| Not Yet Recruiting | Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS NCT04366115 | AVM Biotechnology Inc | Phase 1 |
| Not Yet Recruiting | Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults NCT06564207 | Inova Health Care Services | Phase 2 |
| Withdrawn | Use of hUC-MSC Product (BX-U001) for the Treatment of COVID-19 With ARDS NCT04452097 | Baylx Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | A Controlled Study to Evaluate the Efficacy of Allogeneic MesenCure for the Treatment of Patients With ARDS NCT05497401 | BonusBio Group Ltd | Phase 3 |
| Not Yet Recruiting | Machine Learning Prediction of Mortality After Prone Positioning in ARDS NCT07445061 | Shanghai Zhongshan Hospital | — |
| Not Yet Recruiting | HemodynamIc eFfects of Lung Collapse and overdIstension During ARDS NCT07423520 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS NCT07362537 | Southeast University, China | N/A |
| Withdrawn | Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome NCT04725110 | University of Minnesota | Phase 2 |
| Recruiting | High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS NCT07298889 | Chongqing Medical University | N/A |
| Recruiting | Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Childr NCT07193719 | Charite University, Berlin, Germany | Phase 1 / Phase 2 |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab NCT06701656 | PPD Development, LP | Phase 2 |
| Not Yet Recruiting | Electrical Impendance Tomography Usage in ICU NCT07184580 | Erasme University Hospital | — |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab NCT06701682 | PPD Development, LP | Phase 2 |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart NCT06701669 | PPD Development, LP | Phase 2 |
| Recruiting | JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record) NCT06703073 | PPD Development, LP | Phase 2 |
| Recruiting | Prognosis of Veno-Venous Extracorporeal Membrane Oxygenation in Emergency Thoracic Surgery NCT07016685 | Centre Hospitalier Universitaire, Amiens | — |
| Not Yet Recruiting | Effects of Ventilation With Tidal Volume Adjusted on Driving Pressure on Ventilation/Perfusion Ratios and Hemo NCT06817629 | Assistance Publique - Hôpitaux de Paris | — |
| Active Not Recruiting | Echocardiographic Right Ventricular Evaluation in Assessment of ARDS Lung Recruitment (ECHO-REVEAL) NCT06812949 | University of Bari | — |
| Not Yet Recruiting | Impact of Belt Position on the Results of PEEP Titration by EIT During ARDS NCT06541522 | Centre Hospitalier Saint Joseph Saint Luc de Lyon | N/A |
| Recruiting | The Effect of Single Lung Ventilation Duration on Postoperative Pulmonary Complications in Thoracic Surgery NCT07100860 | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | — |
| Active Not Recruiting | Electrical Impedance Tomography-Based Dynamic Ventilation-Perfusion Functional Phenotype Trajectory in Acute R NCT07370610 | Ruijin Hospital | — |
| Active Not Recruiting | Effectiveness of Low Volume and Low Pressure in Severe Hypoxemic Patients NCT06513299 | Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva | — |
| Not Yet Recruiting | Compare Between APRV and Bipap Ventilation in ARDS Patients NCT06755320 | Ain Shams University | N/A |
| Recruiting | Lateral Positioning and Prone Positioning in ARDS Patients NCT06647784 | Centre Hospitalier de Bastia | N/A |
| Recruiting | Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating ECCO2 NCT07161271 | Hong Kong University | — |
| Not Yet Recruiting | Mechanical Ventilation-induced Acute Kidney Injury [AKI] NCT06638255 | Pontificia Universidad Catolica de Chile | N/A |
| Recruiting | Pilot Study on HA380 Column Use in Critically Ill Patients Receiving Extracorporeal Support. NCT06179771 | University Hospitals, Leicester | N/A |
| Recruiting | The APS Phenotyping Study NCT06521502 | Vanderbilt University Medical Center | — |
| Recruiting | Impact of Immune Status on Secondary Infections in Patients With Acute Respiratory Failure NCT06511622 | Charite University, Berlin, Germany | — |
| Recruiting | Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe NCT06514209 | Southeast University, China | N/A |
| Recruiting | Comparison of Different Methods to Calculate Pendelluft by Electrical Impedance Tomography in Mechanically Ven NCT06494215 | University of Sao Paulo General Hospital | N/A |
| Active Not Recruiting | Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Re NCT06737432 | The University of Texas Medical Branch, Galveston | N/A |
| Recruiting | Effectiveness of Platform-Based Lateralization Therapy in Reducing Interface Pressure Between The Patient And NCT06819943 | University of Sao Paulo General Hospital | N/A |
| Not Yet Recruiting | Eit in ArdS for Tcav Setting (EAST Study) NCT06408272 | Central Hospital, Nancy, France | — |
