NCT03227289

Acute Respiratory Distress Syndrome(ARDS) in Neonates

Pregnancy Risk Factors Promote Conversion From Neonatal Respiratory Distress Syndrome(NRDS) to Acute Respiratory Distress Syndrome(ARDS) : a Observational Cohort Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Academic / Other
• Sex: All
• Age: 5 Minutes – 28 Days
• Healthy volunteers: —

Summary

Acute respiratory distress syndrome in neonates has been defined in 2015. Earlier identification and successful intervention into the potential pregnancy associated risk factors for the conversion from NRDS to ARDS is one of the most important components of ARDS prevention.

Detailed description

Pregnancy risk factors (PRF), such as intrahepatic cholestasis during pregnancy(ICP), hypertensive disorder complicating pregnancy(HDCP) and gestational diabetes mellitus(GDM), are related to NRDS, ARDS and subsequent death. Meantime, it has also been proven that the prevention of PRF reduces the risk of NRDS and ARDS. However, few study reported the relations between PRF and the conversion from NRDS to ARDS, and it also remains unknown whether treating PRF can reduce the progression from NRDS to ARDS. We have found that PRF were related to the increase and deterioration of NRDS in a Chinese cohort. The aims of the present study were: 1). to report the effects of PRF on the conversion from NRDS to ARDS. 2). to clarify whether PRF treatment could prevention from conversion from NRDS to ARDS in a Chinese population.

Conditions

• ARDS
• NRDS

Interventions

Type	Name	Description
OTHER	Stayed in NRDS	The neonates with NRDS are stayed in NRDS.
OTHER	Converted to ARDS	The neonates with NRDS are converted to ARDS.

Timeline

• Start date: 2015-08-01
• Primary completion: 2023-12-30
• Completion: 2023-12-30
• First posted: 2017-07-24
• Last updated: 2022-10-25

Locations

1 site across 1 country: China