| Recruiting | Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) Acute Myeloid Leukemias | Phase 3 | 2025-11-25 |
| Recruiting | A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias Acute Myeloid Leukemias | Phase 1 | 2024-05-21 |
| Active Not Recruiting | MAXPIRe: Study to Evaluate Axatilimab in Participants With Idiopathic Pulmonary Fibrosis (IPF) Idiopathic Pulmonary Fibrosis | Phase 2 | 2023-12-11 |
| Completed | Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors Colorectal Cancer, Solid Tumors | Phase 1 / Phase 2 | 2023-04-04 |
| Completed | Study of Radiolabeled Revumenib in Adults With Acute Leukemia Acute Leukemia | Phase 1 | 2022-08-05 |
| Completed | A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia Relapsed/Refractory Leukemias, Acute Lymphoblastic Leukemia, Acute Lymphocytic Leukemia | Phase 1 | 2022-03-09 |
| Active Not Recruiting | A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD) Chronic Graft-versus-host-disease | Phase 2 | 2021-03-04 |
| Terminated | A Phase 2 Study to Evaluate Axatilimab for Hospitalized Participants With Respiratory Involvement Secondary to Coronavirus, COVID, ARDS | Phase 2 | 2020-05-30 |
| Recruiting | A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia | Phase 1 / Phase 2 | 2019-11-05 |
| Completed | A Phase 1/2 Study to Evaluate Axatilimab in Participants With Active cGVHD Chronic Graft-versus-host-disease | Phase 1 / Phase 2 | 2018-11-01 |
| Completed | A Phase 1 Study to Investigate Axatilimab Alone or in Combination With Durvalumab in Patients With Solid Tumor Solid Tumor, Metastatic Tumor, Locally Advanced Malignant Neoplasm | Phase 1 | 2017-09-01 |
| Completed | A Study to Evaluate the Pharmacokinetics of Entinostat in Adult Subjects With Normal and Impaired Renal Functi Renal Impairment, Healthy Volunteer | Phase 1 | 2017-07-27 |
| Completed | A Study to Examine the Effects of Entinostat on Midazolam in Healthy Adult Subjects Drug Interaction, Healthy Volunteer | Phase 1 | 2017-05-23 |
| Completed | Study of Avelumab With or Without Entinostat in Participants With Advanced Epithelial Ovarian Cancer Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer | Phase 1 / Phase 2 | 2016-12-19 |
| Completed | A Study to Examine the Effect of Omeprazole, Famotidine, and an Acidic Beverage on the Pharmacokinetics of Ent Volunteers, Healthy Volunteers, Human Volunteers | Phase 1 | 2016-10-25 |
| Completed | Study to Determine the Effect of the Timing of a Meal on the Pharmacokinetics of Entinostat Volunteers, Healthy Volunteers, Human Volunteers | Phase 1 | 2016-10-11 |
| Completed | Continuation Study of Entinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumors Neoplasms, Neoplasms, Glandular and Epithelial, Neoplasms by Histologic Type | Phase 1 | 2016-09-20 |
| Completed | Cardiac Safety Study of Entinostat in Men and Women With Advanced Solid Tumors Neoplasms, Neoplasms, Glandular and Epithelial, Neoplasms by Histologic Type | Phase 1 | 2016-08-24 |
| Completed | Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer Breast Cancer, Estrogen Receptor Positive Breast Cancer | Phase 1 | 2016-06-29 |
| Completed | Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead Breast Cancer | Phase 1 / Phase 2 | 2016-05-01 |
| Completed | Ph1b/2 Dose-Escalation Study of Entinostat With Pembrolizumab in Non-small Cell Lung Cancer (NSCLC) With Expan Non-Small Cell Lung Cancer, Melanoma, Mismatch Repair-Proficient Colorectal Cancer | Phase 1 / Phase 2 | 2015-08-26 |
| Withdrawn | Phase 2 Study of Fulvestrant With and Without Entinostat in Postmenopausal Women With ER+ Advanced Breast Canc Breast Cancer | Phase 2 | 2014-04-01 |
| Completed | Study to Assess Food Effect on Pharmacokinetics of Entinostat in Subjects With Breast Cancer or Non-Small Cell Lung Cancer, Non Small Cell Lung Cancer (NSCLC), Breast Cancer | Phase 1 | 2012-05-01 |
| Terminated | A Phase 2 Multi-Center Study of Entinostat (SNDX-275) in Patient With Relapsed or Refractory Hodgkin's Lymphom Hodgkin's Lymphoma | Phase 2 | 2009-04-13 |
| Completed | Study of the Effect of the Addition of SNDX-275 (Entinostat) to Continued Aromatase Inhibitor (AI) Therapy in ER+ Breast Cancer | Phase 2 | 2008-10-01 |
| Terminated | A Phase 2 Exploratory Study of Erlotinib and SNDX-275 in Participants With Non-small Cell Lung Carcinoma Who A Non Small Cell Lung Cancer | Phase 2 | 2008-08-01 |
| Completed | Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Breast Cancer, Estrogen Receptor-Positive Breast Cancer, Breast Cancer, Estrogen Receptor-Positive | Phase 2 | 2008-06-13 |
| Terminated | A Phase I, Multicenter, Open Label Study on the Effects of SNDX-275 on Expression of Biomarkers in Subjects Wi Breast Cancer | Phase 1 | 2008-06-01 |
| Completed | Study to Evaluate Erlotinib With or Without SNDX-275 (Entinostat) in the Treatment of Patients With Advanced N Non-Small-Cell Lung Carcinoma, Carcinoma, Non-Small Cell Lung | Phase 1 / Phase 2 | 2008-01-08 |
| No Longer Available | Expanded Access Program for Revumenib Relapsed/Refractory Acute Leukemia | — | — |