| Recruiting | Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - NCT06593717 | Medical University of Vienna | N/A |
| Recruiting | Hemodynamic Monitoring and Fluid Responsiveness in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) NCT06593756 | Medical University of Vienna | N/A |
| Completed | A Combination of an Inhaled Budesonide and Ipratropium in Patients at Risk of Developing ARDS NCT06657079 | Damanhour University | Phase 1 / Phase 2 |
| Unknown | Role of Active Deresuscitation After Resuscitation: NCT06326112 | Unity Health Toronto | Phase 2 |
| Recruiting | Early Severe Illness TrAnslational BioLogy InformaticS in Humans NCT05591924 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Completed | Cardiopulmonary Bypass on Mechanical Power and Postoperative Pulmonary Complications NCT06292767 | TC Erciyes University | — |
| Unknown | IMV to Accelerate Recovery of Lung Function in Veno-venous Extracorporeal Membrane Oxygenation; Lung Rest Or M NCT06006676 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Recruiting | V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France) NCT05578742 | University Hospital, Angers | N/A |
| Unknown | Efficacy and Safety of Automated Closed-loop Ventilator vs Conventional Open-loop Ventilator in the Emergency NCT06157073 | University of Malaya | N/A |
| Recruiting | A Pilot Study of the Effect of the Combination of Inhaled Nitric Oxide and Prone Position Under EIT Monitoring NCT06741137 | Northern Jiangsu People's Hospital | N/A |
| Recruiting | PEEP Titration and Lung Recruitment Potential Assessed by 3D EIT NCT06594601 | Peking Union Medical College Hospital | — |
| Unknown | Effects of TCAV and Volume Control Ventilation on the Distribution of Aerated Lung Parenchyma in ARDS Patients NCT05874973 | Central Hospital, Nancy, France | N/A |
| Completed | Comparison of Guiding Sedation Level by Respiratory Effort Versus Usual Care in Mechanically Ventilated Patien NCT06242236 | Ramathibodi Hospital | N/A |
| Recruiting | NMR Based Metabolomics Kinetics in ARDS Patients NCT06036056 | Sanjay Gandhi Postgraduate Institute of Medical Sciences | — |
| Unknown | Safety and Efficacy of EXO-CD24 in Preventing Clinical Deterioration in Patients With Mild-Moderate ARDS NCT05947747 | Nano24med | Phase 2 |
| Recruiting | Longitudinal Recovery Trajectories After an Acute Respiratory Distress Syndrome, a New Understanding NCT06083363 | Institut de Recerca Biomèdica de Lleida | — |
| Recruiting | Ventilatory Parameters in Predicting Outcomes in ARDS Patients NCT06400095 | CentraCare | — |
| Completed | Correlation of SpO2/FIO2 Ratio With PaO2/FIO2 Ratio in ARDS Patients in the ICU of H. Adam Malik Hospital NCT06109168 | RS H Adam Malik | — |
| Completed | Generating Evidence in ECMO Ventilation Strategies NCT05708365 | Duke University | N/A |
| Unknown | V/Q Matching in Pressure Support Ventilation NCT05781802 | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | — |
| Recruiting | Xanthohumol as an Adjuvant in the Treatment of Septic Shock NCT06225258 | Medical University of Lublin | Phase 2 |
| Enrolling By Invitation | Impact of PEEP Trials on Ventilation-Perfusion Matching in ARDS Patients NCT06823804 | Ruijin Hospital | Phase 2 / Phase 3 |
| Completed | Pulmonary Diffusion of Antibiotics in Patients Admitted for ARDS Following SARS-CoV-2 Pneumonia NCT05464680 | Assistance Publique Hopitaux De Marseille | N/A |
| Terminated | Efficacy and Safety Evaluation of BZ371B in ARDS Patients NCT05384379 | Biozeus Biopharmaceutical S.A. | EARLY_Phase 1 |
| Unknown | Effects of Invasive Mechanical Ventilation on the Right Ventricular Function NCT05710419 | University of Giessen | — |
| Completed | Incremental and Decremental PEEP Titration by Diverse Strategies in Subjects with ARDS: a Prospective Physiolo NCT06808438 | West China Hospital | — |
| Completed | HRQOL of Life After ECMO Due to COVID-19. NCT05531032 | Medical University of Vienna | N/A |
| Recruiting | Improvement of Lung and Thoracic Compliance in ARDS Patients in Prone Position by Using Inflatable Air Bag NCT05515484 | Centre Hospitalier Universitaire, Amiens | Phase 2 |
| Unknown | Mechanical Ventilation in Patients With Lung Impairment Controlled by the Mechanical Energy of the Respiratory NCT06035146 | University Hospital Ostrava | N/A |
| Recruiting | Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS) NCT05354141 | Direct Biologics, LLC | Phase 3 |
| Unknown | A Reverification of the Berlin Definition Plateau Criteria in Golmud NCT05493839 | Southeast University, China | — |
| Unknown | Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induc NCT04377334 | University Hospital Tuebingen | Phase 2 |
