NCT02510105

Tomodensitometric Study of Pulmonary Effects of Intrapulmonary Percussive Ventilation in ARDS Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University Hospital, Clermont-Ferrand · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The study is intended to elucidate the pulmonary effects of Intrapulmonary Percussive Ventilation (IPV) with VDR4 ventilator of patients with ARDS, using computed tomography (CT).

Detailed description

Prospective clinical study in ICU of ventilated patients with ARDS. The morphologic pulmonary effects of IPV with VDR4 are not known to the investigators' knowledge. The main aim is to quantify recruited, normally aerated and overinflated parts of the lungs after a 1 hour treatment with IPV. Patients with ARDS (focal and non focal) consecutively admitted to the investigators' ICU are enrolled after informed consent. Patients are intubated and ventilated with Servo-I (GE) and ventilation is optimized according to ARDS-network recommandations. A first thoracic CT-scan is performed with ICU ventilator and then the patient is ventilated with VDR4 during 1 hour. A second thoracic CT-scan is then performed and the patient re-ventilated with ICU ventilator. Arterial blood gases and hemodynamic parameters are recorded during experiments. CT-scan are analysed and compared for normally aerated, overinflated and recruited lung parenchyma. Regions are determined thanks to their Hounsfield units (HU).

Conditions

• ARDS

Interventions

Type	Name	Description
DEVICE	VDR4 ventilator (Intrapulmonary Percussive Ventilation)
DEVICE	CT scan
DEVICE	Servo-i
DEVICE	- Intubation
DEVICE	Ventilation ( with an ICU conventional ventilator)

Timeline

• Start date: 2015-07-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2015-07-28
• Last updated: 2015-07-28

Locations

1 site across 1 country: France