCT03602378	University of Split, School of Medicine	—
Terminated	Storybook Reading in Individuals With Down Syndrome NCT03764761	Penn State University	N/A
Completed	Strategies for Teaching Verbs NCT03441685	Vanderbilt University Medical Center	N/A
Terminated	Blood Flow in Individuals With Down Syndrome NCT03590665	University of Illinois at Chicago	N/A
Completed	The Effects of Kinesiotaping on Balance in Children With Down Syndrome. NCT04156607	Gazi University	N/A
Completed	Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS) NCT03624556	Parc de Salut Mar	N/A
Unknown	Correlation Between Optic Nerve Vessel Anomalies, Serum Angiogenic Factors and Renal Anomalies in Down Syndrom NCT03206957	Queen Fabiola Children's University Hospital	N/A
Completed	19/5000 (SYNAPSOT21) Predictive Factors of Sleep Apnea Syndrome in Down Syndrome NCT03445962	University Hospital, Grenoble	—
Completed	VAlidation of a Lower Cost aneUploidy scrEen NCT03087357	Women and Infants Hospital of Rhode Island	—
Completed	An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You NCT04227197	Massachusetts General Hospital	N/A
Withdrawn	Physiological Abnormalities Associated with Down Syndrome NCT03087500	University of Arkansas	—
Unknown	Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome NCT03210675	Institut Jerome Lejeune	N/A
Recruiting	Retinal Imaging in Neurodegenerative Disease NCT03233646	Duke University	—
Completed	Effects of Karate in Adolescents With Down Syndrome NCT03058640	University of Michigan	N/A
Completed	Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disa NCT04035967	Sanko University	—
Recruiting	ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 NCT03286634	National Hospital Organization Nagoya Medical Center	Phase 2
Completed	Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome NCT03135236	Wake Forest University Health Sciences	N/A
Completed	Application of LLM Care and Related Affective Computing Systems on Persons With Special Needs NCT04390321	Aristotle University Of Thessaloniki	N/A
Completed	The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients NCT02971254	Asklepieion Voulas General Hospital	Phase 2
Completed	Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD) NCT02759887	St. Joseph's Hospital and Medical Center, Phoenix	N/A
Completed	the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome NCT04751136	Mansoura University Children Hospital	Phase 2
Completed	Performance Analysis in Down Syndrome on Mobile Phone NCT02882698	University of Sao Paulo	N/A
Completed	Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome NCT02859389	St. Jude Children's Research Hospital	—
Unknown	Interrater Reliability of Infant Motor Profile NCT03188107	Abant Izzet Baysal University	—
Completed	Effects of Infant Massage on Development of Down Syndrome Babies NCT03084497	University of Seville	N/A
Completed	Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) NCT02895802	Wake Forest University Health Sciences	N/A
Recruiting	The Human Trisome Project NCT02864108	University of Colorado, Denver	—
Completed	Oral Health Promotion Among Preschool Children With Special Needs NCT03522337	The University of Hong Kong	N/A
Completed	Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome NCT02738450	AC Immune SA	Phase 1
Terminated	Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study NCT02612376	University of Colorado, Denver	—
Completed	Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies NCT03200041	Premaitha Health	N/A
Active Not Recruiting	Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in NCT02521493	Children's Oncology Group	Phase 3
Terminated	A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age NCT02484703	Hoffmann-La Roche	Phase 2
Completed	Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome NCT02421276	University of Colorado, Denver	N/A
Completed	Expanded Noninvasive Genomic Medical Assessment: The Enigma Study NCT02787486	Progenity, Inc.	—
Completed	Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome NCT02481765	University of Wisconsin, Madison	N/A
Completed	Treatment of Sleep Disturbances in School-age Children With Down Syndrome NCT02996175	Children's Hospital Medical Center, Cincinnati	N/A