| Unknown | Effect of Airway Pressure Release Ventilation on Right Ventricular Function Assessed by Transthoracic Echocard NCT05414110 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Unknown | Monitorings the Physiological Mechanism of Airway Pressure Release Ventilation in ARDS Patients by EIT NCT05406427 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | — |
| Unknown | Long-term Impact of COVID-19 Among COVID-19 Patients With Acute Respiratory Distress Syndrome in Brazil NCT05225194 | Hospital Moinhos de Vento | — |
| Completed | Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass NCT05647382 | Zhuan Zhang | N/A |
| Unknown | Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in NCT05101694 | Southeast University, China | — |
| Completed | Assessment of Analgesics and Sedatives in Mechanically Ventilated Patients With COVID-19 NCT05336656 | Wilkes University | — |
| Unknown | REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in pARDS NCT06067152 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | N/A |
| Unknown | Prone Positioning in COVID-19 Patients NCT05150847 | Tepecik Training and Research Hospital | N/A |
| Withdrawn | Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19 NCT05137795 | APR Applied Pharma Research s.a. | Phase 3 |
| Active Not Recruiting | Feasibility and Efficacy of Automated Lateral Decubitus Therapy in Hypoxemic Respiratory Failure NCT06698913 | University of Sao Paulo General Hospital | N/A |
| Completed | Mineralocorticoid Use in COVID-19 Patients NCT05453214 | Ain Shams University | Phase 3 |
| Unknown | Artificial Intelligence in Categorizing the Severity of Oxygenation by Incorporating the PEEP Into the Definit NCT05371314 | National University Health System, Singapore | — |
| Withdrawn | Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients NCT06093958 | HealthPartners Institute | N/A |
| Unknown | Incidence and Clinical Characteristics of Pulmonary Hypertension Secondary to ARDS in the Highland NCT05166759 | Southeast University, China | — |
| Active Not Recruiting | Speckle Tracking and Inhaled Nitric Oxide in Acute Respiratory Distress Syndrome NCT05104606 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Effect of Nava on Weaning Outcome in Patients With Mechanical Ventilation NCT05219643 | Southeast University, China | N/A |
| Withdrawn | A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and NCT04953052 | Exvastat Ltd. | Phase 2 |
| Unknown | Protective Effect of Sivelestat Sodium on ARDS in Patients With Sepsis NCT04973670 | Southeast University, China | Phase 3 |
| Unknown | Effectiveness of Recruitment Maneuvers and Lung Protective Ventilation Strategy in ARDS NCT05023226 | Asia University | N/A |
| Unknown | Effect of Early Treatment With Sivelestat Sodium in ARDS Patients NCT05020210 | Nanfang Hospital, Southern Medical University | — |
| Completed | The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID- NCT05035589 | Sciberras, Stephen M.D. | — |
| Unknown | Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome NCT05056090 | University Hospital, Grenoble | N/A |
| Withdrawn | Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells for Non-COVID-19 Acute Respiratory Distress Syndrom NCT04909879 | Sorrento Therapeutics, Inc. | Phase 2 |
| Completed | An Evaluation of End-Expiratory Lung Volume and Pulmonary Mechanics With Different PEEP Levels in Mechanical V NCT05993780 | Pamukkale University | N/A |
| Completed | Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS) NCT05092737 | University of Lausanne Hospitals | — |
| Unknown | Non-invasive Nervus Vagus Stimulation in Patients With COVID-19 and ARDS NCT05058742 | Vienna Hospital Association | N/A |
| Completed | Role of Pulmonary Perfusion on Tolerance to Supine Position in Patients With ARDS NCT05408442 | Pontificia Universidad Catolica de Chile | — |
| Completed | Driving Pressure Guided VT in ARDS Patients NCT05207267 | Southeast University, China | N/A |
| Unknown | The Effectiveness of Respiratory Tele-rehabilitation After COVID-19 Pneumonia Related: a Randomized Controlled NCT05007457 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Completed | Continuous Flow Ventilation With the Ventijet System in Acute Respiratory Distress Syndrome: a First-in-Human NCT07121257 | Hospital del Mar | N/A |
| Completed | Comparison of ARDS COVID-19 (WHO) vs ARDS Influenza in the ICU NCT04941092 | Central Hospital, Nancy, France | — |
| Unknown | Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO NCT04832789 | University of Toronto | N/A |
| Terminated | Inhaled Aviptadil for the Treatment of COVID-19 in Patients at High Risk for ARDS NCT04536350 | Prof. Dr. Jörg Leuppi | Phase 2 |
| Unknown | Long-Term Functional, Quality-of-Life, Neuropsychological and Cognitive Outcomes in COVID-19 Critical Illness NCT04881266 | University of Zurich | — |
| Unknown | PLAIAR-Trial: Platelets in Inflammation and Resolution NCT05098106 | University Hospital Muenster | — |
