NCT03237806

Effects of Sedation on Transpulmonary Pressure and Lung Homogenous

Effects of Sedation on Transpulmonary Pressure and Lung Homogenous of ARDS Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The acute respiratory distress syndrome (ARDS) is characterized by severe respiratory failure. Open Lung and Lung Protective Strategy have been proved to improve mortality of ARDS patients. Preserving spontaneous breathing (SB) is good for inflating the lung lobe near diaphram during mechanical ventilation, however, strong respiratory drive could generate more transpulmonary pressure in ARDS patients, which increase the stress and strain in injured lung. Nonetheless, it's not clear if sedative has any effects on transpulmonary pressure of ARDS patients.The purpose of this study is to investigate the effects of sedation on transpulmonary pressure of ARDS patients.

Detailed description

Further study details as provided by Nanjing Zhong-da Hospital, School of Medicine, Southeast University

Conditions

• ARDS

Interventions

Type	Name	Description
DRUG	Deep sedated	Midazolam intravenous continusly infusion, Deep sedated (Ramsay 5)
DRUG	Light sedated	Midazolam intravenous continusly infusion, Light sedated (Ramsay 3)

Timeline

• Start date: 2015-05-31
• Primary completion: 2018-01-18
• Completion: 2018-03-18
• First posted: 2017-08-03
• Last updated: 2018-03-20

Locations

1 site across 1 country: China