Completed	Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement NCT02451657	Hoffmann-La Roche	—
Completed	Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged NCT02431117	Chugai Pharmaceutical	—
Completed	Investigation of the Safety of Intranasal Glulisine in Down Syndrome NCT02432716	HealthPartners Institute	Phase 1
Unknown	Whole Blood Specimen Collection From Pregnant Subjects NCT02430584	Progenity, Inc.	—
Unknown	Non-Invasive Screening for Fetal Aneuploidy NCT02317965	Progenity, Inc.	—
Completed	Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome NCT02719600	University of Sao Paulo	N/A
Completed	Weight Management for Adolescents With IDD NCT02561754	University of Kansas Medical Center	N/A
Completed	A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive S NCT02344108	Christopher Hartnick, M.D.	N/A
Unknown	Trisomy 21 in Adulthood NCT01663675	University Hospital, Strasbourg, France	—
Completed	Down Syndrome Memantine Follow-up Study NCT02304302	University Hospitals Cleveland Medical Center	Phase 2
Terminated	Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome NCT02288702	Milton S. Hershey Medical Center	—
Terminated	Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies NCT02226315	Sequenom, Inc.	—
Completed	Phenotypic Specific Communication Intervention for Children With Down Syndrome NCT02158390	Vanderbilt University	N/A
Completed	A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) NCT02024789	Hoffmann-La Roche	Phase 2
Completed	Non Invasive Prenatal Testing of Down Syndrome NCT02127515	Assistance Publique - Hôpitaux de Paris	N/A
Completed	Non-Invasive Chromosomal Evaluation of Trisomy Study NCT02201862	Cindy Cisneros	—
Completed	Intensive Dysarthria Sessions in Adults and Children With Down Syndrome NCT01684670	Duke University	N/A
Completed	A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of NCT01920633	Hoffmann-La Roche	—
Completed	A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy an NCT02094053	Eisai Co., Ltd.	Phase 2
Recruiting	DS-Connect®: The Down Syndrome Registry NCT01950624	University of Colorado, Denver	—
Completed	A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia NCT01791725	OPKO Health, Inc.	Phase 2
Completed	Down Syndrome Biomarker Initiative (DSBI) NCT02141971	Michael Rafii	—
Completed	Nicotine Treatment of Cognitive Decline in Down Syndrome NCT01778946	Vanderbilt University Medical Center	Phase 1 / Phase 2
Completed	Down Syndrome Metabolic Health Study NCT01821300	Children's Hospital of Philadelphia	—
Unknown	Digital Dysmorphology Project NCT02651493	Kevin Cleary	N/A
Completed	Treatment Trial of Subclinical Hypothyroidism in Down Syndrome NCT01832753	Children's Hospital of Philadelphia	N/A
Completed	Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People NCT03267602	National Taiwan University Hospital	N/A
Unknown	Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21 NCT01975545	Universidad Autonoma de San Luis Potosí	Phase 2
Completed	Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies NCT01597063	Sequenom, Inc.	—
Completed	Comparison of Aneuploidy Risk Evaluations NCT01663350	Verinata Health, Inc.	—
Completed	Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development o NCT01576705	Institut Jerome Lejeune	Phase 3
Completed	Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies NCT01555346	Sequenom, Inc.	—
Completed	Amniotic Fluid Ischemia Modified Albumin as a Novel e Prenatal Diagnostic Marker for Down Syndrome NCT04293380	Karadeniz Technical University	N/A
Completed	A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cogn NCT01580384	Hoffmann-La Roche	—
Completed	A Study of RG1662 in Individuals With Down Syndrome NCT01436955	Hoffmann-La Roche	Phase 1
Completed	Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite NCT01390558	Oregon Health and Science University	—
Recruiting	Specimen Collection from Pregnant Women At Increased Risk for Fetal Aneuploidy NCT01429389	Sequenom, Inc.	—
Enrolling By Invitation	Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome NCT01902407	Children's Hospital Medical Center, Cincinnati	—
Completed	Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome NCT01808508	Children's Hospital of Philadelphia	N/A
Active Not Recruiting	Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic NCT01190930	Children's Oncology Group	Phase 3