| Completed | Closed Loop Ventilation in Patients With COVID-19 NCT04873336 | Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital | — |
| Completed | Effects of Trunk Postural Change on CO2 Removal Efficiency in ARDS Patients: Quasi-experimental Study NCT05281536 | Clinica las Condes, Chile | N/A |
| Completed | Breethe Abiomed Recovery RegisTry (BART) NCT05473130 | Abiomed Inc. | — |
| Completed | FilmArray® and Management of Ventilator Associated Pneumonia in COVID-19 ARDS NCT05076240 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Duration of Prone Position in the Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19). NCT05012267 | Ignacio Saez de la Fuente | N/A |
| Terminated | Intravenous Imatinib in Mechanically Ventilated COVID-19 Patients NCT04794088 | Dr. Jurjan Aman | Phase 2 |
| Completed | PRONing to Facilitate Weaning From ECMO in Patients With Refractory Acute Respiratory Distress Syndrome NCT04607551 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Assessment of Lung Mechanics in COVID-19 Acute Respiratory Distress Syndrome NCT04597853 | University of Zurich | — |
| Unknown | Driving Pressure as a Predictor of Mortality in Acute Respiratory Distress Syndrome Patients NCT04778228 | Assiut University | — |
| Withdrawn | Study of Intravenous Administration of Allogeneic Adipose-Derived Mesenchymal Stem Cells for COVID-19-Induced NCT04728698 | Sorrento Therapeutics, Inc. | Phase 2 |
| Completed | Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study NCT04663802 | University of Pennsylvania | N/A |
| Terminated | Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19 NCT04360096 | APR Applied Pharma Research s.a. | Phase 2 / Phase 3 |
| Completed | Effect of Two Different Doses of Dexamethasone in Patients With ARDS and COVID-19 NCT04663555 | Brno University Hospital | Phase 4 |
| Completed | A Prospective Clinical Study to Explore Response to Prone Positioning in ARDS Patients NCT04692779 | Rush University Medical Center | — |
| Unknown | The Study of EIT-guided Ventilation Strategy on ARDS Patients NCT04734340 | Peking Union Medical College Hospital | N/A |
| Completed | Almitrine in COVID-19 Patients With ARDS Treated by HFNO NCT05216575 | Centre Hospitalier Universitaire de Nice | — |
| Completed | Umbilical Cord Lining Stem Cells (ULSC) in Patients With COVID-19 ARDS NCT04494386 | Restem, LLC. | Phase 1 / Phase 2 |
| Completed | Glenzocimab in SARS-Cov-2 Acute Respiratory DistrEss syNdrome Related to COVID-19 NCT04659109 | Acticor Biotech | Phase 2 |
| Completed | A First-in-Human Study of AV-001 in Healthy Subjects NCT04737486 | Vasomune Therapeutics, Inc. | Phase 1 |
| Completed | High Dose Vitamin-D Substitution in Patients With COVID-19: a Randomized Controlled, Multi Center Study NCT04525820 | Prof. Dr. Jörg Leuppi | N/A |
| Recruiting | Clinical Decision Support Tool in PARDS Pilot Study NCT04068012 | Children's Hospital Los Angeles | N/A |
| Unknown | Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography NCT04725227 | Shanghai Zhongshan Hospital | — |
| Suspended | A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC Vs. Pla NCT04401475 | Edesa Biotech Inc. | Phase 2 / Phase 3 |
| Recruiting | Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19) NCT03963622 | Unity Health Toronto | N/A |
| Terminated | Stellate Ganglion Blockade in Corona Virus 2019 (COVID-19) Positive Patients NCT04445337 | University of Nebraska | Phase 1 |
| Completed | FX06 to Rescue Acute Respiratory Distress Syndrome During Covid-19 Pneumonia NCT04618042 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome (ARDS) NCT04581811 | University of Alabama at Birmingham | N/A |
| Unknown | CORONA (COvid pRONe hypoxemiA): Prone Positioning for Hypoxemic COVID-19 Patients With Do-not-intubate Goals NCT04402879 | University of Calgary | N/A |
| Unknown | Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19 NCT05228717 | Olive View-UCLA Education & Research Institute | — |
| Completed | Treatment With Pirfenidone for COVID-19 Related Severe ARDS NCT04653831 | Soroka University Medical Center | N/A |
| Unknown | Effects of Sevoflurane on Extravascular Lung Water and Pulmonary Vascular Permeability in Patients With ARDS NCT04530188 | Bicetre Hospital | Phase 3 |
| Terminated | Open-label Multicenter Study to Evaluate the Efficacy of PLX-PAD for the Treatment of COVID-19 NCT04614025 | Pluristem Ltd. | Phase 2 |
| Unknown | Critical Care Results of SARS-CoV-2 ARDS by Dapsone and Standard COVID-19 Treatment NCT04918914 | Hunt Regional Medical Center | EARLY_Phase 1 |
| Terminated | Double-Blind, Multicenter, Study to Evaluate the Efficacy of PLX PAD for the Treatment of COVID-19 NCT04389450 | Pluristem Ltd. | Phase 2 |
| Completed | Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome NCT04667923 | I.M. Sechenov First Moscow State Medical University | — |
