| Not Yet Recruiting | INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla Heart Failure, Cardiogenic Shock, Reduced Ejection Fraction Heart Failure | N/A | 2026-04-01 |
| Recruiting | Impella Pump Return Study to Analyze Deposits and Biomaterial in Used Pumps Heart Failure | — | 2025-09-21 |
| Recruiting | Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic S AMI Cardiogenic Shock | — | 2025-07-10 |
| Active Not Recruiting | Abiomed Impella RT-DAQ - Observational Study Cardiogenic Shock | — | 2024-10-04 |
| Recruiting | Impella RP Flex with Smart Assist Right Ventricular (RV) Dysfunction | — | 2024-05-29 |
| Terminated | The RECOVER IV Trial ST-segment Elevation Myocardial Infarction (STEMI), Cardiogenic Shock | N/A | 2023-10-28 |
| Completed | V-A ECMO AUTO Mode Registry Heart Failure | — | 2023-10-11 |
| Active Not Recruiting | IMpella-Protected cArdiaC Surgery Trial (IMPACT) Left Ventricular Dysfunction | N/A | 2023-09-21 |
| Active Not Recruiting | IMPACT EU Post-Market Clinical Follow-Up Study Left Ventricular Dysfunction | N/A | 2023-04-27 |
| Enrolling By Invitation | Impella ECP Study (ECP Study) and Impella ECP Continued Access Protocol High-Risk Percutaneous Coronary Intervention | N/A | 2022-12-20 |
| Completed | Impella Real-World Surveillance of Patients Using Sodium Bicarbonate Cardiogenic Shock, High Risk PCI | — | 2022-12-15 |
| Active Not Recruiting | Use of the Impella BTR™ in Patients With Heart Failure: An Early Feasibility Study Heart Failure, Acute Decompensated Heart Failure | N/A | 2022-04-20 |
| Active Not Recruiting | Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Left Ventricular Dysfunction, Coronary Artery Disease | N/A | 2021-04-13 |
| Completed | Breethe Abiomed Recovery RegisTry (BART) Cardiopulmonary Bypass, ARDS, Heart Failure | — | 2021-03-31 |
| Active Not Recruiting | The Smart Pump Study Cardiac Output | N/A | 2020-11-02 |
| Active Not Recruiting | Impella ECP Early Feasibility Study High-risk Percutaneous Coronary Intervention | N/A | 2020-10-09 |
| Completed | SURPASS Impella 5.5 Study Cardiogenic Shock, Acute Decompensated Heart Failure | — | 2020-09-21 |
| Active Not Recruiting | Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial ST Elevation (STEMI) Myocardial Infarction of Anterior Wall | N/A | 2019-12-12 |
| Completed | Restore EF Observational Study Coronary Artery Disease, Unstable Angina, Angina, Stable | — | 2019-09-01 |
| Completed | SVC Occlusion in Subjects With Acute Decompensated Heart Failure Acute Decompensated Heart Failure, Acute Heart Failure, Congestive Heart Failure | N/A | 2019-07-31 |
| Unknown | The Global cVAD Study Cardiovascular Diseases | — | 2017-07-14 |
| Completed | Door To Unloading With IMPELLA CP System in Acute Myocardial Infarction - Safety and Feasibility Study STEMI | N/A | 2017-04-11 |
| Unknown | Protected PCI Study Heart Failure | — | 2015-11-01 |
| Unknown | The Use of Impella RP Support System in Patients With Right Heart Failure Right Heart Failure | N/A | 2013-05-01 |
| Unknown | Symphony: The Implantable Counter Pulsation Device (CPD) Safety and Feasibility Trial Chronic Heart Failure | Phase 1 / Phase 2 | 2011-11-01 |
| Terminated | MINI-AMI: Minimizing Infarct Size With Impella 2.5 Following PCI for Acute Myocardial Infarction ST-elevation Myocardial Infarction | N/A | 2011-04-01 |
| Terminated | Investigating the Role of Impella 2.5 System in Acutely Decompensated Chronic Heart Failure Patients Heart Failure | N/A | 2010-07-01 |
| Terminated | Trial Using Impella LP 2.5 System in Patients With Acute Myocardial Infarction Induced Hemodynamic Instability Acute Myocardial Infarction | Phase 3 | 2008-07-01 |
| Terminated | Voyager I: Patient Discharge Using the AB5000 Portable Driver System Acute Cardiac Dysfunction | Phase 3 | 2008-06-01 |
| Terminated | Protect II, A Prospective, Multicenter Randomized Controlled Trial Coronary Artery Disease | Phase 3 | 2007-10-01 |
| Completed | PROTECT I, A Prospective Feasibility Trial Investigating the Use of IMPELLA RECOVER LP 2.5 System in Patients Patients Undergoing High Risk PCI. | Phase 2 | 2006-08-01 |
| Completed | RECOVER I Impella RECOVER LP/LD 5.0 Support System Safety and Feasibility Study Cardiac Surgery | Phase 2 | 2006-08-01 |
| No Longer Available | AbioCor Implantable Replacement Heart Severe Biventricular End Stage Heart Disease | — | — |