Completed	An Interactive Informed Consent and Education Program for Pregnant Women NCT01176019	Northwestern University	Phase 1
Completed	A Bicycle Training Intervention NCT02046889	University of Michigan	N/A
Completed	Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65 NCT01148121	University of Arkansas	N/A
Completed	Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. NCT01394796	Parc de Salut Mar	Phase 2
Completed	Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome NCT00951730	Centre Hospitalier Universitaire de Saint Etienne	—
Completed	Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome NCT02380638	Universidad de Zaragoza	N/A
Completed	Gait in Children With Down Syndrome While Wearing Orthoses NCT01598350	University of Puget Sound	N/A
Completed	Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies NCT01052688	Sequenom, Inc.	—
Completed	Rivastigmine Study in Adolescents With Down Syndrome NCT01084135	Duke University	Phase 1 / Phase 2
Completed	Frequency of Metabolic Syndrome in Down Syndrome Patients NCT00864461	Universidad de Guanajuato	—
Completed	Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker NCT00971334	Sequenom, Inc.	—
Unknown	Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome NCT00965835	National Institute on Aging (NIA)	—
Completed	Natural History of Amyloid Deposition in Adults With Down Syndrome NCT01303133	University of Pittsburgh	—
Unknown	Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia NCT00966017	National Institute on Aging (NIA)	—
Completed	Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid. NCT00928304	Life Molecular Imaging SA	Phase 2
Unknown	Trends in Intellectual Development in Down Syndrome NCT00954382	National Taiwan University Hospital	—
Completed	Non-Invasive Screening for Fetal Aneuploidy NCT00847990	Sequenom, Inc.	—
Completed	A New Prenatal Blood Test for Down Syndrome NCT00877292	Women and Infants Hospital of Rhode Island	—
Terminated	Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysf NCT00754013	Eisai Inc.	Phase 3
Terminated	Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysf NCT00754052	Eisai Inc.	Phase 3
Completed	Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down NCT01112683	University of Colorado, Denver	Phase 4
Completed	The Experience of Caregivers of Children With Down Syndrome NCT00695695	National Human Genome Research Institute (NHGRI)	—
Terminated	Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive NCT00675025	Eisai Inc.	Phase 2
Terminated	Neuromuscular Characteristics of Individuals With Down Syndrome (DS) NCT00643955	State University of New York - Upstate Medical University	—
Completed	Efficacy of Rivastigmine in Patients With Down Syndrome NCT00748007	National Taiwan University Hospital	N/A
Completed	Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunctio NCT00570128	Eisai Inc.	Phase 2
Unknown	Oral Language in Children With Down Syndrome NCT00952354	University of Sao Paulo	—
Completed	Down Syndrome and Continuous Positive Pressure Therapy NCT00394290	Institut Jerome Lejeune	N/A
Completed	Parent Supported Weight Reduction in Down Syndrome NCT01256112	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	N/A
Completed	Hippotherapy to Improve the Balance of Children With Movement Disorders NCT01313325	Central Michigan University	N/A
Completed	Functional Communicative Profile of Children With Down Syndrome NCT00844259	University of Sao Paulo	—
Completed	Symbolic Representation in Young Children With Down Syndrome NCT00668980	University of Sao Paulo	—
Completed	Treadmill Training and Orthotic Use in Infants With Down Syndrome NCT00825175	University of Michigan	N/A
Completed	Augmentative and Alternative Communication (AAC) and Lexical Gain in Children With Down Syndrome NCT00689988	University of Sao Paulo	N/A
Withdrawn	Liq-NOL Efficacy in Pediatric Patients With Down Syndrome NCT00891917	Children's Hospital Medical Center, Cincinnati	Phase 2
Completed	Correlations Phenotype / Genotype in Down Syndrome NCT01034280	Institut Jerome Lejeune	—
Completed	Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trime NCT00287417	University Hospital, Strasbourg, France	—

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