| Completed | REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia NCT04468971 | Cellenkos, Inc. | Phase 1 |
| Completed | Tenecteplase in Patients With COVID-19 NCT04505592 | Hooman Poor | Phase 2 |
| Completed | Extracellular Vesicle Infusion Treatment for COVID-19 Associated ARDS NCT04493242 | Direct Biologics, LLC | Phase 2 |
| Completed | Functional Recovery From Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19: Influence of Socio-Econom NCT04556513 | Centre Hospitalier Universitaire Dijon | — |
| Terminated | Losartan and Spironolactone Treatment for ICU Patients With COVID-19 Suffering From ARDS NCT04643691 | Assistance Publique Hopitaux De Marseille | Phase 2 |
| Completed | Safety and Efficacy of SCD in AKI or ARDS Patients Associated With COVID-19 Infections NCT04395911 | SeaStar Medical | N/A |
| Unknown | Right Ventricular Dysfunction in Ventilated Patients With COVID-19 NCT04764032 | University of Glasgow | — |
| Withdrawn | Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot Randomized Clinical Trial NCT04360876 | University of Colorado, Denver | Phase 2 |
| Unknown | Ventilatory Efficiency in Critically Ill COVID-19 Patients NCT04694742 | ASST Fatebenefratelli Sacco | — |
| Completed | Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19 NCT04570254 | Unidad Temporal COVID-19 en Centro Citibanamex | N/A |
| Unknown | Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Ge NCT04519398 | Grigore T. Popa University of Medicine and Pharmacy | — |
| Completed | Intensive Care Therapy of Covid-19 Disease in Germany NCT04455451 | University Hospital Tuebingen | — |
| Unknown | Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19 NCT04499313 | Chattogram General Hospital | Phase 3 |
| Completed | Postural Recruitment Maneuver in Patients With Acute Respiratory Distress Syndrome Due to COVID-19 Infection NCT04475068 | Hospital Nacional Edgardo Rebagliati Martins | — |
| Completed | Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury NCT04412057 | Aevi Genomic Medicine, LLC, a Cerecor company | Phase 2 |
| Completed | Prone Position for Nonintubated Patients With COVID-19 and Hypoxemic Respiratory Failure NCT04641182 | Pontificia Universidad Catolica de Chile | — |
| Completed | Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Pro NCT04553367 | King Abdul Aziz Specialist Hospital | Phase 1 / Phase 2 |
| Completed | Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Pro NCT06072248 | King Abdul Aziz Specialist Hospital | Phase 1 / Phase 2 |
| Completed | Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Pro NCT06072222 | King Abdul Aziz Specialist Hospital | Phase 1 / Phase 2 |
| Completed | Comparison of Volume Assist Control, Dual Mode and Airway Pressure Release Ventilation. NCT04196738 | University Hospital, Angers | N/A |
| Completed | PROne Positioning in coVID-19 Oxygeno-dependent Patients in Spontaneous Ventilation (PROVID Study) NCT04366856 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Follow-up of Critical COVID-19 Patients NCT04474249 | Uppsala University | — |
| Completed | Prediction of Acute Kidney Injury in Patients With COVID-19 NCT04406688 | University Hospital Muenster | — |
| Completed | Dornase Alfa for ARDS in Patients With Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) NCT04402970 | University of Missouri-Columbia | Phase 3 |
| Unknown | One-year Outcomes in Survivors of the Severe COVID-19 Pneumonia (CO-Qo-ICU) NCT04401111 | Centre Hospitalier Universitaire de Nice | — |
| Completed | Timing of Tracheotomy in Covid-19 Patients NCT04412356 | Sahlgrenska University Hospital | N/A |
| Completed | Lung Ultrasound in COVID-19 Patients NCT04487769 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Terminated | A Phase 2 Study to Evaluate Axatilimab for Hospitalized Participants With Respiratory Involvement Secondary to NCT04415073 | Syndax Pharmaceuticals | Phase 2 |
| Completed | A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19 NCT04402060 | Apellis Pharmaceuticals, Inc. | Phase 1 / Phase 2 |
| Completed | Use of Combined Prone Positioning and High-Flow Nasal Cannula, and Non-invasive Positive Pressure Ventilation NCT04694638 | Mayo Clinic | N/A |
| Completed | Plasma Adsorption in Patients With Confirmed COVID-19 NCT04358003 | Marker Therapeutics AG | N/A |
| Completed | Clinical Scores for Outcome Prediction in Patients With Severe COVID-19 Pneumonia Requiring ECMO NCT04405973 | Dr. Alexander Supady | — |
| Unknown | Prone Positioning for Patients on General Medical Wards With COVID19 NCT04383613 | Unity Health Toronto | N/A |
| Completed | COVid-19: Awake Proning and High-flow Nasal Cannula in respiratorY DistrEss NCT04395144 | Hôpital de Verdun | N/A |
| Unknown | Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 NCT04365101 | Celularity Incorporated | Phase 1 / Phase 2 |
