NCT02902055

Paediatric Ards Neuromuscular Blockade Study

Life-threatening Acute Respiratory Failure in Children: to Breathe or Not to Breathe Spontaneously, That's the Question

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 3 (actual)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 0 Years – 5 Years
• Healthy volunteers: Not accepted

Summary

Paediatric acute respiratory distress syndrome (ARDS) is a manifestation of severe, life-threatening lung injury. Care for paediatric patient is mainly supportive and based on what works in adults and personal experiences, including the use of mechanical ventilation. However, differences in lung physiology and immunology between (young) children and adults suggests that adaptation of adult practices into paediatrics may not be justified. A study in adults with severe ARDS showed that early use of neuromuscular blocking agents (NMBA) improved 90-day survival and increased time off the ventilator without increasing muscle weakness. It is unknown if this is also true for paediatric ARDS

Conditions

• ARDS

Interventions

Type	Name	Description
DRUG	Neuromuscular Blocking Agents	Neuromuscular blockae
DRUG	Isotonic saline	Placebo

Timeline

• Start date: 2019-12-01
• Primary completion: 2024-05-01
• Completion: 2024-05-01
• First posted: 2016-09-15
• Last updated: 2025-02-07

Locations

1 site across 1 country: Netherlands