| Unknown | Prone Positioning and High-flow Nasal Cannula in COVID-19 Induced ARDS NCT04391140 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Completed | Assessment of Lung Recruitablity of Acute Respiratory Distress Syndrome With SARS-CoV-2 Pneumonia by Electrica NCT04473300 | Osaka University | — |
| Completed | Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome NCT04351906 | University of Giessen | N/A |
| Completed | Awake Prone Positioning and Oxygen Therapy in Patients With COVID-19 NCT04407468 | Hospital General San Juan del Rio | — |
| Unknown | MultiStem Administration for COVID-19 Induced ARDS (MACoVIA) NCT04367077 | Healios K.K. | Phase 2 / Phase 3 |
| Unknown | Monitoring COVID-19 Patients' Lung Fluid Using Impedance Technique NCT04406493 | Hillel Yaffe Medical Center | N/A |
| Completed | Impact of Neck Inspiratory Muscle Activation During Sleep in ICU Patients After a COVID 19 ARDS NCT04371029 | University Hospital, Bordeaux | N/A |
| Completed | Use of UC-MSCs for COVID-19 Patients NCT04355728 | Camillo Ricordi | Phase 1 / Phase 2 |
| Completed | Thrombo Embolic Events in Critical Care Patients With Covid-19 Serious Acute Pneumopathy NCT04366752 | Centre Hospitalier Universitaire, Amiens | — |
| Completed | Respiratory and Hemodynamic Changes Induced in Mechanically Ventilated Patients for COVID-19 NCT04347928 | University Hospital, Lille | — |
| Completed | Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS NCT04386369 | Central Hospital, Nancy, France | — |
| Unknown | Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches NCT04410263 | University of Zurich | — |
| Completed | Pre-exposure Prophylaxis for SARS-Coronavirus-2 NCT04328467 | University of Minnesota | Phase 3 |
| Completed | Monitoring Anticoagulation in Patients on ECMO for Severe Lung Failure NCT06038682 | University Hospital Ostrava | — |
| Completed | Risk Factors and Computed Tomography Findings in COVID-19. NCT04577105 | Instituto Nacional de Cardiologia Ignacio Chavez | — |
| Completed | Investigational Treatments for COVID-19 in Tertiary Care Hospital of Pakistan NCT04492501 | UNICEF | N/A |
| Completed | PREdiction of DIagnosed Covid-19 infecTion in IUC Patients NCT04327180 | University Hospital, Lille | — |
| Completed | Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study NCT04365764 | Groupe Hospitalier Pitie-Salpetriere | — |
| Unknown | The RIsk Stratification in COVID-19 Patients in the ICU Registry NCT04357275 | University of Zurich | — |
| Completed | Ventilator-induced Lung Injury Vortex in Patients With SARS-CoV-2 NCT04174313 | Hospital El Cruce | — |
| Completed | Physical Activity Levels in COVID-19 Patients Admitted to Intensive Care NCT04396197 | University Hospital Birmingham NHS Foundation Trust | — |
| Completed | Ventilation Associated Pneumonia and Covid-19 NCT05089968 | Centre Hospitalier Universitaire de Nīmes | — |
| Completed | Cardiometry Versus Fluid and Catheter Treatment Trial (FACTT Lite) on Fluid Management in Acute Respiratory Di NCT04219150 | Tanta University | N/A |
| Completed | Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS. NCT05341687 | Central Hospital, Nancy, France | — |
| Completed | "Effects of Neuromuscular Blocking Agents on End Expiratory Lung Volume During Moderate-severe ARDS" NCT04996394 | University of Milano Bicocca | — |
| Unknown | Diagnostic Criteria of ARDS at High Altitudes in Western China NCT04215666 | Affiliated Hospital of Qinghai University | — |
| Terminated | Paediatric Ards Neuromuscular Blockade Study NCT02902055 | University Medical Center Groningen | Phase 4 |
| Unknown | Effects of End-expiratory Positive Pressure Optimization in Intubated Patients With Healthy Lung or Acute Resp NCT04503876 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Clinical and Physiological Assessment of a Nearly Ultra-protective Lung Ventilation Strategy: A Quasi-experime NCT04435613 | Clinica las Condes, Chile | N/A |
| Completed | Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impair NCT04067622 | University of Vermont | N/A |
| Completed | Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in NCT04035915 | Mahidol University | N/A |
| Unknown | The Effect of Caloric Supplement in the Clinical Outcomes in Acute Lung Injury Patients NCT04262440 | Taichung Veterans General Hospital | — |
| Unknown | Definition of ARDS in Qinghai Province: Verification of Berlin Definition Plateau Criteria NCT04199650 | Southeast University, China | — |
| Unknown | Breathing Pattern, WOB and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Sponta NCT04209270 | Sanatorio de la Trinidad Mitre | — |
| Completed | Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distre NCT03793842 | University of Michigan | N/A |
| Unknown | Prone Positioning and Spontaneous Breathing NCT03768154 | Osaka University | Phase 1 |
| Completed | Vitamin C Versus Nitric Oxide in Prolonged Ventilation NCT04411160 | King Abdul Aziz Specialist Hospital | — |
| Unknown | Effect of Inhalation Sedation Compared With Propofol on the Sepsis-related Acute Respiratory Distress Syndrome NCT04014218 | Moscow Regional Research and Clinical Institute (MONIKI) | Phase 4 |
| Completed | Cerebrovascular Hemodynamics in Patients With ARDS. NCT03949738 | Universitätsklinikum Hamburg-Eppendorf | — |
| Completed | Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO NCT03764319 | Medical University of Vienna | N/A |
| Unknown | Hospital-wide Incidence, Clinical Characteristics and Outcomes of ARDS NCT03546699 | University Health Network, Toronto | — |
| Unknown | Post- End- Expiratory Pressure Affect the Alveolar Heterogeneity in Moderate and Sever ARDS Patients NCT03763890 | Southeast University, China | — |
| Withdrawn | Effect of PEEP on Lung Recruitment and Homogeneity Over Time in Moderate to Severe ARDS NCT03140579 | Guy's and St Thomas' NHS Foundation Trust | — |
| Completed | Safety and Preliminary Efficacy of Sequential Multiple Ascending Doses of Solnatide to Treat Pulmonary Permeab NCT03567577 | Apeptico Forschung und Entwicklung GmbH | Phase 2 |
| Completed | Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients NCT03480555 | King Abdullah International Medical Research Center | N/A |
| Completed | Establishment of a Early Risk Model of ECMO in Children With ARDS NCT04710173 | Children's Hospital of Fudan University | — |
| Unknown | Effects of Different Driving Pressure on Lung Stress, Strain and Mechanical Power in Patients With Moderate to NCT03616704 | Jianfeng Xie | — |
| Unknown | The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung C NCT03341572 | Jingyuan,Xu | N/A |
| Terminated | Does Automated Closed-Loop Ventilation Reduce the DRiving Pressure Levels in Patients With ARDS NCT03211494 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Unknown | Heliox for Neonate With Acute Respiratory Distress Syndrome (ARDS) NCT03217149 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Unknown | Assisted or Controlled Ventilation in Ards (Ascovent) NCT03245684 | University of Roma La Sapienza | N/A |
| Completed | Blood Recirculation and vvECMO NCT03200314 | Charite University, Berlin, Germany | — |
| Unknown | Surfactant for Neonate With Acute Respiratory Distress Syndrome (ARDS) NCT03217162 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Completed | Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time NCT03076983 | Drägerwerk AG & Co. KGaA | — |
| Terminated | ARDS Esophageal Balloon Pressure Changes With Positioning Study NCT03120793 | University of North Carolina, Chapel Hill | — |
| Completed | A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS NCT03498807 | Hui-Ju Hsu | N/A |
| Unknown | Incidence of Dyssynchronies in Early ARDS NCT03447288 | Unity Health Toronto | — |
| Unknown | Change of Immune Cell of ARDS Patients：an Observational Study NCT02958748 | Southeast University, China | — |
| Completed | Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome NCT02871063 | Guillermo Ortiz Ruiz | — |
| Completed | Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Bar NCT02595060 | University of Giessen | Phase 2 |
| Unknown | An Observational Study of the Correlation Between miRNA in Peripheral Blood and Prognosis in Patients With ARD NCT02885675 | Southeast University, China | — |
| Completed | Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure NCT03225807 | Intermountain Health Care, Inc. | — |
| Completed | Nucleotide Polymorphism in ARDS Outcome NCT02644798 | Southeast University, China | — |
| Unknown | The Evaluation of NETs, Caspase-1 and Cytokines in ARDS Patients NCT03227107 | Xiangya Hospital of Central South University | — |
| Completed | Clinical Application of Electrical Impedance Tomography for Individual Adjustment of Ventilator Settings NCT02703012 | University Hospital Schleswig-Holstein | N/A |
| Completed | Extracorporeal Membrane Oxygenation in Coronavirus Disease (COVID-19), Influenza and ARDS of Other Ethiologies NCT05353725 | University Medical Centre Ljubljana | — |
| Completed | Assessment of Right Ventricular 2d-strain in Acute Respiratory Distress Syndrome NCT02638844 | Central Hospital, Nancy, France | — |
| Unknown | Acute Respiratory Distress Syndrome(ARDS) in Neonates NCT03227289 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Completed | MICU Recovery Clinic NCT02560129 | Wake Forest University Health Sciences | — |
| Unknown | Tomodensitometric Study of Pulmonary Effects of Intrapulmonary Percussive Ventilation in ARDS Patients NCT02510105 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Effects of Sedation on Transpulmonary Pressure and Lung Homogenous NCT03237806 | Southeast University, China | N/A |
| Completed | Changes in Cerebral Oxygenation During the Prone Position in Patients With Acute Respiratory Distress Syndrome NCT02415738 | Centre Hospitalier Bretagne Atlantique | — |
| Unknown | Positive End-expiratory Pressure and Esophageal Catheter Optimal Calibration Volume in ARDS Patients NCT02945917 | Magni Federico | — |
| Unknown | PEEP Levels Selected by PEEP Titration and PEEP Levels Routinely Used in Post-operative Cardiac Patients With NCT02056977 | University of Sao Paulo General Hospital | N/A |
| Completed | ED Lung Protective Ventilation to Reduce Complications NCT02543554 | Washington University School of Medicine | — |
| Completed | Relationship of Pulmonary Contusion to Pulmonary Inflammation and Incidence of Acute Respiratory Distress Synd NCT02265198 | Wake Forest University Health Sciences | — |
| Completed | Lung Imaging for Ventilatory Setting in ARDS NCT02149589 | University Hospital, Clermont-Ferrand | N/A |
| Terminated | Preventive Strategies in Acute Respiratory Distress Syndrome (ARDS) NCT02070666 | Corporacion Parc Tauli | N/A |
| Completed | ARDS Prediction Score in Critically Ill Patients in China NCT02174081 | Jianfeng Xie | — |
| Completed | The Educational ARDS Diagnosis Study NCT02054611 | University of Toronto | N/A |
| Unknown | Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on NCT02885584 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Optimization of PEEP for Alveolar Recruitment in ARDS NCT01949272 | Hopital of Melun | — |
| Completed | Drug Monitoring of Antibiotics in Critical Care Patients NCT01793012 | Ludwig-Maximilians - University of Munich | — |
| Unknown | PEEP Guided by Esophageal Balloon Measurement and Its Effect on Recruitment Maneuver NCT01737190 | Wolfson Medical Center | N/A |
| Unknown | Three Methods for Best PEEP Determination Compared With PEEP Determination Guided by Adult Respiratory Distres NCT01742715 | Wolfson Medical Center | N/A |
| Unknown | Adipose-derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome NCT01902082 | Shaoxing Second Hospital | Phase 1 |
| Unknown | Predictive Value of Troponin I for Acute Respiratory Distress Syndrome in Children With Shock NCT02361840 | Hospital Civil de Guadalajara | — |
| Unknown | Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance NCT01668368 | Wolfson Medical Center | N/A |
| Completed | Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome NCT01669863 | Hannover Medical School | Phase 1 / Phase 2 |
| Completed | Gas Exchange and CT Effects of PEEP in ARDS NCT04067154 | Policlinico Hospital | N/A |
| Unknown | Epidemiology and Prognosis of ARDS After Pulmonary Resection Surgery NCT04818554 | University Hospital, Montpellier | — |
| Unknown | Biomarker of Lung Injury in ARDS Patients Receiving ECMO Support NCT01967602 | National Taiwan University Hospital | — |
| Unknown | The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Underg NCT01825304 | Nanjing Medical University | Phase 4 |
| Completed | Mechanical Ventilation and Respiratory Muscle Work of Breathing in Acute Respiratory Distress Syndrome (ARDS) NCT01289600 | University Medical Center Nijmegen | N/A |
| Completed | Kinetics of Surfactant Proteins, Phosphatidylcholine and Body Water in Intensive Care Unit (ICU) NCT03371680 | University of Padova | N/A |
| Completed | Electrical Impedance Tomography (EIT) Monitoring in Adults With ALI or ARDS NCT01272882 | Christiana Care Health Services | N/A |
| Completed | Lung Sonography in Patients With Acute Respiratory Distress Syndrome in Intensive Care Unit NCT01881061 | University of Athens | — |
| Completed | ECMO for COVID-19 vs Influenza A H1N1 Associated ARDS NCT05080933 | University of Turin, Italy | — |
| Completed | Retrospective Postoperative ARDS Study at Vanderbilt University NCT00656071 | Vanderbilt University | — |
| Completed | Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit NCT00808691 | National Taiwan University Hospital | — |
| Completed | Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients NCT00299650 | Assistance Publique Hopitaux De Marseille | Phase 4 |
| Completed | Respiratory Mechanics and Pleural Effusion NCT00258518 | Policlinico Hospital | — |
| Completed | Effects of Variable Ventilation on Respiratory System of Acute Respiratory Distress Syndrome (ARDS) Patients NCT00202098 | Policlinico Hospital | N/A |
| Completed | The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients NCT00143468 | Policlinico Hospital | N/A |
| No Longer Available | Expanded Access for Use of bmMSC-Derived Extracellular Vesicles in Patients With COVID-19 Associated ARDS NCT04657458 | Direct Biologics, LLC | — |
| No Longer Available | Compassionate Use Open-Label Anti-CD14 Treatment in Patients With SARS-CoV-2 (COVID-19) NCT04346277 | Implicit Bioscience | — |